Continuous Cell Lines Persistently Expressing High Levels of Native HIV-1 Envelope Trimers on their Surface Membrane

Transduced human cell lines expressing high levels of native HIV-1 Envelope on their surface membrane, in the unmodified or interdomain stabilized form. These cell lines provide a stable source of native HIV-1 envelope for multiple uses, including the high-efficiency production of virus-like particles (VLPs) for use as vaccines, testing new inhibitors or neutralizing antibodies, or identifying/capturing B cells that produce broadly neutralizing antibodies from infected/vaccinated humans or animals.This technology is available for licensing for commercial development in accordance with 35 U.S.C. § 209 and 37 CFR Part 404, as well as for further development and evaluation under a research collaboration.IC: NIAIDNIH Ref. No.: E-185-2018-0Advantages: The interdomain-stabilized form does not bind CD4 and is locked in the native prefusion formApplications: High-efficiency production of virus-like particles (VLPs)A means to test new inhibitors or neutralizing antibodies targeting HIV-1 envelope trimersProbe for identifying/capturing B cells that produce broadly neutralizing antibodiesProvider Technology ID: 3370Updated On: May 20, 2019Date Published: Monday, May 20, 2019Provider Classifications: Publications: 2019-07-23 00:00:002019-07-23 00:00:00Licensing Contacts: LPM Address:   --United StatesLead Inventor: Inventor IC: NIAIDNIAIDInventor Lab URL: http://irp.nih.gov/pi/paolo-lussoLPM FIrst Name: Christo...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research