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Drug: Insulin
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Total 338 results found since Jan 2013.
Induced Pluripotent Stem-cells Inhibit Experimental Bleomycin-induced Pulmonary Fibrosis through Regulation of the Insulin-like Growth Factor Signaling
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):263-272. doi: 10.18502/ijaai.v21i3.9800.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is among the illnesses with a high mortality rate, yet no specific cause has been identified; as a result, successful treatment has not been achieved. Among the novel approaches for treating such hard-to-cure diseases are induced pluripotent stem cells (IPSCs). Some studies have shown these cells' potential in treating IPF. Therefore, we aimed to investigate the impact of IPSCs on insulin-like growth factor (Igf) signaling as a major contributor to IPF pathogenesis. C57BL/6 mice were intratra...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Paria Bayati Marjan Taherian Mohammad-Ali Assarehzadegan Mansoureh Soleimani Hadi Poormoghim Nazanin Mojtabavi Source Type: research
Prevalence and associations among metabolically unhealthy obesity, asthma exacerbations, and emergency department use
Helper type 1 T cell polarization and monocyte cell activation influence forced expiratory volume in 1 second/forced vital capacity and are affected by body mass index (BMI), insulin resistance, and serum lipoproteins. No study has assessed the impact of metabolic syndrome components on asthma symptom control.
Source: Annals of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Benjamin Greiner, Micah Hartwell Tags: Original Article Source Type: research
Prevalence and associations between metabolically unhealthy obesity and asthma exacerbations and emergency department usage
Th1 cell polarization and monocyte cell activation influence FEV1/FVC and are affected by body mass index (BMI), insulin resistance, and serum lipoproteins. No study has assessed the impact of metabolic syndrome components on asthma symptom control.
Source: Annals of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Benjamin Greiner, Micah Hartwell Source Type: research
Diabetes Devices May Give Kids Contact Dermatitis Diabetes Devices May Give Kids Contact Dermatitis
Insulin pumps and glucose devices improve the lives of children with diabetes, but they may also contain allergens that cause contact dermatitis, according to researchers in Denmark.Medscape Medical News
Source: Medscape Medical News Headlines - June 30, 2022 Category: Consumer Health News Tags: Allergy & Clinical Immunology News Source Type: news
Serious diabetic ketoacidosis induced by insulin allergy and anti ‐insulin antibody in an individual with type 2 diabetes mellitus
We showed a case with serious diabetic ketoacidosis induced by insulin allergy and anti-insulin antibody in a subject with type 2 diabetes mellitus. This case suggests that once we use exogenous human insulin and/or insulin-analog, multiple classes of antibodies against insulin, such as IgE and IgG antibodies, can be induced simultaneously. Moreover, this case showed that we should know that since insulin requirement may be very high under severe insulin resistance and serious DKA, we have to increase insulin dose without hesitation while monitoring pH, BE and other factors in order to save their lives. ABSTRACTDiabetic ke...
Source: Journal of Diabetes Investigation - June 1, 2022 Category: Endocrinology Authors: Kaio Takahashi,
Takatoshi Anno,
Haruka Takenouchi,
Hideyuki Iwamoto,
Megumi Horiya,
Yukiko Kimura,
Fumiko Kawasaki,
Kohei Kaku,
Koichi Tomoda,
Hideaki Kaneto Tags: Case Report Source Type: research
Serious diabetic ketoacidosis induced by insulin allergy and anti ‐insulin antibody in a subject with type 2 diabetes mellitus
AbstractDiabetic ketoacidosis (DKA) is one of the most serious acute metabolic complications of diabetes mellitus (DM), and characterized by hyperglycemia, metabolic acidosis, and increased total ketone body concentrations. The main mechanism of DKA is a lack of insulin in the body. It has been reported that some immunological response is associated with insulin therapy. Herein, we report a case of serious DKA, which was induced by insulin allergy and anti-insulin antibody. This case clearly indicates that DKA can be induced by insulin allergy and anti-insulin antibodies in subjects with T2DM treated with insulin. Moreover...
Source: Journal of Diabetes Investigation - May 19, 2022 Category: Endocrinology Authors: Kaio Takahashi,
Takatoshi Anno,
Haruka Takenouchi,
Hideyuki Iwamoto,
Megumi Horiya,
Yukiko Kimura,
Fumiko Kawasaki,
Kohei Kaku,
Koichi Tomoda,
Hideaki Kaneto Tags: CASE REPORT Source Type: research
Insulin allergy: a diagnostic and therapeutic strategy based on a retrospective cohort and a case –control study
Conclusions/interpretationSubject to validation, clinical likelihood criteria can effectively guide diabetologists towards an insulin allergy diagnosis before undertaking allergology tests. An IDR test shows the best diagnostic performance. A progressive management strategy can subsequently be implemented. Continuous subcutaneous insulin infusion is ultimately required in most patients.ClinicalTrials.gov: NCT01407640.Graphical abstract
Source: Diabetologia - May 4, 2022 Category: Endocrinology Source Type: research
Technologies for Type 1 Diabetes and Contact Dermatitis: Therapeutic Tools and Clinical Outcomes in a Cohort of Pediatric Patients
The increasing use of technological devices for the management of diabetes is related to the prolonged exposure of patients’ skin to chemical and mechanical agents and, consequently, to the increased risk of developing dermatological complications. Among these, contact dermatitis is the most insidious skin disorder. Despite the magnitude of the issue, no universally accepted recommendations on the management of this common complication are currently available. Our observational study aimed to describe all the solutions adopted by patients and their caregivers to treat and prevent the appearance of contact dermatitis and ...
Source: Frontiers in Endocrinology - March 15, 2022 Category: Endocrinology Source Type: research
