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Cancer: Head and Neck Cancer
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Total 145 results found since Jan 2013.
Targeting STAT3 prevents bile reflux-induced oncogenic molecular events linked to hypopharyngeal carcinogenesis
J Cell Mol Med. 2021 Dec 1. doi: 10.1111/jcmm.17011. Online ahead of print.ABSTRACTThe signal transducer and activator of transcription 3 (STAT3) oncogene is a transcription factor with a central role in head and neck cancer. Hypopharyngeal cells (HCs) exposed to acidic bile present aberrant activation of STAT3, possibly contributing to its oncogenic effect. We hypothesized that STAT3 contributes substantially to the bile reflux-induced molecular oncogenic profile, which can be suppressed by STAT3 silencing or pharmacological inhibition. To explore our hypothesis, we targeted the STAT3 pathway, by knocking down STAT3 (STAT...
Source: Molecular Medicine - December 1, 2021 Category: Molecular Biology Authors: Dimitra P Vageli Panagiotis G Doukas Athanasios Siametis Benjamin L Judson Source Type: research
Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma
In this study, we performed a comprehensive transcriptome-based computational analysis on hundreds of HNSCC patients from TCGA and GEO databases, and found that DCLK1 expression positively correlates with NOTCH signaling pathway activation. Since NOTCH signaling has a recognized role in HNSCC tumorigenesis, we next performed a series of in vitro experiments in a collection of HNSCC cell lines to investigate the role of DCLK1 in NOTCH pathway regulation. Our analyses revealed that DCLK1 inhibition, using either a pharmacological inhibitor or siRNA, resulted in substantially decreased proliferation, invasion, migration, and ...
Source: Frontiers in Oncology - July 16, 2021 Category: Cancer & Oncology Source Type: research
GSE173161 Comparative analysis of gene expression after Oct4 or Scrambled siRNA knockdown in HNSCC cell lines
Contributors : Anna Dubrovska ; Linda Hein ; Vasyl LukiyanchukSeries Type : Expression profiling by arrayOrganism : Homo sapiensBy employing a global gene expression profiling, we performed analysis of the molecular pathways which are deregulated in head-and-neck cancer cell lines FaDu, Cal33 and UTSCC5 after siRNA mediated knockdown of Oct4 comparing to Scrambled.
Source: GEO: Gene Expression Omnibus - July 1, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Cancers, Vol. 13, Pages 2250: IGF2 Mediates Resistance to Isoform-Selective-Inhibitors of the PI3K in HPV Positive Head and Neck Cancer
Barak Rotblat
Moshe Elkabets
Over 50% of human papilloma positive head-and-neck cancer (HNCHPV+) patients harbor genomic-alterations in PIK3CA, leading to hyperactivation of the phosphatidylinositol-4, 5-bisphosphate 3-kinase (PI3K) pathway. Nevertheless, despite PI3K pathway activation in HNCHPV+ tumors, the anti-tumor activities of PI3K pathway inhibitors are moderate, mostly due to the emergence of resistance. Thus, for potent and long-term tumor management, drugs blocking resistance mechanisms should be combined with PI3K inhibitors. Here, we delineate the molecular mechanisms of the acquisition of resistance to...
Source: Cancers - May 7, 2021 Category: Cancer & Oncology Authors: Mai Badarni Manu Prasad Artemiy Golden Baisali Bhattacharya Liron Levin Ksenia M. Yegodayev Orr Dimitstein Ben-Zion Joshua Limor Cohen Ekaterina Khrameeva Dexin Kong Angel Porgador Alex Braiman Jennifer R. Grandis Barak Rotblat Moshe Elkabets Tags: Article Source Type: research
Differential expression of < em > COL4A3 < /em > and collagen in upward and downward progressing types of nasopharyngeal carcinoma
In conclusion, the gene mutation patterns were significantly different between the upward and downward progressing types of NPC. In addition, the expression level of the COL4A3 gene was decreased in the downward progressing type, which might promote NPC metastasis through the downregulation of extracellular collagen expression.PMID:33613712 | PMC:PMC7859474 | DOI:10.3892/ol.2021.12484
Source: Oncology Letters - February 22, 2021 Category: Cancer & Oncology Authors: Xiting Yang Qiuji Wu Fengyang Wu Yahua Zhong Source Type: research
Cigarette smoking promotes keratinocyte malignancy via generation of cancer stem-like cells
Conclusion: Our data suggest that smoking cigarettes promoted cancer stem-like cell generation in the head and neck area via the OCT-4/ID1/NF-κB/BMI-1 signaling pathway.
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Shuchun Lin, Wenfeng Mei, Haichun Lai, Xiufeng Li, Huanjiao Weng, Jiani Xiong, Xiuyun Lin, Tao Zeng, Qiong Zhang, Xing Liu, Yunlu Xu, Shubin Fang, Rong Jin, Xiaohua Hu, Jieming Xie, Jianbo Yang, Yiqing Zheng, Yuanzhong Chen, Jizhen Lin Tags: Research Paper Source Type: research
Evaluation of 18 FF-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy
Conclusions[18F]F-DPA can detect changes in TSPO expression levels after RT in HNSCC, which does not seem to reflect inflammation. Further studies are however needed to clarify the physiological mechanisms regulated by TSPO after RT.
Source: European Journal of Nuclear Medicine and Molecular Imaging - December 19, 2020 Category: Nuclear Medicine Source Type: research
Cancers, Vol. 12, Pages 2963: CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer
Kim
Gareth J. Thomas
Head and neck squamous cell carcinoma (HNSCC) is a heterogenous disease treated with surgery and/or (chemo) radiotherapy, but up to 50% of patients with late-stage disease develop locoregional recurrence. Determining the mechanisms underpinning treatment resistance could identify new therapeutic targets and aid treatment selection. C-terminal tensin-like (CTEN) is a member of the tensin family, upregulated in several cancers, although its expression and function in HNSCC are unknown. We found that CTEN is commonly upregulated in HNSCC, particularly HPV&minus;ve tumours. In vitro CTEN was...
Source: Cancers - October 13, 2020 Category: Cancer & Oncology Authors: Jason C. Fleming Jeongmin Woo Karwan Moutasim Christopher J. Hanley Steven J. Frampton Oliver Wood Matthew Ward Christopher H Woelk Christian H. Ottensmeier Sassan Hafizi Dae Kim Gareth J. Thomas Tags: Article Source Type: research
Role of Tropomyosin-related kinase B receptor and brain-derived neurotrophic factor in cancer.
Abstract
The tropomyosin-related kinase B (TrkB) receptor is a member of the neurotrophic tyrosine kinase receptors family and, together with the brain-derived neurotrophic factor (BDNF), plays an important role in the development of breast cancer, lung cancer, neuroblastoma, colorectal cancer, leukemia, cervical cancer, gallbladder cancer, gastric cancer, kidney cancer, Ewing's sarcoma, esophageal cancer, and head and neck cancer. Overexpression of these two factors has been associated with increased processes involved in carcinogenesis, such as invasion, migration, epithelial-mesenchymal transition (EMT), angiog...
Source: Cytokine - September 6, 2020 Category: Molecular Biology Authors: Serafim Junior V, Fernandes GMM, Oliveira-Cucolo JG, Pavarino EC, Goloni-Bertollo EM Tags: Cytokine Source Type: research
Arsenic trioxide disturbs the LIS1/NDEL1/dynein microtubule dynamic complex by disrupting the CLIP170 zinc finger in head and neck cancer.
Abstract
Cancer mortality is mainly caused by metastasis, which requires dynamic remodeling of cytoskeletal components such as microtubules. Targeting microtubules presents a promising antimetastatic strategy that could prevent cancer spreading and recurrence. It is known that arsenic trioxide (ATO) is able to inhibit the migration and invasion of solid malignant tumors, but its exact molecular mechanism remains unclear. Here, we report a novel molecular target and antimetastatic mechanism of ATO in head and neck squamous cell carcinoma (HNSCC). We found that cytoplasmic linker protein 170 (CLIP170) was overexpres...
Source: Toxicology and Applied Pharmacology - July 23, 2020 Category: Toxicology Authors: Gao L, Xue B, Xiang B, Liu KJ Tags: Toxicol Appl Pharmacol Source Type: research
Cancers, Vol. 12, Pages 908: Karyopherin- β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines
Cancers, Vol. 12, Pages 908: Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines
Cancers doi: 10.3390/cancers12040908
Authors:
Masaharu Hazawa
Hironori Yoshino
Yuta Nakagawa
Reina Shimizume
Keisuke Nitta
Yoshiaki Sato
Mariko Sato
Richard W. Wong
Ikuo Kashiwakura
Nuclear transport receptors, such as karyopherin-&beta;1 (KPNB1), play important roles in the nuclear-cytoplasmic transport of macromolecules. Recent evidence indicates the involvement of nuclear transport receptors in the pro...
Source: Cancers - April 7, 2020 Category: Cancer & Oncology Authors: Masaharu Hazawa Hironori Yoshino Yuta Nakagawa Reina Shimizume Keisuke Nitta Yoshiaki Sato Mariko Sato Richard W. Wong Ikuo Kashiwakura Tags: Article Source Type: research
Overexpression of Sal-like protein 4 in head and neck cancer: epigenetic effects and clinical correlations
ConclusionsOur findings indicate thatSALL4 upregulation correlates with HNSCC tumour aggressiveness and an adverse patient outcome. Our findings also indicate that DNMT3A may synergistically contribute to the regulatory effects of SALL4. Our findings provide insight into SALL4-mediated HNSCC development via epigenetic modulation.
Source: Cellular Oncology - April 1, 2020 Category: Cancer & Oncology Source Type: research
Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints.
Conclusions: Niraparib effectively radiosensitizes HNSCCs with a greater benefit seen in HPV(-). HPV status also plays a role in response to MK-8776 or MK-1775 when combined with niraparib due to differences in DNA repair mechanisms. This study suggests that using cell cycle abrogators in combination with PARP inhibitors may be a beneficial treatment option in HNSCC, but also emphasizes the importance of HPV status when considering effective treatment strategies.
PMID: 32073931 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - February 21, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research
