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Drug: Insulin

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Total 338 results found since Jan 2013.

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance
CONCLUSION: We demonstrate impaired immunity following SARS-CoV-2 mRNA immunization in a murine model of comorbid T2DM and obesity, supporting the need for further research into the basis for impaired anti-SARS-CoV-2 immunity in T2DM and investigation of novel approaches to enhance vaccine immunogenicity among those with metabolic diseases.PMID:37595760 | DOI:10.1016/j.jaci.2023.06.031
Source: Clinical Lung Cancer - August 18, 2023 Category: Cancer & Oncology Authors: Timothy R O'Meara Etsuro Nanishi Marisa E McGrath Soumik Barman Danica Dong Carly Dillen Manisha Menon Hyuk-Soo Seo Sirano Dhe-Paganon Robert K Ernst Ofer Levy Matthew B Frieman David J Dowling Source Type: research

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.
Obesity and type 2 diabetes impair SARS-CoV-2 mRNA vaccine efficacy in a murine model.
Source: Journal of Allergy and Clinical Immunology - August 16, 2023 Category: Allergy & Immunology Authors: Timothy R. O ’Meara, Etsuro Nanishi, Marisa E. McGrath, Soumik Barman, Danica Dong, Carly Dillen, Manisha Menon, Hyuk-Soo Seo, Sirano Dhe-Paganon, Robert K. Ernst, Ofer Levy, Matthew B. Frieman, David J. Dowling Source Type: research

Pharmacological Action of Baicalin on Gestational Diabetes Mellitus in Pregnant Animals Induced by Streptozotocin via AGE-RAGE Signaling Pathway
CONCLUSION: Baicalin demonstrated the potential impact on the embryo's development via the AGE-RAGE signaling pathway in STZ-induced GDM pregnant animals.PMID:37436545 | DOI:10.1007/s12010-023-04586-8
Source: Applied Biochemistry and Biotechnology - July 12, 2023 Category: Biochemistry Authors: Shuqiong Qiu Xiaojie Wu Qingke Wu Xin Jin Huirong Li Rupak Roy Source Type: research

33% of Type 1 Diabetes Patients Insulin-Free With Stem Cells 33% of Type 1 Diabetes Patients Insulin-Free With Stem Cells
Engraftment of Vertex Pharmaceutical ' s VX-880 stem cell –derived islets has now been achieved in six patients, two of whom are insulin-independent at 1 year.Medscape Medical News
Source: Medscape Allergy Headlines - July 3, 2023 Category: Allergy & Immunology Tags: Diabetes & Endocrinology News Source Type: news

Old Drug Verapamil May Have New Use in Type 1 Diabetes Old Drug Verapamil May Have New Use in Type 1 Diabetes
In randomized trial, the old cardiac agent slowed the destruction of insulin-producing beta cells in youth with new-onset type 1 diabetes.Medscape Medical News
Source: Medscape Allergy Headlines - February 27, 2023 Category: Allergy & Immunology Tags: Diabetes & Endocrinology News Source Type: news

Skin Problems Common at Insulin Pump Infusion Sites Skin Problems Common at Insulin Pump Infusion Sites
Tissue changes from inflammatory responses could be responsible for infusion site failures.First Look
Source: Medscape Allergy Headlines - February 24, 2023 Category: Allergy & Immunology Tags: Diabetes & Endocrinology News Source Type: news

Type 2 Inflammation Drives an Airway Basal Stem Cell Program Through Insulin Receptor Substrate Signaling
Type 2 cytokines drive an airway stem cell program through IRS signaling
Source: Journal of Allergy and Clinical Immunology - February 16, 2023 Category: Allergy & Immunology Authors: Xin Wang, Nils R. Hallen, Minkyu Lee, Sachin Samuchiwal, Qihua Ye, Kathleen M. Buchheit, Alice Z. Maxfield, Rachel E. Roditi, Regan W. Bergmark, Neil Bhattacharyya, Tessa Ryan, Deb Gakpo, Soumya Raychaudhuri, Dan Dwyer, Tanya M. Laidlaw, Joshua A. Boyce, Source Type: research

Mast cell –mediated inflammation relies on insulin-regulated aminopeptidase controlling cytokine export from the Golgi
On activation, mast cells rapidly release preformed inflammatory mediators from large cytoplasmic granules via regulated exocytosis. This acute degranulation is followed by a late activation phase involving synthesis and secretion of cytokines, growth factors, and other inflammatory molecules via the constitutive pathway that remains ill defined.
Source: Journal of Allergy and Clinical Immunology - January 25, 2023 Category: Allergy & Immunology Authors: Mirjana Weimershaus, Caroline Carvalho, Rachel Rignault, Emmanuelle Waeckel-Enee, Michael Dussiot, Peter van Endert, Thiago Trovati Maciel, Olivier Hermine Source Type: research

Mast cell-mediated inflammation relies on insulin-regulated aminopeptidase controlling cytokine export from the Golgi
IRAP endosomes are required for the efficient secretion of proinflammatory cytokines by mast cells in mice.
Source: Journal of Allergy and Clinical Immunology - January 25, 2023 Category: Allergy & Immunology Authors: Mirjana Weimershaus, Caroline Carvalho, Rachel Rignault, Emmanuelle Waeckel-Enee, Michael Dussiot, Peter van Endert, Thiago Trovati Maciel, Olivier Hermine Source Type: research

Residual Beta-Cell Function May Protect Kidneys in Type 1 Diabetes Residual Beta-Cell Function May Protect Kidneys in Type 1 Diabetes
Over half of participants still had insulin secretion beyond 3 years after diagnosis.First Look
Source: Medscape Allergy Headlines - January 18, 2023 Category: Allergy & Immunology Tags: Diabetes & Endocrinology News Source Type: news

Insulin allergy manifesting soon after COVID ‐19 vaccination (BNT162b2)
We experienced a case with insulin allergy which manifested soon after COVID-19 vaccination.
Source: Journal of Diabetes Investigation - December 24, 2022 Category: Endocrinology Authors: Hiroshi Komamura, Yohei Kawana, Junta Imai, Hideki Katagiri Tags: Letter to the Editor Source Type: research

High Insulin in Early Childhood Is Associated With Subsequent Asthma Risk Independent of Body Mass Index
Carr   TF,  Granell  R,  Stern  DA. J Allergy Clin Immunol Pract. 2022;10(3):785–791
Source: PEDIATRICS - December 1, 2022 Category: Pediatrics Source Type: research

Maternal high-fat diet increases airway sensory innervation and reflex bronchoconstriction in adult offspring
Children born to obese mothers are prone to develop asthma and airway hyperresponsiveness, but the mechanisms behind this are unclear. Here, we developed a mouse model of diet-induced maternal obesity that recapitulates metabolic abnormalities seen in humans. Despite being fed a regular diet, adult offspring of high-fat diet fed mothers showed increased adiposity, hyperinsulinemia and insulin resistance. Bronchoconstriction induced by inhaled 5-hydroxytriptamine was significantly increased in offspring of high-fat diet vs. regular diet mothers. Increased bronchoconstriction was blocked by vagotomy, demonstrating that airwa...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Calco, G., Alharithi, Y., Phillips, E., Jacoby, D., Fryer, A., Maloyan, A., Nie, Z. Tags: 05.03 - Allergy and immunology Source Type: research