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Total 872 results found since Jan 2013.
Anti-tumor activity of trimethoprim-sulfamethoxazole against melanoma skin cancer through triggering allergic reaction and promoting immunity
This study examined the potential roles of TMP-SMX in melanoma skin cancer using an immunodeficient mouse model. TMP-SMX significantly improved the survival rate and reduced the tumor weight and growth and vascular endothelial growth factor levels in melanoma skin cancer of immunodeficient mice. In the forced swimming test, TMP-SMX significantly reduced immobility time compared to the melanoma skin cancer of immunodeficient mice, indicating improved immunity. TMP-SMX significantly increased infiltration of mast cells and release of allergy-related mediators (IgE, histamine, interleukin (IL)-4, IL-5, IL-13, and IL-33) and i...
Source: International Immunopharmacology - August 3, 2023 Category: Allergy & Immunology Authors: Hee-Yun Kim Ho-Geun Kang Hyung-Min Kim Hyun-Ja Jeong Source Type: research
Doctors have long considered the thymus expendable. But could removing it be fatal?
The thymus, a butterfly-shaped organ that sits between our collarbones, has never seemed like a particularly useful appendage—at least in adults. During early childhood, it provides a place for T cells (the T stands for thymus) to mature into immune cells that attack invaders. But during adolescence the organ begins to shrink and mostly stops producing these cells. By adulthood, it’s assumed to be so useless that cardiac surgeons will occasionally remove it just to get easier access to the heart.
But researchers have recently started to question that assumption, and a study published today in
The New England Jo...
Source: ScienceNOW - August 2, 2023 Category: Science Source Type: news
An outlook on the target-based molecular mechanism of phytoconstituents as immunomodulators
Phytother Res. 2023 Aug 1. doi: 10.1002/ptr.7969. Online ahead of print.ABSTRACTThe immune system is one of the essential defense mechanisms. Immune system inadequacy increases the risk of infections and cancer diseases, whereas over-activation of the immune system causes allergies or autoimmune disorders. Immunomodulators have been used in the treatment of immune-related diseases. There is growing interest in using herbal medicines as multicomponent agents to modulate the complex immune system in immune-related diseases. Many therapeutic phytochemicals showed immunomodulatory effects by various mechanisms. This mechanism ...
Source: Cell Research - August 2, 2023 Category: Cytology Authors: Gazala Noor None Badruddeen Juber Akhtar Bhuwanendra Singh Mohammad Ahmad Mohammad Irfan Khan Source Type: research
Role of the membrane-spanning 4A gene family in lung adenocarcinoma
In this study, we found that 11 MS4A family genes were upregulated or downregulated in lung adenocarcinoma. Furthermore, we described the genetic variation landscape of the MS4A family in lung adenocarcinoma. Notably, through functional enrichment analysis, we discovered that the MS4A family is involved in the immune response regulatory signaling pathway and the immune response regulatory cell surface receptor signaling pathway. According to the Kaplan–Meier curve, patients with lung adenocarcinoma having poor expression of MS4A2, MS4A7, MS4A14, and MS4A15 had a low overall survival rate. These four prognostic genes are ...
Source: Frontiers in Genetics - July 18, 2023 Category: Genetics & Stem Cells Source Type: research
Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, direct oral penicillin challenge in patients with a low-risk penicillin allergy was noninferior compared with standard-of-care skin testing followed by oral challenge. In patients with a low-risk history, direct oral penicillin challenge is a safe procedure to facilitate the removal of a penicillin allergy label.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04454229.PMID:37459086 | DOI:10.1001/jamainternmed.2023.2986
Source: Cancer Control - July 17, 2023 Category: Cancer & Oncology Authors: Ana Maria Copaescu Sara Vogrin Fiona James Kyra Y L Chua Morgan T Rose Joseph De Luca Jamie Waldron Andrew Awad Jack Godsell Elise Mitri Belinda Lambros Abby Douglas Rabea Youcef Khoudja Ghislaine A C Isabwe Genevieve Genest Michael Fein Cristine Radojici Source Type: research
The First Over-the-Counter Birth Control Pill Gets Official Approval
WASHINGTON (AP) — U.S. officials have approved the first over-the-counter birth control pill, which will let American women and girls buy contraceptive medication from the same aisle as aspirin and eyedrops.
The Food and Drug Administration said Thursday it cleared Perrigo’s once-a-day Opill to be sold without a prescription, making it the first such medication to be moved out from behind the pharmacy counter. The company won’t start shipping the pill until early next year, and there will be no age restrictions on sales.
Hormone-based pills have long been the most common form of birth control in the U.S.,...
Source: TIME: Health - July 13, 2023 Category: Consumer Health News Authors: MATTHEW PERRONE / AP Tags: Uncategorized Equality wire Source Type: news
The Conspirituality of Robert F. Kennedy Jr.
This article has been adapted from Chapter 23 of Conspirituality: How New Age Conspiracy Theories Became a Health Threat by Derek Beres, Matthew Remski, and Julian Walker. Copyright © 2023. Available from PublicAffairs, an imprint of Hachette Book Group, Inc.
Source: TIME: Health - July 5, 2023 Category: Consumer Health News Authors: Derek Beres, Matthew Remski, and Julian Walker Tags: Uncategorized freelance politics Source Type: news
Australian parental perceptions of genomic newborn screening for non-communicable diseases
Discussion: The results from this study will inform future policy for genomic NBS, including expected rate of uptake and interventions that parents would consider employing to prevent the onset of disease.
Source: Frontiers in Genetics - June 26, 2023 Category: Genetics & Stem Cells Source Type: research
'Rare' cancer may mimic allergy symptoms - including mucus running from your nose
Millions of Britons suffer from various allergies, however, supposed symptoms could actually be something more sinister.
Source: Daily Express - Health - June 9, 2023 Category: Consumer Health News Source Type: news
Immunomodulatory Properties of Natural Extracts and Compounds Derived from < em > Bidens pilosa < /em > L.: Literature Review
Pharmaceutics. 2023 May 13;15(5):1491. doi: 10.3390/pharmaceutics15051491.ABSTRACTBidens pilosa L. has been used in different parts of the world mainly to treat diseases associated with immune response disorders, such as autoimmunity, cancer, allergies, and infectious diseases. The medicinal properties of this plant are attributed to its chemical components. Nevertheless, there is little conclusive evidence that describes the immunomodulatory activity of this plant. In this review, a systematic search was carried out in the PubMed-NLM, EBSCO Host and BVS databases focused on the pre-clinical scientific evidence of the immu...
Source: Cancer Control - May 27, 2023 Category: Cancer & Oncology Authors: Xandy Melissa Rodr íguez-Mesa Leonardo Andres Contreras Bola ños Antonio Mej ía Luis Miguel Pombo Geison Modesti Costa Sandra Paola Santander Gonz ález Source Type: research
Chitinase-like proteins promoting tumorigenesis through disruption of cell polarity < em > via < /em > enlarged endosomal vesicles
DISCUSSION: We find one of the Idgf's members, Idgf3, is transcriptionally induced in a JNK-dependent manner via a positive feedback loop mediated by reactive oxygen species (ROS). Moreover, Idgf3 accumulates in enlarged endosomal vesicles (EnVs) that promote tumor progression by disrupting cytoskeletal organization. The process is mediated via the downstream component, aSpectrin, which localizes to the EnVs. Our data provide new insight into CLP function in tumors and identifies specific targets for tumor control.PMID:37188187 | PMC:PMC10175591 | DOI:10.3389/fonc.2023.1170122
Source: Atherosclerosis - May 15, 2023 Category: Cardiology Authors: Dilan Khalili Martin Kunc Sarah Herbrich Anna M M üller Ulrich Theopold Source Type: research
Antibody-mediated regulation of basophils: emerging views and clinical implications
Trends Immunol. 2023 May 3:S1471-4906(23)00059-5. doi: 10.1016/j.it.2023.04.003. Online ahead of print.ABSTRACTAn increasing number of human diseases, including allergies, infections, inflammation, and cancer, involve roles for basophils. Traditionally viewed as the rarest leukocytes that are present only in the circulation, basophils have recently emerged as important players in systemic as well as tissue-specific immune responses. Their functions are regulated by immunoglobulins (Igs), and this enables basophils to integrate diverse adaptive and innate immunity signals. IgE is well known to regulate basophil responses in...
Source: Trends in Immunology - May 5, 2023 Category: Allergy & Immunology Authors: Kang Chen Yujing Hao Mauricio Guzm án Genxia Li Andrea Cerutti Source Type: research
Chitinase-like proteins promoting tumorigenesis through disruption of cell polarity via enlarged endosomal vesicles
IntroductionChitinase-like proteins (CLPs) are associated with tissue-remodeling and inflammation but also with several disorders, including fibrosis, atherosclerosis, allergies, and cancer. However, CLP’s role in tumors is far from clear. MethodsHere, we utilize Drosophila melanogaster and molecular genetics to investigate the function of CLPs (imaginal disc growth factors; Idgf’s) in RasV12 dysplastic salivary glands. Results and discussionWe find one of the Idgf’s members, Idgf3, is transcriptionally induced in a JNK-dependent manner via a positive feedback loop mediated by reactive oxygen species (ROS). Moreover,...
Source: Frontiers in Oncology - April 28, 2023 Category: Cancer & Oncology Source Type: research
Piperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In participants undergoing open pancreatoduodenectomy, use of piperacillin-tazobactam as perioperative prophylaxis reduced postoperative SSI, pancreatic fistula, and multiple downstream sequelae of SSI. The findings support the use of piperacillin-tazobactam as standard care for open pancreatoduodenectomy.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03269994.PMID:37078771 | DOI:10.1001/jama.2023.5728
Source: Cancer Control - April 20, 2023 Category: Cancer & Oncology Authors: Michael I D'Angelica Ryan J Ellis Jason B Liu Brian C Brajcich Mithat G önen Vanessa M Thompson Mark E Cohen Susan K Seo Emily C Zabor Michele L Babicky David J Bentrem Stephen W Behrman Kimberly A Bertens Scott A Celinski Carlos H F Chan Mary Dillhoff M Source Type: research
Lysophosphatidylinositol Promotes Chemotaxis and Cytokine Synthesis in Mast Cells with Differential Participation of GPR55 and CB2 Receptors
Int J Mol Sci. 2023 Mar 28;24(7):6316. doi: 10.3390/ijms24076316.ABSTRACTMast cells (MCs) are the main participants in the control of immune reactions associated with inflammation, allergies, defense against pathogens, and tumor growth. Bioactive lipids are lipophilic compounds able to modulate MC activation. Here, we explored some of the effects of the bioactive lipid lysophosphatidylinositol (LPI) on MCs. Utilizing murine bone marrow-derived mast cells (BMMCs), we found that LPI did not cause degranulation, but slightly increased FcεRI-dependent β-hexosaminidase release. However, LPI induced strong chemotaxis together ...
Source: Cancer Control - April 13, 2023 Category: Cancer & Oncology Authors: Lizbeth Magnolia Mart ínez-Aguilar Alfredo Ibarra-S ánchez Daniel Jos é Guerrero-Morán Marina Mac ías-Silva Jes ús Omar Muñoz-Bello Alejandro Padilla Marcela Lizano Claudia Gonz ález-Espinosa Source Type: research
