Prevalence, awareness, treatment and control of type 2 diabetes in southeast China: A population‐based study
ConclusionsThe prevalence of type 2 diabetes among residents aged 35 –75 years in southeast China is high, whereas the status of its low awareness, treatment and control is severe, warranting a broad-based global strategy, including greater efforts in earlier screening, and more effective and affordable treatment is essential. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 14, 2024 Category: Endocrinology Authors: Xiangju Hu,
Xin Fang,
Minxia Wu Tags: Original Article Source Type: research
Impact of diabetes on the prognosis of patients with oral and oropharyngeal cancer: A meta ‐analysis
ConclusionsPatients with oral and oropharyngeal cancer might have a poor survival if they have pre-existing diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 11, 2024 Category: Endocrinology Authors: Wei Xu,
Zhi Chen,
Laijian Zhang Tags: ORIGINAL ARTICLE Source Type: research
Postpartum life interventions to prevent type 2 diabetes in women with gestational diabetes: A systematic review and meta ‐analysis
ConclusionOur comprehensive meta-analysis of lifestyle interventions can improve modifiable anthropometric measures in women with gestational diabetes. We need further research to provide more intensive lifestyle intervention, more scientific intervention methods, and to reduce the incidence of type 2 diabetes in patients with gestational diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 10, 2024 Category: Endocrinology Authors: Yu Wang,
Wenjun Wei,
Heming Guo,
Dengmin Wang,
Xueli Wei,
Chunlan Zhang,
Xiaoyan Zhang,
Yun Huang Tags: Original Article Source Type: research
Circulating netrin ‐1 levels are reduced and related to corneal nerve fiber loss in patients with diabetic neuropathy
ConclusionsSerum netrin-1 levels show a progressive decline with increasing severity of small nerve fiber damage in patients with diabetes. Netrin-1 could act as a biomarker for small nerve fiber damage in DN. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 10, 2024 Category: Endocrinology Authors: Asif Mondal,
Chiranjit Bose,
Subhasish Pramanik,
Debasish Dash,
Bidisha Mukherjee,
Rayaz A Malik,
Satinath Mukhopadhyay Tags: Original Article Source Type: research
Mitochondrial ALDH2 improves ß‐cell survival and function against doxorubicin‐induced apoptosis by targeting CK2 signaling
ConclusionsMitochondrial ALDH2 activation could inhibit the progression of doxorubicin induced pancreatic β-cell dysfunction by inhibiting the acid sphingomyelinase induction of ceramide, by regulating the activation of CK2 signaling. Our research lays the foundation of ALDH2 activation as a therapeutic target for the precise treatment of chemotherapy drug induced β-cell dysfunction. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 8, 2024 Category: Endocrinology Authors: Udayakumar Karunakaran,
Eun Yeong Ha,
Suma Elumalai,
Kyu Chang Won,
Jun Sung Moon Tags: Original Article Source Type: research
Internet of things ‐based approach for glycemic control in people with type 2 diabetes: A randomized controlled trial
ConclusionsThe IoT-based approach did not reduce HbA1c in patients with type 2 diabetes. IoT-based intervention using data on the daily glycemic control and HbA1c level may be required to improve glycemic control. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 7, 2024 Category: Endocrinology Authors: Ryotaro Bouchi,
Kazuo Izumi,
Naoki Ishizuka,
Yukari Uemura,
Hiroshi Ohtsu,
Kengo Miyo,
Shigeho Tanaka,
Noriko Satoh ‐Asahara,
Kazuo Hara,
Masato Odawara,
Yoshiki Kusunoki,
Hidenori Koyama,
Takeshi Onoue,
Hiroshi Arima,
Kazuyo Tsushita,
Hi Tags: Clinical Trial Source Type: research
PIONEER REAL Japan: Baseline characteristics of a multicenter, prospective, real ‐world study of oral semaglutide in adults with type 2 diabetes in clinical practice in Japan
ConclusionsPIONEER REAL Japan describes the characteristics of individuals with type 2 diabetes prescribed oral semaglutide. The baseline characteristics provide insights into Japanese individuals with type 2 diabetes prescribed oral semaglutide in clinical practice. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 7, 2024 Category: Endocrinology Authors: Ryo Suzuki,
Hanan Amadid,
Atheline Major ‐Pedersen,
Daisuke Yabe Tags: Original Article Source Type: research
A multicenter, open ‐label, single‐arm trial of the long‐term safety of empagliflozin treatment for refractory diabetes mellitus with insulin resistance (EMPIRE‐02)
ConclusionsEmpagliflozin demonstrated a certain level of safety and efficacy for the treatment of insulin resistance syndrome and lipoatrophic diabetes over 52 weeks, confirming its potential as a therapeutic option. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 5, 2024 Category: Endocrinology Authors: Yushi Hirota,
Yasumasa Kakei,
Junta Imai,
Hideki Katagiri,
Ken Ebihara,
Jun Wada,
Junichi Suzuki,
Tatsuhiko Urakami,
Takashi Omori,
Wataru Ogawa Tags: Original Article Source Type: research
Efficacy and tolerability of oral semaglutide in Japanese patients with type 2 diabetes mellitus: Analysis report from diabetes specialist clinics
ConclusionsOral semaglutide treatment demonstrates efficacy and tolerability for managing type 2 diabetes mellitus in Japan. Significant improvements in metabolic factors induced by oral semaglutide are anticipated, particularly in obese patients. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - May 4, 2024 Category: Endocrinology Authors: Tetsuaki Inokuchi,
Yoshihide Fukumoto,
Gendai Lee,
Yoshifumi Yokomizo,
Kokichi Tanaka,
Michiko Chosa,
Masaru Doi,
Noboru Tamaki,
Seiichi Goto,
Kojiro Ichikawa,
Kazuo Kobayashi Tags: Original Article Source Type: research
Issue Information
(Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 30, 2024 Category: Endocrinology Tags: Issue Information Source Type: research
Glycemic variability is associated with sural nerve conduction velocity in outpatients with type 2 diabetes: Usefulness of a new point‐of‐care device for nerve conduction studies
ConclusionsIn outpatients with type 2 diabetes, multiple CGM-derived GV metrics were significantly associated with SCV obtained by DPNCheck ™. GV may have independent impacts on peripheral nerve function, particularly in patients with well-controlled HbA1c levels. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 30, 2024 Category: Endocrinology Authors: Machiko Morita,
Kentaro Sada,
Shuji Hidaka,
Miki Ogawa,
Hirotaka Shibata Tags: Original Article Source Type: research
Optimizing lipid control in Taiwanese diabetic patients: A collaborative consensus by the Diabetes Association of the Republic of China (Taiwan) and the Taiwanese Association of Diabetes Educators
We present an in-depth analysis of dyslipidemia management strategies for patients with diabetes mellitus in Taiwan. It critically examines the disparity between established guideline recommendations and actual clinical practices, particularly in the context of evolving policies affecting statin prescriptions. The focus is on synthesizing the most recent findings concerning lipid management in patients with diabetes mellitus, with a special emphasis on establishing consensus regarding low-density lipoprotein cholesterol treatment targets. The article culminates in providing comprehensive, evidence-based recommendations tai...
Source: Journal of Diabetes Investigation - April 28, 2024 Category: Endocrinology Authors: Feng ‐Chih Shen,
Chih‐Hsun Chu,
Jung‐Fu Chen,
Chin‐Sung Kuo,
Chih‐Yao Hsu,
Ching‐Han Lin,
Yi‐Jing Sheen,
Sheng‐Chiang Su,
Kai‐Jen Tien,
Chieh‐Hua Lu,
Chun‐Chuan Lee,
Yi‐Sun Yang,
Shih‐Te Tu,
Po‐Tsang Chen,
Ching Tags: Special Research Report Source Type: research
Pancreatic beta ‐cell mass and function and therapeutic implications of using antidiabetic medications in type 2 diabetes
This review article examines the decline in pancreatic β-cell mass and function as central to the pathogenesis of type 1 and advanced type 2 diabetes. It discusses the potential for β-cell regeneration in response to increased insulin demand and evaluates how various antidiabetic medications may affect this process. The therapeutic implications of the se findings for the management and treatment of diabetes are explored, offering new insights into potential interventions. AbstractNowadays, the focus of diabetes treatment has switched from lowering the glucose level to preserving glycemic homeostasis and slowing the disea...
Source: Journal of Diabetes Investigation - April 27, 2024 Category: Endocrinology Authors: Joon Ho Moon,
Hun Jee Choe,
Soo Lim Tags: REVIEW ARTICLE Source Type: research
Possible etiological role of impaired endogenous double strand RNA editing in β‐cells in type 1 diabetes
Proposed mechanisms by which disruption of endogenous dsRNA editing in β-cells leads to type 1 diabetes-like phenotypes in βAdarKO mice. Disruption of endogenous dsRNA editing in β-cells initiates IFN responses, thereby inducing pancreatic islet inflammation and β-cell dysfunction. Hyperglycemia induced by β-cell dysfunction further promotes islet inflammation, li kely via increased dsRNA resulting from increased β-cell workload, thereby producing a vicious cycle. The mechanism by which impairment of dsRNA editing is integrated with autoimmune-mediated pathogenesis of type 1 diabetes remains to be clarified. (Source:...
Source: Journal of Diabetes Investigation - April 26, 2024 Category: Endocrinology Authors: Junta Imai Tags: Commentary Source Type: research
Association between variation in hemoglobin A1c levels and diabetes therapy ‐related quality of life in patients with diabetes
ConclusionsA small variation in HbA1c level was associated with higher total DTR-QOL scores and the scores for each factor. Reducing blood glucose variability is significant when we treat diabetes. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 25, 2024 Category: Endocrinology Authors: Dan Imai,
Emi Ushigome,
Ryosuke Sakai,
Noriyuki Kitagawa,
Masahide Hamaguchi,
Masahiro Yamazaki,
Michiaki Fukui Tags: Original Article Source Type: research
