Filtered By:
Vaccination: Veterinary Vaccinations

This page shows you your search results in order of date. This is page number 18.

Order by Relevance | Date

Total 406 results found since Jan 2013.

The Wuhan Coronavirus Is Spreading Fast. Will Doctors Be Able to Find a Treatment Before the Outbreak Ends?
Cases of a novel pneumonia-like illness that originated in Wuhan, China in December have now been confirmed in South Korea, Thailand, Japan, Taiwan, Macau—and, as of Jan. 21, the U.S. The virus’ geographic reach, as well as its newly discovered ability to spread via person-to-person contact, has health officials worried about the prospect of globals spread. As health officials scramble to learn more about the virus and is origins, researchers are simultaneously turning to the question of how to develop a vaccine or therapy that could help contain transmission worldwide—a feat that experts say is technical...
Source: TIME: Health - January 22, 2020 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Infectious Disease Source Type: news

NIH-developed Zika vaccine improves fetal outcomes in animal model
(NIH/National Institute of Allergy and Infectious Diseases) An experimental Zika vaccine lowered levels of virus in pregnant monkeys and improved fetal outcomes in a rhesus macaque model of congenital Zika virus infection, according to a new study in Science Translational Medicine. Scientists developed the experimental vaccine and currently are evaluating it in a Phase 2 human clinical trial. The vaccine uses a small circular piece of DNA, or plasmid, containing genes that encode Zika virus surface proteins to induce an immune response.
Source: EurekAlert! - Infectious and Emerging Diseases - December 19, 2019 Category: Infectious Diseases Source Type: news

Broadly Protective Influenza Vaccine Comprising a Cocktail of Inactivated Avian Influenza Viruses
There is a great need for broadly protective, “universal” influenza virus vaccines given the antigenic drift and shift of influenza viruses and the variable protective efficacy of the current influenza vaccines. This technology relates to a broadly protective, “universal” influenza vaccine candidate composed of a cocktail of different l ow pathogenicity avian influenza virus subtypes inactivated by betapropiolactone (BPL). Vaccinating animals with BPL-inactivated whole virus vaccine comprising influenza virus strains belonging to four or more different low pathogenicity avian influenza hemagglutinin subtypes, intra...
Source: NIH OTT Licensing Opportunities - December 5, 2019 Category: Research Authors: ajoyprabhu3 Source Type: research

Experimental induction of respiratory syncytial virus immunopathogenesis in neonatal lambs
βThe human respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection during early childhood and infancy. There is no vaccine and very limited therapeutic options available. The mechanisms underlying the severity of RSV infection are not fully understood. Although RSV loads are correlating with disease severity, numerous studies report that an inappropriate immune response contributes to disease as well, either through an overexuberant inflammatory response, either towards a biased Th2 immune response. Recently, the neonatal lamb was proposed as a clinically relevant model of the human...
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Demoulins, T., Brügger, M., Zumkehr, B., Mehinagic, K., Posthaus, H., Summerfield, A., Ruggli, N., Alves, M. P. Tags: Allergy and immunology Source Type: research

In Silico Design and Evaluation of Acinetobacter baumannii Outer Membrane Protein a Antigenic Peptides As Vaccine Candidate in Immunized Mice.
In this study, considering the fact that outer membrane protein A is one of the most promising vaccine candidates, we predicted T cell and B cell epitopes on this protein using sequence-based epitope prediction tools and determined whether or not mice immunized with these peptides induce an immune response. We selected consensus epitopes including five peptides in different tools with the highest score. 48 female C5BL/6 SPF injected subcutaneously with the peptides (peptide1 to peptide 5 separately) in 100 μL of the solution and sham groups received adjuvant and PBS alone on the same schedule: on day 0 (primary dose) and ...
Source: Iranian Journal of Allergy, Asthma and Immunology - November 9, 2019 Category: Allergy & Immunology Authors: Mehdinejadiani K, Bandehpour M, Hashemi A, Ranjbar MM, Taheri S, Jalali SA, Mosaffa N Tags: Iran J Allergy Asthma Immunol Source Type: research

Immunogenicity Evaluation of Recombinant Edible Vaccine Candidate Containing HER2-MUC1 against Breast Cancer.
In this study, Her2, MUC1, and a novel fusion structure were expressed in the seeds and hairy roots of transgenic plants appropriately. The mice groups were immunized either by feeding of transgenic seeds or hairy roots. All immunized groups showed a considerable rise in anti-glycoprotein serum IgG and IgA, and IFNɣ cytokine. However, the animals received chimeric protein showed significant higher immune responses in comparison to ones received one of these immunogen. The results indicated that the oral immunization of an animal model with transgenic plants could effectively elicit immune responses against two major tumo...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 22, 2019 Category: Allergy & Immunology Authors: Mehrab Mohseni M, Amani J, Fasihi Ramandi M, Mahjoubi F, Jafaria M, Salmanian AH Tags: Iran J Allergy Asthma Immunol Source Type: research

Diphteria-tetanus-pertussis vaccine reduces specific IgE, inflammation and remodelling in an animal model of mite-induced respiratory allergy.
CONCLUSIONS: The DTPw vaccine reduced serum specific IgE, nasal and pulmonary inflammation and remodelling of the lower airways. PMID: 31630941 [PubMed - as supplied by publisher]
Source: Vaccine - October 16, 2019 Category: Allergy & Immunology Authors: Aun MV, Almeida FM, Saraiva-Romanholo BM, Martins MA, Kalil J, Arantes-Costa FM, Giavina-Bianchi P Tags: Vaccine Source Type: research

Recombinant Nipah F Proteins and Their Use
Nipah virus is an emerging pathogenic paramyxovirus responsible for sporadic and isolated outbreaks of severe respiratory and neurologic disease in Southern Asia. As a zoonotic virus, disease can manifest in both animals and human with indigenous fruit bats acting as natural reservoirs of the virus. The effects of viral infection vary from acute respiratory distress to fatal encephalitis. There are currently no approved therapeutics or vaccines against the virus, and growing concerns that this highly pathogenic infection has the potential to cause larger epidemics capable of inflicting significant mortality burden.Like the...
Source: NIH OTT Licensing Opportunities - August 21, 2019 Category: Research Authors: ajoyprabhu3 Source Type: research

Vaccine For Cat Allergies Developed By Swiss Scientists
ZURICH (CBS Local) — If you love cats but are allergic to them, a team of scientists in Switzerland could have the purrfect solution for you. HypoPet AG, a Swiss-based company, announced it has developed a vaccine called HypoCat that works by “immunizing cats against their own major allergen, Fel d 1.” It’s found in cat dander, and about 10 percent of humans are allergic to it, according to the Journal of Allergy and Clinical Immunology. “Our HypoCat vaccine is able to produce high levels of antibodies in cats,” HypoPet AG CEO Gary Jennings wrote in a statement. “These antibodies can b...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - August 16, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Offbeat Local TV talkers Source Type: news

Preventing iatrogenic gelatin anaphylaxis
Gelatin is an animal-derived proteinaceous substance found in foods, cosmetics, and medical supplies. It is generated by partial hydrolysis and treatment of collagen, commonly porcine or bovine. The result is a heterogenous mixture of water-soluble proteins with gel-forming properties that lends its texture to foods like marshmallows and jellies.1,2 This and other properties have been exploited for medical purposes such as in pill capsules, hemostatic agents, and vaccines.3 For people who are allergic to gelatin, the pervasive and sometimes hidden nature of this allergen in medical supplies presents a unique problem and a ...
Source: Annals of Allergy, Asthma and Immunology - July 24, 2019 Category: Allergy & Immunology Authors: Yike Jiang, Irene H. Yuan, Emily K. Dutille, Rebecca Bailey, Marcus S. Shaker Tags: Review Source Type: research

New toxicity testing of PQ grass allergy immunotherapy to support product development
AbstractPQ Grass represents an allergen ‐specific immunotherapy for pre‐seasonal treatment of patients with seasonal allergic rhinitis (or rhinoconjunctivitis) with or without mild‐to‐moderate bronchial asthma. It consists of a native pollen extract for 13 grass species, chemically modified with glutaraldehyde, and adsorbed tol‐tyrosine in a microcrystalline form with addition of the adjuvant Monophosphoryl Lipid A (MPL®). Previous non ‐clinical safety testing, including rat repeat dose toxicity in adult and juvenile animals, rat reproductive toxicity and rabbit local tolerance studies showed no safety finding...
Source: Journal of Applied Toxicology - June 22, 2019 Category: Toxicology Authors: Paul Baldrick, James W. Hutchings, Matthew D. Heath, Murray A. Skinner, Tom Martin, Chris Gray Tags: RESEARCH ARTICLE Source Type: research

Continuous Cell Lines Persistently Expressing High Levels of Native HIV-1 Envelope Trimers on their Surface Membrane
Transduced human cell lines expressing high levels of native HIV-1 Envelope on their surface membrane, in the unmodified or interdomain stabilized form. These cell lines provide a stable source of native HIV-1 envelope for multiple uses, including the high-efficiency production of virus-like particles (VLPs) for use as vaccines, testing new inhibitors or neutralizing antibodies, or identifying/capturing B cells that produce broadly neutralizing antibodies from infected/vaccinated humans or animals.This technology is available for licensing for commercial development in accordance with 35 U.S.C. § 209 and 37 CFR Part 404, ...
Source: NIH OTT Licensing Opportunities - May 20, 2019 Category: Research Authors: ajoyprabhu3 Source Type: research

Leukocyte Heparanase: A Double-Edged Sword in Tumor Progression
Conclusions This review describes how leukocyte-heparanase can be a double-edged sword in tumor progression; it can enhance tumor immune surveillance and tumor cell clearance, but also promote tumor survival and growth. We also discuss the potential of using heparanase in leukocyte therapies against tumors, and the effects of heparanase inhibitors on tumor progression and immunity. We are just beginning to understand the influence of heparanase on a pro/anti-tumor immune response, and there are still many questions to answer. How do the pro/anti-tumorigenic effects of heparanase differ across different cancer types? Does...
Source: Frontiers in Oncology - April 29, 2019 Category: Cancer & Oncology Source Type: research

Non-classical B Cell Memory of Allergic IgE Responses
Sean P. Saunders1, Erica G. M. Ma1,2, Carlos J. Aranda1 and Maria A. Curotto de Lafaille1,3* 1Division of Pulmonary, Critical Care and Sleep Medicine, Laboratory of Allergy and Inflammation, Department of Medicine, New York University, New York, NY, United States 2Sackler Institute of Graduate Biomedical Sciences, New York University, New York, NY, United States 3Department of Cell Biology, New York University School of Medicine, New York, NY, United States The long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma ce...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research