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Cancer: Cervical Cancer

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Total 449 results found since Jan 2013.

Cyclin ‐dependent kinase 9 promotes cervical cancer development via AKT2/p53 pathway
AbstractAberrant activation of cyclin ‐dependent kinase 9 (CDK9) is widespread in human cancers. However, the underlying mechanisms of CDK9 activation and the therapeutic potential of CDK9 inhibition in cervical cancer remain largely unknown. Here, we report that CDK9 is gradually upregulated during cervical lesion progression and reg ulated by HPV16 E6. CDK9 levels are highly correlated with FIGO stage, pathological grade, deep‐stromal invasion, tumor size, and lymph nodes metastasis. Knockdown of CDK9 by specific siRNA inhibits cervical cancer cell proliferation in vitro, as well as tumorigenesis in vivo. CDK9 inhibi...
Source: IUBMB Life - December 11, 2018 Category: Research Authors: Junfen Xu, Shanshan Xu, Yifeng Fang, Tingting Chen, Xing Xie, Weiguo Lu Tags: Research Communication Source Type: research

Glycoprotein nonmetastatic melanoma protein B accelerates tumorigenesis of cervical cancer in vitro by regulating the Wnt/ β-catenin pathway.
In conclusion, we demonstrated that GPNMB contributed to the tumorigenesis of cervical cancer, at least in part, by regulating MMP-2/MMP-9 activity in tumor cells via activation of canonical Wnt/β-catenin signaling. This might be a potential therapeutic target for treating human cervical cancer. PMID: 30484490 [PubMed - in process]
Source: Brazilian Journal of Medical and Biological Research - November 30, 2018 Category: Research Tags: Braz J Med Biol Res Source Type: research

Effects of forkhead Box protein A1 on cell proliferation regulating and EMT of cervical carcinoma.
CONCLUSIONS: FOXA1 expression increased in cervical cancer. Inhibition of FOXA1 expression blocked the proliferation of cervical cancer, promoted tumor cell apoptosis, suppressed the occurrence of EMT and VEGF production, and can regulate cervical cancer metastasis. FOXA1 can be used as a new molecular biological target for cervical cancer diagnosis and treatment. PMID: 30468461 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 24, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Role of DDX53 in taxol-resistance of cervix cancer cells in  vitro.
In this study, the role of DDX53 in taxol-resistance of cervix cancer cells was investigated. In taxol-resistant HelaTR cells, DDX53 was significantly increased as compared to the parental HeLa cells. HelaTR cells also showed upregulation of multidrug resistant gene MDR1, invasive characteristics and decreased apoptosis. In addition, increased autophagy level was observed in HelaTR cells. Overexpression of DDX53 in HeLa and SiHa markedly led to greater resistance to taxol and cisplatin, whereas knockdown of DDX53 in HelaTR cells restored sensitivity, demonstrating that DDX53 regulated taxol resistance in cervix cancer cell...
Source: Biochemical and Biophysical Research communications - November 22, 2018 Category: Biochemistry Authors: Park SY, Kim WJ, Byun JH, Lee JJ, Jeoung D, Park ST, Kim Y Tags: Biochem Biophys Res Commun Source Type: research

Lymphotoxin ‐β receptor‐NIK signaling induces alternative RELB/NF‐κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer
This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - November 22, 2018 Category: Molecular Biology Authors: Rita Das, Jamie Coupar, Paul E. Clavijo, Anthony Saleh, Tsu ‐Fan Cheng, Xinping Yang, Jianhong Chen, Carter VanWaes, Zhong Chen Tags: RESEARCH ARTICLE Source Type: research

NCK1 promotes the angiogenesis of cervical squamous carcinoma via Rac1/PAK1/MMP2 signal pathway.
CONCLUSIONS: Nck1 promotes the angiogenesis-inducing capacity of CSCC via the Rac1/PAK1/MMP2 signal pathway. PMID: 30442385 [PubMed - as supplied by publisher]
Source: Gynecologic Oncology - November 13, 2018 Category: Cancer & Oncology Authors: Xia P, Huang M, Zhang Y, Xiong X, Yan M, Xiong X, Yu W, Song E Tags: Gynecol Oncol Source Type: research

Effect of hypoxia on the Twist1 in EMT of cervical cancer cells.
CONCLUSIONS: Hypoxia may account for the increased invasion of HeLa cells, which is realized by the up-regulated GLI-1. PMID: 30402835 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 9, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

CXCL12 modulates the radiosensitivity of cervical cancer by regulating CD44.
In conclusion, the present data demonstrated that CXCL12 served an important role in the radioresistance of cervical cancer, suggestinh a novel therapeutic target. PMID: 30320394 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - October 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Long Non-Coding RNA ZEB1-Antisense 1 Affects Cell Migration and Invasion of Cervical Cancer by Regulating Epithelial-Mesenchymal Transition via the p38MAPK Signaling Pathway
Conclusion: Inhibition of ZEB1-AS1 can block the p38MAPK signaling pathway, ultimately restricting the EMT and suppressing cell migration and invasion of cervical cancer cells.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - October 5, 2018 Category: OBGYN Source Type: research

Cancers, Vol. 10, Pages 347: NACC1, as a Target of MicroRNA-331-3p, Regulates Cell Proliferation in Urothelial Carcinoma Cells
Fujimoto Chiho Ohbayashi The nucleus accumbens-associated protein 1 (NACC1) is a transcription factor constitutively expressed in the urothelium, where it regulates cell growth, senescence, autophagy, and epithelial-mesenchymal transition. microRNA (miRNA) constitutes a class of small non-coding RNAs which are involved in cell proliferation, differentiation, and progression of tumors. miRNAs and their target molecules are utilized for molecular diagnosis of urothelial carcinoma. NACC1 is one of several putative target molecules of miR-331-3p, and is associated with cell proliferation in cancers such as prostate and ...
Source: Cancers - September 21, 2018 Category: Cancer & Oncology Authors: Kohei Morita Tomomi Fujii Hiroe Itami Tomoko Uchiyama Tokiko Nakai Kinta Hatakeyama Aya Sugimoto Makito Miyake Yasushi Nakai Nobumichi Tanaka Keiji Shimada Masaharu Yamazaki Kiyohide Fujimoto Chiho Ohbayashi Tags: Article Source Type: research

Down-regulation of long non-coding RNA ANRIL inhibits the proliferation, migration and invasion of cervical cancer cells.
CONCLUSION: The key findings of our study demonstrated that the inhibition of lncRNA ANRIL reduces the proliferation, migration and invasion capabilities of CC cells. Down-regulation of ANRIL may serve as a potential therapeutic target in the treatment of CC. PMID: 30198868 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - September 12, 2018 Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research

Inhibiting 6-phosphogluconate dehydrogenase enhances chemotherapy efficacy in cervical cancer via AMPK-independent inhibition of RhoA and Rac1
ConclusionsOur work is the first to demonstrate the aberrant expression of 6PGD and its predominant roles in cervical cancer cell growth and migration, via a AMPK-dependent activation. Our findings suggest 6PGD as a potential therapeutic target to enhance chemosensitivity in cervical cancer.
Source: Clinical and Translational Oncology - September 4, 2018 Category: Cancer & Oncology Source Type: research

Acid degradable cationic galactose-based hyperbranched polymers as nano-therapeutic vehicles for Epidermal Growth Factor Receptor (EGFR) knockdown in Cervical Carcinoma.
In this study we synthetized by reversible addition-fragmentation chain transfer (RAFT) polymerization, several acid degradable galactose-based hyperbranched cationic polymers with varying molecular weights (10 to 20 kDa) and compositions with 2-lactobioamidoethyl methacrylamide [LAEMA] and 2- aminoethyl methacrylamide hydrochloride [AEMA] at different ratios (2.0, 1.0 & 0.5) and evaluated their ability to enhance Epidermal Growth Factor Receptor (EGFR) knockdown in cervical carcinoma. All the polymer constructs have enhanced capabilities to condensate siRNA (short interfering RNA), showing low toxicity at higher LAEMA...
Source: Biomacromolecules - August 29, 2018 Category: Biochemistry Authors: Peng YY, Diaz-Dussan D, Kumar P, Narain R Tags: Biomacromolecules Source Type: research

SiRNA interfering STAT3 enhances DDP sensitivity in cervical cancer cells.
CONCLUSIONS: STAT3 over-expression is associated with DDP resistance in cervical cancer. Decreasing STAT3 can significantly promote the apoptosis of cervical cancer CaSki cells and decrease the DDP resistance. PMID: 30024597 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 20, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research