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Total 338 results found since Jan 2013.

Frequency of Circulatory Regulatory Immune Cells in Iranian Patients with Type 1 Diabetes.
Abstract Type 1 diabetes (T1D) is the result of the autoimmune destruction of insulin-producing beta cells. Regulatory T cells (Tregs) and plasmacytoid dendritic cells (PDCs) act as mediators of peripheral tolerance. We investigated the possible alterations of such cells in peripheral blood of patients with T1D compared to normal individuals. This comparison may lead to a better understanding of the immunopathogenesis processes involved in T1D. 92 participants, including 49 patients with T1D and 43 healthy controls were studied. 3 mL of blood was taken from all participants. After isolating peripheral blood mononu...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2017 Category: Allergy & Immunology Authors: Khamehchian T, Nemati E, Jazayeri M, Azimi S, Nikoueinejad H, Akbari H, Irandoust B Tags: Iran J Allergy Asthma Immunol Source Type: research

Effect of Liraglutide on Type B Insulin Resistance Syndrome and Insulin Allergy in Type 2 Diabetes: A Case Report
ConclusionLiraglutide may be a therapeutic option for patients with insulin allergy, anti-insulin antibodies, and type B insulin resistance syndrome, as it represents an alternative strategy to insulin.
Source: Diabetes Therapy - August 23, 2017 Category: Endocrinology Source Type: research

Subcutaneous Injectable Drugs Hypersensitivity and Desensitization
Injectable drugs, including monoclonal antibodies, are becoming crucial components in the management of chronic diseases. The most common side effects are local reactions at the site of administration. With the increased and prolonged use of these medications, we are seeing increased reports of hypersensitivity reactions. The aim of this article is to discuss the signs and symptoms of these reactions as well as management, which may involve desensitization for 3 commonly encountered injectable drugs: tumor necrosis factor- α inhibitors (etanercept and adalimumab), insulin, and omalizumab.
Source: Immunology and Allergy Clinics of North America - August 18, 2017 Category: Allergy & Immunology Authors: Sevim Bavbek, Min Jung Lee Source Type: research

The plight of protamine for heparin reversal in sensitized individuals
Conclusions Identification of patient risk factors prior to protamine administration could result in (1) avoidance of protamine administration or (2) improved preparation for potential anaphylaxis.
Source: Polish Annals of Medicine - July 4, 2017 Category: General Medicine Source Type: research

Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity
Conclusions: In the present study, we observed that early life exposure to PM2.5 may play an important role in the early life origins of COWO and may increase the risk of COWO in children of mothers who were overweight or obese before pregnancy beyond the risk that can be attributed to MPBMI alone. Our findings emphasize the clinical and public health policy relevance of early life PM2.5 exposure. https://doi.org/10.1289/EHP261 Received: 29 March 2016 Revised: 08 August 2016 Accepted: 23 August 2016 Published: 14 June 2017 Address correspondence to X. Wang, Center on the Early Life Origins of Disease, Department of P...
Source: EHP Research - June 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Beyond epithelial ‐to‐mesenchymal transition: common suppression of differentiation programs underlies epithelial barrier dysfunction in mild, moderate and severe asthma
ConclusionsThe comparative analysis of publically available transcriptomes demonstrated that epithelial barrier dysfunction in asthma is characterized by persistent underlying de‐differentiation program with complex etiology. The lasting alteration of the asthmatic epithelial cell transcriptome implicates regulation involving metabolism and epigenetics, beyond EMT driven by injury and repair in chronic inflammation.This article is protected by copyright. All rights reserved.
Source: Allergy - June 9, 2017 Category: Allergy & Immunology Authors: Lucas F. Loffredo, Hiam Abdala ‐Valencia, Kishore R. Anekalla, Lyda Cuervo‐Pardo, Cara J. Gottardi, Sergejs Berdnikovs Tags: Original Article: Airway Diseases Source Type: research

8 Things You Need To Know About Your Body's Energy Levels
By Hallie Levine Your energy makeover starts now It’s no wonder so many of us struggle with energy issues. We go, go, go from morning to night, running on little but grit and caffeine. But it doesn’t have to be that way! “The reality is, you can get a real boost by making a few simple changes,” says Nada Milosavljevic, MD, director of the integrative health program at Massachusetts General Hospital. That’s why we put together this complete guide to all-day energy: It’s packed with proven strategies that will keep you powered up as you plow through your to-do list. You’ll also learn...
Source: Healthy Living - The Huffington Post - May 4, 2017 Category: Consumer Health News Source Type: news

Use of Flash Glucose-Sensing Technology for 12  months as a Replacement for Blood Glucose Monitoring in Insulin-treated Type 2 Diabetes
ConclusionThe use of flash glucose-sensing technology for glycemic management in individuals with type 2 diabetes treated by intensive insulin therapy over 12  months was associated with a sustained reduction in hypoglycemia and safely and effectively replaced SMBG.Trial RegistrationClinicalTrials.gov identifier, NCT02082184.
Source: Diabetes Therapy - April 11, 2017 Category: Endocrinology Source Type: research

Long-acting insulin allergy in a diabetic child.
Authors: Mastrorilli C, Rizzuti L, Cangelosi AM, Iovane B, Chiari G, Caffarelli C Abstract Insulin allergy has been uncommon since the introduction of human recombinant insulin preparations; the prevalence is 2.4%. Insulin injection could elicit immediate reactions, which are usually induced by an IgE-mediated mechanism, within the first hour after drug administration. In the present study, we describe the case of a child who experienced immediate urticaria after long-acting insulin injection. A 9-year-old girl affected by type I diabetes mellitus referred a history of three episodes of urticaria 30 min after insul...
Source: International Journal of Immunopathology and Pharmacology - April 5, 2017 Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research

Cutaneous Manifestations of Diabetes Mellitus: A Review
AbstractDiabetes mellitus is a widespread endocrine disease with severe impact on health systems worldwide. Increased serum glucose causes damage to a wide range of cell types, including endothelial cells, neurons, and renal cells, but also keratinocytes and fibroblasts. Skin disorders can be found in about one third of all people with diabetes and frequently occur before the diagnosis, thus playing an important role in the initial recognition of underlying disease. Noninfectious as well as infectious diseases have been described as dermatologic manifestations of diabetes mellitus. Moreover, diabetic neuropathy and angiopa...
Source: American Journal of Clinical Dermatology - April 3, 2017 Category: Dermatology Source Type: research

Amino Acid–based Formula in Cow's Milk Allergy: Long-term Effects on Body Growth and Protein Metabolism
Objectives: The long-term effects of amino acid–based formula (AAF) in the treatment of cow's milk allergy (CMA) are largely unexplored. The present study comparatively evaluates body growth and protein metabolism in CMA children treated with AAF or with extensively hydrolyzed whey formula (eHWF), and healthy controls. Methods: A 12-month multicenter randomized control trial was conducted in outpatients with CMA (age 5–12 m) randomized in 2 groups, treated with AAF (group 1) and eHWF (group 2), and compared with healthy controls (group 3) fed with follow-on (if age 12 months). At enrolment (T0), after 3 (T3), 6 (T6), ...
Source: Journal of Pediatric Gastroenterology and Nutrition - March 25, 2017 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

The effect of obesity, weight gain, and weight loss on asthma inception and control
Purpose of review: There is ample and growing evidence that obesity increases the risk of asthma and morbidity from asthma. Here, we review recent clinical evidence supporting a causal link between obesity and asthma, and the mechanisms that may lead to ‘obese asthma’. Recent findings: Although in some children obesity and asthma simply co-occur, those with ‘obese asthma’ have increased asthma severity, lower quality of life, and reduced medication response. Underlying mechanistic pathways may include anatomical changes of the airways such as obstruction and dysanapsis, systemic inflammation, production of adipoki...
Source: Current Opinion in Allergy and Clinical Immunology - February 23, 2017 Category: Allergy & Immunology Tags: PEDIATRIC ASTHMA AND DEVELOPMENT OF ATOPY: Edited by Leonard B. Bacharier and Stanley J. Szefler Source Type: research

Metformin reduces weight gain in overweight/obese adolescents with type 1 diabetes
Commentary on: Libman IM, Miller KM, DiMeglio LA, et al.., T1D Exchange Clinic Network Metformin RCT Study Group. Effect of metformin added to insulin on glycemic control among overweight/obese adolescents with type 1 diabetes: a randomized clinical trial. JAMA 2015;314:2241–50 . Context Weight gain in individuals with type 1 diabetes (T1D) is associated with an increase in other cardiovascular risk factors (eg, hypertension, dyslipidaemia) and increasing insulin resistance, often requiring higher doses of insulin to maintain adequate glycaemic control. The goal of the current study was to explore the use of metformi...
Source: Evidence-Based Medicine - September 22, 2016 Category: Internal Medicine Authors: Sharma, A. M. Tags: Clinical trials (epidemiology), Immunology (including allergy), Hypertension, Obesity (nutrition), Diabetes, Health education Therapeutics/Prevention Source Type: research

Novel glucose-sensing technology and hypoglycaemia in type 1 diabetes: a multicentre, non-masked, randomised controlled trial
Publication date: Available online 12 September 2016 Source:The Lancet Author(s): Jan Bolinder, Ramiro Antuna, Petronella Geelhoed-Duijvestijn, Jens Kröger, Raimund Weitgasser Background Tight control of blood glucose in type 1 diabetes delays onset of macrovascular and microvascular diabetic complications; however, glucose levels need to be closely monitored to prevent hypoglycaemia. We aimed to assess whether a factory-calibrated, sensor-based, flash glucose-monitoring system compared with self-monitored glucose testing reduced exposure to hypoglycaemia in patients with type 1 diabetes. Method In this multicentre, pros...
Source: The Lancet - September 11, 2016 Category: Journals (General) Source Type: research

Progress in pediatrics in 2015: choices in allergy, endocrinology, gastroenterology, genetics, haematology, infectious diseases, neonatology, nephrology, neurology, nutrition, oncology and pulmonology
AbstractThis review focuses key advances in different pediatric fields that were published in Italian Journal of Pediatrics and in international journals in 2015. Weaning studies continue to show promise for preventing food allergy. New diagnostic tools are available for identifying the allergic origin of allergic-like symptoms. Advances have been reported in obesity, short stature and autoimmune endocrine disorders. New molecules are offered to reduce weight gain and insulin-resistance in obese children. Regional investigations may provide suggestions for preventing short stature. Epidemiological studies have evidenced th...
Source: Italian Journal of Pediatrics - August 26, 2016 Category: Pediatrics Source Type: research