Piperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy: A Randomized Clinical Trial

CONCLUSIONS AND RELEVANCE: In participants undergoing open pancreatoduodenectomy, use of piperacillin-tazobactam as perioperative prophylaxis reduced postoperative SSI, pancreatic fistula, and multiple downstream sequelae of SSI. The findings support the use of piperacillin-tazobactam as standard care for open pancreatoduodenectomy.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03269994.PMID:37078771 | DOI:10.1001/jama.2023.5728

Source: Cancer Control - April 20, 2023 Category: Cancer & Oncology Authors: Michael I D'Angelica Ryan J Ellis Jason B Liu Brian C Brajcich Mithat G önen Vanessa M Thompson Mark E Cohen Susan K Seo Emily C Zabor Michele L Babicky David J Bentrem Stephen W Behrman Kimberly A Bertens Scott A Celinski Carlos H F Chan Mary Dillhoff M Source Type: research