Dysregulation of the repressive H3K27 trimethylation mark in head and neck squamous cell carcinoma contributes to dysregulated squamous differentiation.

CONCLUSIONS: Collectively, these data suggest that aberrant differentiation in HNSCC may be attributed to epigenetic dysregulation and suggests that inhibition of PRC2-mediated gene repression may represent a potential therapeutic target. PMID: 23186778 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/PubMed/23186778?dopt=Abstract

Source: Clinical Cancer Research - November 27, 2012 Category: Cancer & Oncology Authors: Gannon O, Endo-Munoz LB, Merida de Long L, Hazar-Rethinam M, Saunders NA Tags: Clin Cancer Res Source Type: research