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Total 449 results found since Jan 2013.

Ultrathin SU-8 membrane for highly efficient tunable cell patterning and massively parallel large biomolecular delivery
This study presents a novel and efficient technique that enables massively parallel high throughput cell patterning and precise delivery of small to large biomolecules into patterned cells. The innovative cell patterning device proposed in this study is a standalone, ultrathin 3D SU-8 micro-stencil membrane, with a thickness of 10 μm. It features an array of micro-holes ranging from 40 μm to 80 μm, spaced apart by 50 μm to 150 μm. By culturing cells on top of this SU-8 membrane, the technique achieves highly efficient cell patterns varying from single-cell to cell clusters on a Petri dish. Utilizing this technique, we...
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Pallavi Shinde Ashwini Shinde Srabani Kar Kavitha Illath Moeto Nagai Fan-Gang Tseng Tuhin Subhra Santra Source Type: research

SCCA1/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production
Patients with cancer who have high serum levels of squamous cell carcinoma antigen 1 (SCCA1, now referred to as SERPINB3) commonly experience treatment resistance and have a poor prognosis. Despite being a clinical biomarker, the modulation of SERPINB3 in tumor immunity is poorly understood. We found positive correlations of SERPINB3 with CXCL1, CXCL8 (CXCL8/9), S100A8, and S100A9 (S100A8/A9) myeloid cell infiltration through RNA-Seq analysis of human primary cervical tumors. Induction of SERPINB3 resulted in increased CXCL1/8 and S100A8/A9 expression, which promoted monocyte and myeloid-derived suppressor cell (MDSC) migr...
Source: Journal of Clinical Investigation - August 1, 2023 Category: Biomedical Science Authors: Liyun Chen, Victoria Shi, Songyan Wang, Lulu Sun, Rebecca Freeman, Jasmine Yang, Matthew J. Inkman, Subhajit Ghosh, Fiona Ruiz, Kay Jayachandran, Yi Huang, Jingqin Luo, Jin Zhang, Pippa Cosper, Clifford J. Luke, Catherine S. Spina, Perry W. Grigsby, Julie Source Type: research

Cancers, Vol. 15, Pages 3810: Characterization of DoTc2 4510 & mdash;Identifying HPV16 Presence in a Cervical Carcinoma Cell Line Previously Considered to Be HPV-Negative
Cancers, Vol. 15, Pages 3810: Characterization of DoTc2 4510—Identifying HPV16 Presence in a Cervical Carcinoma Cell Line Previously Considered to Be HPV-Negative Cancers doi: 10.3390/cancers15153810 Authors: Nika Vučković Karin Hoppe-Seyler Angelika B. Riemer Cervical cancer is the fourth leading cause of cancer deaths in women, with over 340,000 women dying from this disease in 2020. Almost all cases have an underlying persistent infection with an oncogenic high-risk type of human papillomavirus (HPV), mainly HPV16. While cervical squamous cell carcinoma is hardly ever HPV-negative, a small subset...
Source: Cancers - July 27, 2023 Category: Cancer & Oncology Authors: Nika Vu čković Karin Hoppe-Seyler Angelika B. Riemer Tags: Article Source Type: research

Anti-HPV16 oncoproteins siRNA therapy for cervical cancer using a novel transdermal peptide PKU12
In conclusion, the transdermal peptide PKU12 is potentially a good candidate for a siRNA delivery vehicle for the treatment of cervical cancer.PMID:37350944 | PMC:PMC10282752 | DOI:10.3389/fonc.2023.1175958
Source: Cancer Control - June 23, 2023 Category: Cancer & Oncology Authors: Yan Deng Yi Song Quan Du Chi Chiu Wang Hu Li Yi Sui Yuying Zhang Tao Tang Source Type: research

Suppression of human papillomavirus type 16 E5 oncoprotein: A promising step in fostering the treatment of cervical cancer
In this study, we used E5-siRNA to knockdown that essential oncogene and considered the effect of E5 silencing on proliferation, apoptosis, cell cycle, apoptosis-related gene expression, and the initiator of the EGFR signaling pathway in cervical cancer cells. The results demonstrate that E5 plays an essential role in the proliferation and inhibited apoptosis in cervical cancer. Furthermore, silencing E5 reduces proliferation, increases apoptosis, and elevates related-genes expression of these malignant cells. Overall, E5 suppression may be appropriate for ameliorating cervical cancer progression.PMID:37305401 | PMC:PMC102...
Source: Oncology Research - June 12, 2023 Category: Cancer & Oncology Authors: Nima Hemmat Mohammad Amin Doustvandi Zahra Asadzadeh Ahad Mokhtarzadeh Behzad Baradaran Hossein Bannazadeh Baghi Source Type: research

WIF1 was downregulated in cervical cancer due to promoter methylation
In conclusion, the methylation of the WIF1 promoter leads to the downregulation of WIF1 and the activation of Wnt/β-catenin signaling in cervical cancer cells. WIF1 is a tumor suppressor that is inactivated in cervical cancer.PMID:37306343 | DOI:10.18388/abp.2020_6700
Source: Acta Biochim Pol - June 12, 2023 Category: Biochemistry Authors: Ying Wang Shifa Yuan Jing Ma Hong Liu Lizhen Huang Fengzhen Zhang Xiaomei Wang Source Type: research

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