The epidemiology of cryptorchidism and potential risk factors, including endocrine disrupting chemicals
Congenital cryptorchidism, also known as undescended testis, is the condition where one or both testes are not in place in the scrotum at birth and is one of the most common birth defects in boys. Temporal trends and geographic variation in the prevalence of cryptorchidism from 1% to 9% have been reported in prospective cohort studies. The testes develop in the abdominal cavity and descend to the scrotum in two phases, which should be completed by gestational week 35. Thus, the risk of cryptorchidism is higher in preterm boys. In many cases a spontaneous descent occurs during the first months of life during the surge of go...
Source: Frontiers in Endocrinology - April 3, 2024 Category: Endocrinology Source Type: research
Applying machine-learning models to differentiate benign and malignant thyroid nodules classified as C-TIRADS 4 based on 2D-ultrasound combined with five contrast-enhanced ultrasound key frames
ConclusionsOur model, based on 2D-US and CEUS key frames radiomics features, had good diagnostic efficacy for thyroid nodules, which are classified as C-TIRADS 4. It shows promising potential in assisting less experienced junior radiologists. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - April 3, 2024 Category: Endocrinology Source Type: research
Gestational and neonatal outcomes of women with partial Dunnigan lipodystrophy
ConclusionOur data showed a high frequency of fetal complications in women with FPLD2. However, no instances of infertility or prolonged attempts to conceive have been reported, highlighting the significance of employing effective contraception strategies to plan pregnancies at optimal times for managing metabolic comorbidities. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - April 3, 2024 Category: Endocrinology Source Type: research
Association between AST/ALT ratio and diabetic retinopathy risk in type 2 diabetes: a cross-sectional investigation
ConclusionOur study demonstrates a positive correlation between the AST/ALT ratio and diabetic retinopathy risk in type 2 diabetes, suggesting its potential role in assessing DR risk. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - April 3, 2024 Category: Endocrinology Source Type: research
Heterogeneity and high prevalence of bone manifestations, and bone mineral density in congenital generalized lipodystrophy subtypes 1 and 2
ConclusionBone manifestations are prevalent, heterogeneous, and silent in CGL1 and CGL2. Osteolytic lesions are the most common, followed by osteosclerosis and pseudo-osteopoikilosis. Bone mass is high in most cases. There was no pain complaint related to bone lesions. Thus, systematic assessment of bone manifestations in CGL is essential. Studies are needed to better understand its pathogenesis and clinical consequences. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - April 3, 2024 Category: Endocrinology Source Type: research
Editorial: Endocrine regulation of mineral ions and their relevance to metabolic diseases
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - April 3, 2024 Category: Endocrinology Source Type: research
Corrigendum: The oxidative aging model integrated various risk factors in type 2 diabetes mellitus at system level
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - April 3, 2024 Category: Endocrinology Source Type: research
Thyroid nodule rupture after radiofrequency ablation: case report and literature review
ConclusionNodule rupture is the second most common major complication of RFA. Based on the available evidence, we propose a treatment algorithm for nodule rupture and recommendations for future data collection to address gaps in our understanding of rupture etiology and effective management. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - April 2, 2024 Category: Endocrinology Source Type: research
Anastrozole monotherapy further improves near-adult height after the initial combined treatment with leuprorelin and anastrozole in early-maturing girls with compromised growth prediction: results from the second phase of the GAIL study
ConclusionsIn early-maturing girls with compromised growth potential, the combined treatment with leuprorelin and anastrozole for 2 years or until the age of 11 years resulted in a total gain in height of +9.7 cm when continuing anastrozole monotherapy until the attainment of NAH, as opposed to +7.4 cm if they do not continue with the anastrozole monotherapy and +3.6 cm when treated with leuprorelin alone. Thus, the combined intervention ends at the shortest distance from the target height if continued with anastrozole monotherapy until BA 14 years. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - April 2, 2024 Category: Endocrinology Source Type: research
An ensemble deep learning diagnostic system for determining Clinical Activity Scores in thyroid-associated ophthalmopathy: integrating multi-view multimodal images from anterior segment slit-lamp photographs and facial images
ConclusionThe ensemble multi-view multimodal deep learning system developed in this study can more accurately assess the clinical activity of TAO than traditional methods that solely rely on facial images. This innovative approach is intended to enhance the efficiency of TAO activity assessment, providing a novel means for its comprehensive, early, and precise evaluation. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - April 2, 2024 Category: Endocrinology Source Type: research
Clinical phenotype of a Kallmann syndrome patient with IL17RD and CPEB4 variants
ConclusionBioinformatics analysis shows that the IL17RD protein undergoing Gly701Ser mutation and is speculated to be phosphorylated and modified, thereby disrupting fibroblast growth factor signaling. This study also suggested that the CPEB4 might play a crucial role in the key signaling process affecting olfactory bulb morphogenesis. Overall, the findings of this study broaden the gene expression profile of KS-related pathogenic genes. This offers a new avenue for exploring the pathogenic mechanism of KS and provides valuable insights for precise clinical diagnosis and treatment strategies for this condition. (Source: Fr...
Source: Frontiers in Endocrinology - April 2, 2024 Category: Endocrinology Source Type: research
Turning the tides: achieving rapid and safe glucose control in adolescents with suboptimally controlled type 1 diabetes using advanced hybrid closed loop systems
ConclusionsAHCL systems provide a significant, rapid, and safe improvement in glucose control. This marks a pivotal advancement in technology that primarily benefited those who were already compliant. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - April 2, 2024 Category: Endocrinology Source Type: research
Gestational weight gain and pregnancy outcomes in Chinese women with type 2 diabetes mellitus: evidence from a tertiary hospital in Beijing
ConclusionFor Chinese women with type 2 diabetes, inappropriate gestational weight gain is associated with adverse pregnancy outcomes, and the optimal range of gestational weight gain may differ from the Institute of Medicine recommendations. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - April 2, 2024 Category: Endocrinology Source Type: research
Establishment and validation of a multivariate logistic model for risk factors of thyroid nodules using lasso regression screening
Conclusionsadvanced age, females, overweight individuals, those with impaired fasting glucose, and individuals with dyslipidemia are potential risk factors for thyroid nodule disease. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - April 2, 2024 Category: Endocrinology Source Type: research
Lipoprotein alterations in endocrine disorders - a review of the recent developments in the field
Dyslipidemia is one of the most common disorders worldwide, which, if left untreated, results in a multitude of complications. Thus proper diagnostics, which includes identifying of secondary causes of dyslipidemia is crucial. Endocrine disorders are an important cause of secondary dyslipidemia. This paper aims to review the publications on lipoprotein alterations in endocrine disorders from the past two years and provide an overview of the recent discoveries in this dynamically developing and large field. Significant changes in lipoprotein serum concentrations are present in most endocrinological diseases and can be modif...
Source: Frontiers in Endocrinology - April 2, 2024 Category: Endocrinology Source Type: research
