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Cancer: Head and Neck Cancer
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Total 145 results found since Jan 2013.
Abstract 2623: PI3K/mTOR dual inhibitor PF-5212384 inhibits aberrant NF-kB activation and exhibits activity in combination with MEK inhibitor PD-325901 and docetaxel in human head and neck squamous cell carcinoma
In this study, we determined the effects of the novel PI3K-mTOR inhibitor PF-5212384 (PF-384) on molecular targets and HNSCC growth in preclinical models. PF-384 IC50s of 0.75nM-133nM were found in 12 HNSCC lines by XTT cell density assays and treatment resulted in increased sub-G0 cell death and G0/G1 phase blockade by DNA flow cytometry. PF-384 strongly inhibited direct targets of PI3K-mTOR, aberrant NF-kB transactivation and induced cytokines, but only partially inhibited MEK pathway targets. Transient siRNA knockdown of PIK3CA inhibited NF-kB activity, supporting PI3K-mTOR as an important driver and target for inhibiti...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Mohan, S., Broek, R. J. V., Saleh, A. D., Pierce, M. L., Coupar, J. F., Eytan, D. F., Chen, Z., Waes, C. V. Tags: Experimental and Molecular Therapeutics Source Type: research
Abstract 3750: Targeting PD-L1 sensitizes head and neck squamous cell carcinoma to cisplatin
In conclusion, we propose a role for PD-L1 that is distinct from the classic immunoevasion pathway. Our findings demonstrate that disruption of this protein leads to increased sensitivity of HNSCC cells to CDDP, suggesting a potential combination therapeutic strategy for patients with CDDP-resistant HNSCC.
Citation Format: Peter Qiao, Shayanne A. Lajud, Danish A. Nagda, Nobuaki Tanaka, Alyssa Civantos, Bert W. O'Malley, Daqing Li. Targeting PD-L1 sensitizes head and neck squamous cell carcinoma to cisplatin. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Qiao, P., Lajud, S. A., Nagda, D. A., Tanaka, N., Civantos, A., O'Malley, B. W., Li, D. Tags: Experimental and Molecular Therapeutics Source Type: research
Abstract 4904: {beta}-catenin silencing enhances radiation sensitivity through antagonizing effect of AMPK against Ku70/80 in head and neck cancer cells
The Wnt/β-catenin pathway regulates the cell growth and survival following radiation in various types of cancer cells. Our previous report show that activation of the Wnt/β-catenin signaling pathway is a key radioprotective mechanism in irradiated head and neck cancer (HNC) cells. However, the molecular mechanisms by which β-catenin regulates radiation sensitivity are not clear. Here we attempted to elucidate the mechanism of cell death following radiation by studying how β-catenin silencing controls the radiation sensitivity of radioresistant HNC cells.
Of nine cell lines examined, the most radioresistant cell line (A...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Chang, H. W., Nam, H. Y., Kim, M. R., Lee, H. J., Seo, J. H., Lee, S. Y., Kim, S. W., Kim, S. Y. Tags: Tumor Biology Source Type: research
Abstract 3860: Cisplatin-induced CD24 upregulation in CD44+ stem-like head and neck squamous carcinoma cells: a potential marker for unfavorable cisplatin response
Conclusion: Our work thus far, indicates that up-regulation of CD24 and the resulting phosphorylation of STAT3 upon cisplatin exposure is a phenomenon that leads to cisplatin resistance, and it could be a crucial EGFR independent STAT3 activating mechanism that needs to be explored further. In case a similar relationship in clinical specimens corroborates these in vitro findings, CD24 has the potential to be a valuable predictor of response to cisplatin in HNSCC patients as well as a therapeutic target.
Citation Format: Vishnu Modur. Cisplatin-induced CD24 upregulation in CD44+ stem-like head and neck squamous carcinoma ce...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Modur, V. Tags: Tumor Biology Source Type: research
RRM2 Regulates Bcl-2 in Head and Neck and Lung Cancers: A Potential Target for Cancer Therapy.
CONCLUSIONS: Our novel findings add to the knowledge of RRM2 in regulating expression of the anti-apoptotic protein Bcl-2 and reveal a critical link between RRM2 and Bcl-2 in apoptosis signaling.
PMID: 23719266 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - May 29, 2013 Category: Cancer & Oncology Authors: Rahman MA, Amin AR, Wang D, Koenig L, Nannapaneni S, Chen Z, Wang Z, Sica GL, Deng X, Chen ZG, Shin DM Tags: Clin Cancer Res Source Type: research
Functional genetic screens identify genes essential for tumor cell survival in head and neck and lung cancer.
CONCLUSION: This study identified a wide array of druggable genes for both lung and head and neck cancer. In particular, multiple genes involved in the G2-M checkpoint were shown to be essential for tumor cell survival, indicating their potential as anticancer targets. Clin Cancer Res; 19(8); 1994-2003. ©2013 AACR.
PMID: 23444224 [PubMed - in process]
Source: Clinical Lung Cancer - April 15, 2013 Category: Cancer & Oncology Authors: Martens-de Kemp SR, Nagel R, Stigter-van Walsum M, van der Meulen IH, van Beusechem VW, Braakhuis BJ, Brakenhoff RH Tags: Clin Cancer Res Source Type: research
Strong expression of survivin is associated with positive response to radiotherapy and improved overall survival in Head and Neck squamous cell carcinoma patients
In conclusion, our results suggest that survivin plays an important role in the response to radiotherapy and may be a useful marker for predicting radiotherapy response in patients with HNSCC. © 2013 Wiley Periodicals, Inc.
Source: International Journal of Cancer - April 6, 2013 Category: Cancer & Oncology Authors: Lovisa Farnebo, Katharina Tiefenböck, Anna Ansell, Lena K. Thunell, Stina Garvin, Karin Roberg Tags: Cancer Therapy Source Type: research
SHP2 Is Overexpressed and Inhibits pSTAT1-Mediated APM Component Expression, T-cell Attracting Chemokine Secretion, and CTL Recognition in Head and Neck Cancer Cells.
CONCLUSION: These findings suggest for the first time an important role for SHP2 in APM-mediated escape of HNC cells from CTL recognition. Targeting SHP2 could enhance T-cell-based cancer immunotherapy. Clin Cancer Res; 19(4); 1-11. ©2012 AACR.
PMID: 23363816 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - January 31, 2013 Category: Cancer & Oncology Authors: Leibowitz MS, Srivastava RM, Andrade Filho PA, Egloff AM, Wang L, Seethala RR, Ferrone S, Ferris RL Tags: Clin Cancer Res Source Type: research
Dysregulation of the repressive H3K27 trimethylation mark in head and neck squamous cell carcinoma contributes to dysregulated squamous differentiation.
CONCLUSIONS: Collectively, these data suggest that aberrant differentiation in HNSCC may be attributed to epigenetic dysregulation and suggests that inhibition of PRC2-mediated gene repression may represent a potential therapeutic target.
PMID: 23186778 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - November 27, 2012 Category: Cancer & Oncology Authors: Gannon O, Endo-Munoz LB, Merida de Long L, Hazar-Rethinam M, Saunders NA Tags: Clin Cancer Res Source Type: research
Method for Predicting and Detecting Tumor Metastasis
Detecting cancer prior to metastasis greatly increases the efficacy of treatment and the chances of patient survival. Although numerous biomarkers have been reported to identify aggressive tumor types and predict prognosis, each biomarker is specific for a particular type of cancer, and no universal marker that can predict metastasis in a number of cancers have been identified. In addition, due to a lack of reliability, several markers are typically required to determine the prognosis and course of therapy.
The inventors discovered a novel CPE splice variant designated CPE-deltaN and found its expression levels increase ac...
Source: NIH OTT Licensing Opportunities - January 5, 2009 Category: Research Authors: admin Source Type: research
