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Cancer: Head and Neck Cancer
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Total 145 results found since Jan 2013.
Hepatoma-Derived Growth Factor and DDX5 Promote Carcinogenesis and Progression of Endometrial Cancer by Activating β-Catenin
Conclusion: Our results provide novel evidence that HDGF interacts with DDX5 and promotes the progression of EC through the induction of β-catenin.
Introduction
Endometrial cancer (EC) comprises the most common malignancy involving the female genital tract and the fourth most common malignancy in women after breast, lung, and colorectal cancers (1). In 2012, approximately 320,000 new cases of EC were diagnosed worldwide and the incidence is increasing (2). Currently, endometrial carcinogenesis is thought to be a multi-step process involving the coordinated interaction of hormonal regulation, gene mutation, ad...
Source: Frontiers in Oncology - April 10, 2019 Category: Cancer & Oncology Source Type: research
Induction of sestrin 2 is associated with fisetin-mediated apoptosis in human head and neck cancer cell lines.
In this study, the influence of fisetin on the growth and apoptosis of HNCCs were examined. In HSC3 cells, fisetin treatment reduced the viability and induced apoptosis. Through the results from the screening of the expression profile of apoptosis-related genes, sestrin 2 (SESN2) was functionally involved in fisetin-mediated apoptosis showing the knockdown of SESN2 by siRNA clearly restored fisetin-induced apoptosis. In addition, fisetin reduced the protein expression levels of phospho-mTOR (p-mTOR) and Mcl-1, which are the downstream molecules of SESN2. It also induced PARP cleavage by inducing an increase in the expressi...
Source: Journal of Clinical Biochemistry and Nutrition - April 3, 2019 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research
The CD98 heavy chain is a marker and regulator of head and neck squamous cell carcinoma radiosensitivity.
CONCLUSIONS:
PMID: 30670494 [PubMed - as supplied by publisher]
Source: Clin Med Res - January 22, 2019 Category: Research Authors: Digomann D, Kurth I, Tyutyunnykova A, Chen O, Löck S, Gorodetska I, Peitzsch C, Skvortsova I, Negro G, Aschenbrenner B, Eisenhofer G, Richter S, Heiden S, Porrmann J, Klink B, Schwager C, Dowle AA, Hein L, Kunz-Schughart LA, Abdollahi A, Lohaus F, Krause Tags: Clin Cancer Res Source Type: research
Targeted inactivation of EPS8 using dendrimer-mediated delivery of RNA interference
Publication date: Available online 28 December 2018Source: International Journal of PharmaceuticsAuthor(s): Quan Yuan, W. Andrew Yeudall, Eunmee Lee, Hu YangAbstractWe developed polyamidoamine dendrimers conjugated with epidermal growth factor (EGF) for use in receptor-mediated delivery of therapeutics to cancer cells. Here, we demonstrate the utility of this approach to inhibit proliferation and migration of head and neck squamous carcinoma cells through targeting of EPS8. Use of EGF-dendrimers to deliver siRNA or shRNA against EPS8 resulted in inhibition of cell growth and reduction in cell motility. Moreover, more profo...
Source: International Journal of Pharmaceutics - December 29, 2018 Category: Drugs & Pharmacology Source Type: research
Lymphotoxin ‐β receptor‐NIK signaling induces alternative RELB/NF‐κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer
This article is protected by copyright. All rights reserved
Source: Molecular Carcinogenesis - November 22, 2018 Category: Molecular Biology Authors: Rita Das,
Jamie Coupar,
Paul E. Clavijo,
Anthony Saleh,
Tsu ‐Fan Cheng,
Xinping Yang,
Jianhong Chen,
Carter VanWaes,
Zhong Chen Tags: RESEARCH ARTICLE Source Type: research
The Nedd8 ‐activating enzyme inhibitor MLN4924 (TAK‐924/Pevonedistat) induces apoptosis via c‐Myc‐Noxa axis in head and neck squamous cell carcinoma
ConclusionsThese findings determined the over ‐expression levels of neddylation enzymes in HNSCC and revealed novel mechanisms underlying neddylation inhibition induced growth suppression in HNSCC cells, which provided preclinical evidence for further clinical evaluation of neddylation inhibitors (eg, MLN4924) for the treatment of HNSCC.
Source: Cell Proliferation - October 19, 2018 Category: Cytology Authors: Wenjuan Zhang,
Yupei Liang,
Lihui Li,
Xiaofang Wang,
Zi Yan,
Changsheng Dong,
Mu ‐Sheng Zeng,
Qian Zhong,
Xue‐Kui Liu,
Jinha Yu,
Shuyang Sun,
Xiaojun Liu,
Jihui Kang,
Hu Zhao,
Lak Shin Jeong,
Yanmei Zhang,
Lijun Jia Tags: ORIGINAL ARTICLE Source Type: research
Constitutive activation and overexpression of NF- κB/c-Rel in conjunction with p50 contribute to aggressive tongue tumorigenesis.
In conclusion, selective participation of c-Rel with p50 that in cross-talk with AP-1/Fra-2 induced poor differentiation and aggressive tumorigenesis mainly in HPV-ve smokers while HPV infection induced expression of p65 and p27 leading to well differentiation and better prognosis preferably in non-smoking TSCC patients.
PMID: 30250646 [PubMed]
Source: Oncotarget - September 27, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
XIAP Limits Autophagic Degradation of Sox2 and Is A Therapeutic Target in Nasopharyngeal Carcinoma Stem Cells
Conclusion: Our study highlights the importance of IAPs in the maintenance of CSCs in NPC. Thus, XIAP is a promising therapeutic target in CSCs and suggests that NPC patients may benefit from a combination treatment of APG-1387 with conventional chemotherapy.
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Jiao Ji, Yan Yu, Zhi-Ling Li, Ming-Yuan Chen, Rong Deng, Xiang Huang, Guang-Feng Wang, Meng-Xia Zhang, Qi Yang, Senthilkumar Ravichandran, Gong-Kan Feng, Xue-Lian Xu, Chen-Lu Yang, Miao-Zhen Qiu, Lin Jiao, Dajun Yang, Xiao-Feng Zhu Tags: Research Paper Source Type: research
Long Non-coding MIR205HG Depletes Hsa-miR-590-3p Leading to Unrestrained Proliferation in Head and Neck Squamous Cell Carcinoma
Conclusions: Taken together, these findings identify a transcriptional and post-transcriptional molecular network that includes mutant p53 protein, lncMIR205HG, YAP, and other proliferation-related genes, which are enriched in HNSCC patients with poor prognosis.
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Silvia Di Agostino, Fabio Valenti, Andrea Sacconi, Giulia Fontemaggi, Matteo Pallocca, Claudio Pulito, Federica Ganci, Paola Muti, Sabrina Strano, Giovanni Blandino Tags: Research Paper Source Type: research
Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models.
Abstract
Head and neck squamous cell carcinoma (HNSCC) currently only has one FDA-approved cancer intrinsic targeted therapy, the epidermal growth factor receptor (EGFR) inhibitor cetuximab, to which only approximately 10% of tumors are sensitive. In order to extend therapy options, we subjected patient-derived HNSCC cells to small-molecule inhibitor and siRNA screens, first, to find effective combination therapies with an EGFR inhibitor, and second, to determine a potential mechanistic basis for repurposing the FDA approved agents for HNSCC. The combinations of EGFR inhibitor with anaplastic lymphoma kinase (ALK)...
Source: Cancer Biology and Therapy - June 1, 2018 Category: Cancer & Oncology Authors: Ouyang X, Barling A, Lesch A, Tyner JW, Choonoo G, Zheng C, Jeng S, West TM, Clayburgh D, Courtneidge SA, McWeeney SK, Kulesz-Martin M Tags: Cancer Biol Ther Source Type: research
Functional precision medicine identifies novel druggable targets and therapeutic options in head and neck cancer.
CONCLUSIONS: High-throughput phenotyping with siRNA and drug libraries using patient derived tumor cells prioritizes mutated driver genes and identifies novel drug targets not revealed by genomic profiling. Functional profiling is a promising adjunct to DNA sequencing for precision oncology.
PMID: 29599409 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - March 29, 2018 Category: Cancer & Oncology Authors: Xu C, Nikolova O, Basom R, Mitchell RM, Shaw R, Moser R, Park H, Gurley KE, Kao M, Green CL, Schaub FX, Diaz RL, Swan HA, Jang IS, Guinney J, Gadi VK, Margolin AA, Grandori C, Kemp CJ, Méndez E Tags: Clin Cancer Res Source Type: research
Protein phosphatase 2A (PP2A) inhibitor CIP2A indicates resistance to radiotherapy in rectal cancer
In conclusion, these results suggest that by contributing to radiosensitivity of cancer cells, low CIP2A protein expression level associates with a favorable response to long‐course (C)RT in rectal cancer patients.
Low CIP2A protein expression level associates with a favorable response to long‐course chemoradiotherapy in rectal cancer patients. Suppression of CIP2A transcription by siRNA sensitizes colorectal cancer cells to irradiation and decreases their survival in vitro.
Source: Cancer Medicine - February 14, 2018 Category: Cancer & Oncology Authors: Eva ‐Maria Birkman, Adam Elzagheid, Terhi Jokilehto, Tuulia Avoranta, Eija Korkeila, Jarmo Kulmala, Kari Syrjänen, Jukka Westermarck, Jari Sundström Tags: Original Research Source Type: research
Myosin 1b promotes cell proliferation, migration, and invasion in cervical cancer.
CONCLUSION: Taken together, our data suggested a potential role of Myo1b in cervical carcinogenesis and tumor progression and provided novel insights into the mechanism of how this factor promotes cell proliferation, migration, and invasion in CC cells.
PMID: 29395313 [PubMed - as supplied by publisher]
Source: Gynecologic Oncology - January 27, 2018 Category: Cancer & Oncology Authors: Zhang HR, Lai SY, Huang LJ, Zhang ZF, Liu J, Zheng SR, Ding K, Bai X, Zhou JY Tags: Gynecol Oncol Source Type: research
Role of β-catenin in cisplatin resistance, relapse and prognosis of head and neck squamous cell carcinoma
ConclusionFrom our results we conclude that β-catenin may contribute to HNSCC therapy resistance and disease relapse. As such, β-catenin may be explored as a therapeutic target along with conventional therapeutics.
Source: Cellular Oncology - December 14, 2017 Category: Cancer & Oncology Source Type: research
10 Knockdown of transforming growth factor beta regulator 4 (tbrg4) promotes apoptosis in human lung cancer cell line h1299 via regulating ddit3, cav1 and rrm2
AbstractTransforming growth factor beta regulator 4 (TBRG4) gene is located on 7 p14-p13, a region correlated with many cancer types, such as hematologic malignancies, head and neck squamous cell carcinoma, and multiple myeloma. However, the role of TBRG4 in human lung cancer is largely unknown. Thus, in the present study, the TBRG4 mRNA level was evaluated in the lung cancer cell line H1299 by quantitative PCR (qPCR) after knocking down TBRG4 using lentivirus-mediated small interfering RNA (siRNA). The result showed that TBRG4 was significantly inhibited in H1299 by RNAi. Microarray analysis revealed 586 differentially-ex...
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Wang, A., Liu, X., Su, W., Duan, G., Xie, Z., Chu, S. Tags: Abstracts Source Type: research
