Leukocyte Heparanase: A Double-Edged Sword in Tumor Progression

Conclusions This review describes how leukocyte-heparanase can be a double-edged sword in tumor progression; it can enhance tumor immune surveillance and tumor cell clearance, but also promote tumor survival and growth. We also discuss the potential of using heparanase in leukocyte therapies against tumors, and the effects of heparanase inhibitors on tumor progression and immunity. We are just beginning to understand the influence of heparanase on a pro/anti-tumor immune response, and there are still many questions to answer. How do the pro/anti-tumorigenic effects of heparanase differ across different cancer types? Does the tumorigenic effect of heparanase change during cancer progression? And how does the expression or role of heparanase change during treatment regimens? Answering these questions may help guide the appropriate use of heparanase inhibitors, and the use of heparanase-assisted therapies for the treatment of cancer. Author Contributions All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication. Funding This research was supported by project grants from the National Health and Medical Research Council of Australia (APP471424) and the Association for International Cancer Research (#08-0215). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of intere...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

We report a rare case of 74-year-old female of primary hyperparathyroidism caused by parathyroid carcinoma (PC) and coexisting multiple parathyroid adenomas. She was referred to our hospital for primary hyperparathyroidism and a suspected thyroid tumor. She had no family history of malignant tumor. Computed tomography (CT) and ultrasonography of the neck revealed some masses posterior to both thyroid lobes. Those masses were believed to be parathyroid lesions. However, another mass located posterior to the right upper thyroid lobe seemed to be heterogeneous, which indicated a malignant thyroid tumor as well as parathyroid ...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
We describe a unique, complex case of a man resulted affected by both APS-2 and MEN-2a. The patient developed Hashimoto's thyroiditis, diabetes mellitus type 1 and AAD, despite testing negative for adrenal cortex autoantibodies (ACA) and steroid 21-hydroxylase autoantibodies (21-OHAb). Moreover, he had also a family history for MEN-2a and he first developed medullay thyroid cancer, then bilateral pheochromocytoma on the adrenal substrate of an AAD. On adrenal histology we found complete bilateral cortical atrophy in the presence of a lymphocytic infiltration and fibrosis, confirming an ACA and 21-OHAb-negative AAD. This da...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
CONCLUSIONS: The ATA risk stratification system is a reliable predictor of short-term outcomes in patients with DTC in real-world clinical settings characterized by center heterogeneity in terms of size, location, level of care, local management strategies, and resource availability. PMID: 32475305 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
In conclusion, we suggest that in the presence of intolerance or resistance to colchicine, interleukin (IL)-1 inhibition could suppress peritoneal inflammation and prevent MSTs. PMID: 32477360 [PubMed - in process]
Source: Pain Physician - Category: Anesthesiology Authors: Tags: Front Immunol Source Type: research
CONCLUSION: Inpatient consultations is very useful to the patient and managing physician. Although a better knowledge in the identification of common ophthalmic conditions can help to reduce the number of inpatient consults from other medical specialties. PMID: 32476114 [PubMed - in process]
Source: Pain Physician - Category: Anesthesiology Authors: Tags: West Afr J Med Source Type: research
Conclusions: MPO-ANCA-positive patients with ILD do not show the typical UIP pattern as seen in patients with idiopathic pulmonary fibrosis on surgical lung biopsy. PMID: 32476954 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research
In the original article, the units indicated on the y-axes of Fig.  3 are incorrectly labelled. The correct label is pg/mL. Following is the corrected Fig. 3.
Source: World Journal of Surgery - Category: Surgery Source Type: research
Source: World Journal of Surgery - Category: Surgery Source Type: research
Source: World Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 1 June 2020Source: Pathology - Research and PracticeAuthor(s): Zhi-Yun Zhang, Meng Lu, Ze-Kun Liu, Hao Li, Yu-Le Yong, Ren-Yu Zhang, Zhi-Nan Chen, Huijie Bian
Source: Pathology Research and Practice - Category: Pathology Source Type: research
More News: Academia | Acute Leukemia | Acute Lymphoblastic Leukemia | Adenoviruses | AIDS Vaccine | Allergy | Allergy & Immunology | Arthritis | Asbestosis | Australia Health | Autoimmune Disease | Biochemistry | Biotechnology | Brain | Brain Cancers | Brain Tumor | Brazil Health | Breast Cancer | Breast Carcinoma | Cancer | Cancer & Oncology | Cancer Therapy | Cancer Vaccines | Carcinoma | Cardiology | Chemistry | Chemotherapy | China Health | Chronic Leukemia | Clinical Trials | Colon Cancer | Colorectal Cancer | Crohn's Disease | Cystic Fibrosis | Diabetes | Diabetes Type 1 | Encephalitis | Endocrinology | Epithelial Cancer | Esophagus Cancer | Gastric (Stomach) Cancer | Gastroenterology | Gene Therapy | Genetics | Germany Health | Glioma | Grants | Head and Neck Cancer | Heart | Hematology | Hemorrhagic Stroke | Hepatocellular Carcinoma | HIV AIDS | Immunotherapy | Infectious Diseases | Inflammatory Bowel Disease | Italy Health | Lessons | Leukemia | Liver | Liver Cancer | Lung Cancer | Lymphoma | Melanoma | Mesothelioma | Myeloma | Neuroblastoma | Neurology | Neuroscience | Non-Small Cell Lung Cancer | Ovarian Cancer | Ovaries | Pancreas | Pancreatic Cancer | Pancreatitis | Pituitary Tumor | Pneomococcal Vaccine | Pneumonia | Reproduction Medicine | Research | Rheumatoid Arthritis | Rheumatology | Science | Skin Cancer | Study | Subarachnoid Hemorrhage | Thrombocytopenia | Thyroid | Thyroid Cancer | Toxicology | Translocation | Urology & Nephrology | Vaccines | Veterinary Vaccinations | Virotherapy