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Cancer: Cervical Cancer
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Total 449 results found since Jan 2013.
Rewiring of lactate-IL-1 β auto-regulatory loop with Clock-Bmal1: A feed-forward circuit in glioma
Mol Cell Biol. 2021 Jun 14:MCB0044920. doi: 10.1128/MCB.00449-20. Online ahead of print.ABSTRACTDe-synchronized circadian rhythm in tumors is coincident with aberrant inflammation and dysregulated metabolism. As their inter-relationship in cancer etiology is largely unknown, we investigated the link between the three in glioma. Tumor metabolite lactate- mediated increase in pro-inflammatory cytokine IL-1β was concomitant with elevated levels of core circadian regulators Clock and Bmal1. siRNA mediated knockdown of Bmal1 and Clock decreased (i) LDHA and IL-1β levels and (ii) release of lactate and pro-inflammatory cytokin...
Source: Mol Biol Cell - June 14, 2021 Category: Molecular Biology Authors: Pruthvi Gowda Kirti Lathoria Shalini Sharma Shruti Patrick Sonia B Umdor Ellora Sen Source Type: research
lncRNA WT1-AS is upregulated in osteoporosis and regulates the apoptosis of osteoblasts by interacting with p53
Exp Ther Med. 2021 Jul;22(1):734. doi: 10.3892/etm.2021.10166. Epub 2021 May 9.ABSTRACTIn cervical cancer, cellular tumor antigen p53 (p53) interacts with long non-coding WT1 antisense RNA (WT1-AS) and this protein serves an important role in osteoporosis. The present study aimed to investigate the role of WT1-AS in osteoporosis. WT1-AS was upregulated in the plasma of patients with osteoporosis and was positively correlated with p53 expression. Altered expression of WT1-AS and p53 separated patients with osteoporosis from healthy controls. Expression levels of WT1-AS and p53 decreased with prolonged treatment. In osteobla...
Source: Experimental and Therapeutic Medicine - May 31, 2021 Category: General Medicine Authors: Chaoqun Wang Quan Xie Wen Sun Ying Zhou Yu Liu Source Type: research
LncRNA RUSC1-AS1 promotes osteosarcoma progression through regulating the miR-340-5p and PI3K/AKT pathway
In conclusion, our study demonstrated that RUSC1-AS1 promoted osteosarcoma development both in vitro and in vivo through sponging to miR-340-5p and activating the PI3K/AKT signaling pathway. Therefore, RUSC1-AS1 becomes a potential therapeutic target for osteosarcoma.PMID:34048366 | DOI:10.18632/aging.203047
Source: Aging - May 28, 2021 Category: Biomedical Science Authors: Chang-Jun Tong Qing-Chun Deng Di-Jun Ou Xia Long He Liu Kang Huang Source Type: research
Novel small molecule inhibitor of Kpn β1 induces cell cycle arrest and apoptosis in cancer cells
This study investigated the effect of a novel small molecule, Inhibitor of Nuclear Import-60 (INI-60), on cancer cell biology, as well as nuclear import activities associated with Kpnβ1, and cancer progression in vivo using cervical and oesophageal cancer cell lines. INI-60 treatment resulted in the inhibition of cancer cell proliferation, colony formation, migration and invasion, and induced a G1/S cell cycle arrest, followed by cancer cell death via apoptosis. Non-cancer cells were minimally affected by INI-60 at concentrations that inhibited cancer cells. INI-60 treatment altered the localisation of Kpnβ1 and its carg...
Source: Experimental Cell Research - May 21, 2021 Category: Cytology Authors: Aderonke Ajayi-Smith Pauline van der Watt Nonkululeko Mkwanazi Sarah Carden John O Trent Virna D Leaner Source Type: research
Nucleolin Promotes Cisplatin Resistance in Cervical Cancer by the YB1-MDR1 Pathway
CONCLUSION: Our findings revealed the novel role of NCL in cisplatin-resistant cervical cancer and NCL may be a potential therapeutic target for chemoresistance.PMID:33976698 | PMC:PMC8084676 | DOI:10.1155/2021/9992218
Source: Journal of Oncology - May 12, 2021 Category: Cancer & Oncology Authors: Jing Ke Chunming Gu Heyan Zhang Yang Liu Wenhao Zhang Huiling Rao Shan Li Fuyun Wu Source Type: research
GSE173120 RNA sequencing (RNA-SEQ) of ER- α36 knockdown by siRNA in cervical cancer cells
In conclusion, high expression of ER-α36 was correlated with a poor prognosis and metastasis in cervical cancer by regulating HMGA2.ER-α36 might serve as a prognostic biomarker and a target for cervical cancer treatment.
Source: GEO: Gene Expression Omnibus - April 23, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Knockdown of p62/sequestosome enhances ginsenoside Rh2-induced apoptosis in cervical cancer HeLa cells with no effect on autophagy
Biosci Biotechnol Biochem. 2021 Feb 5:zbab019. doi: 10.1093/bbb/zbab019. Online ahead of print.ABSTRACTp62/sequestosome is a multifunctional adaptor protein that participates in a wide variety of cellular processes. 20(S)-Ginsenoside Rh2 (G-Rh2) has various biological effects, including anticancer activity. We found that G-Rh2 can induce apoptosis and autophagy in HeLa cells. G-Rh2 significantly enhanced the transcriptional level of p62. A siRNA was constructed to knock down p62 and assess its effect on apoptosis induced by G-Rh2. p62 protein levels were successfully downregulated in cells transfected with the p62-specific...
Source: Bioscience, Biotechnology, and Biochemistry - March 30, 2021 Category: Biochemistry Authors: Shuai Bian Yue Zhao Fangyu Li Shuyan Lu Song Yang Meichen Liu Siming Wang Daqing Zhao Wei Zhang Jiawen Wang Source Type: research
Silencing of circular RNA_0000326 inhibits cervical cancer cell proliferation, migration and invasion by boosting microRNA-338-3p-dependent down-regulation of CDK4
Aging (Albany NY). 2021 Mar 17;13. doi: 10.18632/aging.103711. Online ahead of print.ABSTRACTCervical cancer is one of the leading causes of cancer-related death among women, which is attributed partly by limited treatment options. Recent studies have provided in-depth explanations regarding the role of circular RNA in cancers. We aimed to investigate the role of circular RNA_0000326 in cervical cancer. Bioinformatics analysis revealed a high circ_0000326 expression in cervical cancer. Cervical cancer cells and tissues were also observed to have elevated levels of circ_0000326 and the upregulation of circ_0000326 depended ...
Source: Aging - March 18, 2021 Category: Biomedical Science Authors: Zhaoxin Wang Chenchen Ren Li Yang Xiaoan Zhang Jiaxi Liu Yuanhang Zhu Dongyuan Jiang Source Type: research
