Recombinant Nipah F Proteins and Their Use

Nipah virus is an emerging pathogenic paramyxovirus responsible for sporadic and isolated outbreaks of severe respiratory and neurologic disease in Southern Asia. As a zoonotic virus, disease can manifest in both animals and human with indigenous fruit bats acting as natural reservoirs of the virus. The effects of viral infection vary from acute respiratory distress to fatal encephalitis. There are currently no approved therapeutics or vaccines against the virus, and growing concerns that this highly pathogenic infection has the potential to cause larger epidemics capable of inflicting significant mortality burden.Like the RSV fusion (F) glycoprotein, the Nipah fusion glycoprotein is a target of neutralizing antibodies that mediate protection against infection. Previous studies of prefusion-stabilized F glycoproteins from pneumoviruses and other paramyxoviruses (e.g. RSV and PIVs) have shown they elicit higher titers of neutralizing antibodies in both animals and humans than post-fusion F proteins.Researchers at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID) designed disulfide, cavity-filling and other mutations that stabilize the Nipah F glycoprotein in the prefusion conformation and bind prefusion-specific antibodies. These mutations also increase protein expression yields up to 50-fold making the recombinant proteins easy to manufacture and amenable to the use of genetic immunization using nucleic acid or vector-based...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research

Related Links:

The cause of beta-lactam adverse events could not be determined in most patients with negative skin tests.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Allergy & Clinical Immunology News Source Type: news
' Studies like this give us hope that we will be able to prevent food allergies,'said one allergy specialist who was not involved in the study.Medscape Medical News
Source: Medscape Gastroenterology Headlines - Category: Gastroenterology Tags: Allergy & Clinical Immunology News Source Type: news
Papers released by SAGE and subgroup Nervtag warned the highly evolved Omicron super mutant strain could cause a surge in cases 'similar or even larger' than previous waves.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Brazilian President Jair Bolsonaro is facing a potential investigation into comments linking COVID-19 vaccines to AIDS
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
A new mathematical analysis strengthens concerns about the effects of the new variant on the pandemic ’s course.
Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Coronavirus Omicron Variant Coronavirus (2019-nCoV) Vaccination and Immunization Immune System South Africa Coronavirus Delta Variant Disease Rates Source Type: news
The Kaiser Family Foundation vaccine monitor finds that only 39 percent of women that are either pregnant or plan to be soon are confident in the safety of the Covid vaccines.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
DR MICHAEL MOSLEY: I recently had to tell a friend, who has chosen not to get vaccinated, that he is no longer welcome to a small social gathering I've organised next week.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Cost of therapy and the need for repeated injections are barriers to omalizumab's adjunctive role.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Allergy & Clinical Immunology News Source Type: news
A new study examines factors that promote and obstruct vaccine access and acceptance as well as what can be done to promote more uptake of COVID-19 vaccines.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
The Pittsburgh-based health system, which is owned by Highmark Health, confirmed to the Business Times earlier this week that it had no plans to change its mandate.
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
More News: Allergy | Allergy & Immunology | Brain | Encephalitis | Epidemics | Epidemiology | Fruit | Genetics | Infectious Diseases | Nanotechnology | Neurology | Nipah Virus | Outbreaks | Pneomococcal Vaccine | Research | Respiratory Medicine | Study | Vaccines | Veterinary Vaccinations | Zoonoses