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Total 872 results found since Jan 2013.

Concerns About Compounded Bioidentical Menopausal Hormone Therapy
Cancer J. 2022 May-Jun 01;28(3):241-245. doi: 10.1097/PPO.0000000000000597.ABSTRACTFollowing the release of the Women's Health Initiative data, women began to use compounded bioidentical hormone therapy (cBHT) in the misguided belief of greater safety and efficacy than traditional hormone therapy. New guidelines recommend government-approved hormone therapy for symptomatic healthy menopausal women younger than 60 years or within 10 years of menopause at the time of initiation. For women requesting bioidentical hormones, those similar to the hormones present before menopause, there are many government-approved hormone thera...
Source: Cancer Journal - May 20, 2022 Category: Cancer & Oncology Authors: JoAnn V Pinkerton Source Type: research

Gender-dependent frequency of unconventional T cells in a healthy adult Caucasian population: A combinational study of invariant NKT cells, γδ T cells, and mucosa-associated invariant T cells
This study tested the hypothesis of gender bias in frequency of unconventional T cells. Unconventional T cells exist as minor subsets of T cells in peripheral blood. Despite their low number, they play a crucial role in various immune-mediated diseases such as inflammation, autoimmunity, allergy, and cancer. Gender-based frequency of these cells altogether on large number of healthy individuals are unestablished creating hurdles to manifest association with various immune-mediated pathologic conditions. In this study, we used a multicolor flow cytometric panel to identify iNKT cells, γδ T cells, and MAIT cells altogether...
Source: Journal of Leukocyte Biology - May 19, 2022 Category: Hematology Authors: Parvind Singh Marianna Szaraz-Szeles Zoltan Mezei Sandor Barath Zsuzsanna Hevessy Source Type: research

Concerns About Compounded Bioidentical Menopausal Hormone Therapy
Following the release of the Women's Health Initiative data, women began to use compounded bioidentical hormone therapy (cBHT) in the misguided belief of greater safety and efficacy than traditional hormone therapy. New guidelines recommend government-approved hormone therapy for symptomatic healthy menopausal women younger than 60 years or within 10 years of menopause at the time of initiation. For women requesting bioidentical hormones, those similar to the hormones present before menopause, there are many government-approved hormone therapies with extensive pharmacokinetic, safety, and efficacy data provided with packag...
Source: The Cancer Journal - May 1, 2022 Category: Cancer & Oncology Tags: Review Articles Source Type: research

Unleashing cell-penetrating peptide applications for immunotherapy
Trends Mol Med. 2022 Apr 21:S1471-4914(22)00078-8. doi: 10.1016/j.molmed.2022.03.010. Online ahead of print.ABSTRACTWith the advent of cancer immunotherapy, immunomodulation has emerged as an important strategy for the treatment of various diseases. We review recent advances in clinical trials of cell-penetrating peptide (CPP) applications for immunotherapy and also discuss their challenges and opportunities for preclinical studies in various immune diseases. CPP conjugation to antigenic peptides or proteins can enable efficient antigen uptake and cross-presentation by antigen-presenting cells (APCs), which induce both hum...
Source: Molecular Medicine - April 25, 2022 Category: Molecular Biology Authors: Ja-Hyun Koo Gil-Ran Kim Kyung-Ho Nam Je-Min Choi Source Type: research

Probiotics for the Treatment of Gastric Diseases
Nutr Cancer. 2022 Apr 20:1-7. doi: 10.1080/01635581.2022.2067335. Online ahead of print.ABSTRACTCommon gastric diseases include chronic gastritis, gastric ulcers and gastric cancer. The etiology of gastric diseases is complicated, including genetics, diet, excessive smoking and drinking, environmental factors, and bacterial infections. As live microorganisms, probiotics can confer health benefits to the host. At present, probiotics have been widely used in the preparation of foods, health products, and medicines. Due to their positive effects in improving diarrhea, constipation, alleviating allergies, enhancing immunity, a...
Source: Nutrition and Cancer - April 20, 2022 Category: Cancer & Oncology Authors: Yingying Xing Xinyue Gu Guojing Ruan Simiao Chen Source Type: research