Plasma mtDNA as a possible contributor to and biomarker of inflammation in rheumatoid arthritis
Neutrophil extracellular trap formation and cell-free DNA (cfDNA) contribute to the inflammation in rheumatoid arthritis (RA), but it is unknown if mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) is more abund... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 7, 2024 Category: Rheumatology Authors: Julia Lehmann, Stavros Giaglis, Diego Kyburz, Douglas Daoudlarian and Ulrich A. Walker Tags: Research Source Type: research
Deficiency of histone deacetylases 3 in macrophage alleviates monosodium urate crystals-induced gouty inflammation in mice
Gout is caused by monosodium urate (MSU) crystals deposition to trigger immune response. A recent study suggested that inhibition of Class I Histone deacetylases (HDACs) can significantly reduce MSU crystals-i... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 6, 2024 Category: Rheumatology Authors: Qi-Bin Yang, Meng-Yun Zhang, Liu Yang, Jie Wang, Qing-Sheng Mi and Jing-Guo Zhou Tags: Research Source Type: research
Rheumatoid arthritis disease activity significantly impacts on the severity of interstitial lung disease
Rheumatoid arthritis (RA) related interstitial lung disease (ILD) impacts on the treatment strategy and its prognosis in patients with RA. However, the relationship between RA disease activity and the severity... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 4, 2024 Category: Rheumatology Authors: Yuhei Ito, Yasutaka Ichikawa, Shuichi Murashima, Hajime Sakuma and Ayako Nakajima Tags: Research Source Type: research
Clinical features of patients with systemic sclerosis positive for anti-SS-A antibody: a cohort study of 156 patients
Anti-SS-A/Ro antibody (anti-SSA), the diagnostic marker of Sj ögren’s syndrome (SS), is often detected in systemic sclerosis (SSc). Some patients are diagnosed with SSc/SS overlap syndromes, while there are ant... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 3, 2024 Category: Rheumatology Authors: Tomoya Watanabe, Yasushi Ototake, Asami Akita, Mao Suzuki, Miwa Kanaoka, Jun Tamura, Yusuke Saigusa and Yukie Yamaguchi Tags: Research Source Type: research
Anti-CX3CL1 (fractalkine) monoclonal antibody attenuates lung and skin fibrosis in sclerodermatous graft-versus-host disease mouse model
Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular injury and inflammation, followed by excessive fibrosis of the skin and other internal organs, including the lungs. CX3CL1 (fractalki... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 3, 2024 Category: Rheumatology Authors: Takumi Hasegawa, Akira Utsunomiya, Takenao Chino, Hiroshi Kasamatsu, Tomomi Shimizu, Takashi Matsushita, Takashi Obara, Naoto Ishii, Hideaki Ogasawara, Wataru Ikeda, Toshio Imai, Noritaka Oyama and Minoru Hasegawa Tags: Research Source Type: research
Sex-specific disparities in disease activity scores among patients with axial spondyloarthritis and their implications for evaluating the response to tumor necrosis factor alpha inhibitor therapy
We aimed to investigate whether there are sex differences in disease activity measures among patients with axial spondyloarthritis (axSpA) and to determine any potential impact on the assessment of treatment r... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 25, 2024 Category: Rheumatology Authors: Seulkee Lee, Seonyoung Kang, Hyungjin Kim, Jaejoon Lee, Min-Ji Kim and Hoon-Suk Cha Tags: Research Source Type: research
Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model
To characterize aspects of triiodothyronine (T3) induced chondrocyte terminal maturation within the molecular osteoarthritis pathophysiology using the previously established T3 human ex vivo osteochondral explant... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 25, 2024 Category: Rheumatology Authors: N. M. Korthagen, E. Houtman, I. Boone, R. Coutinho de Almeida, K. Sivasubramaniyan, R. Mahdad, R. G. H. H Nelissen, Y. F. M. Ramos, M. A Tessari and I. Meulenbelt Tags: Research Source Type: research
Retraction Note: Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4+CCR6+ Th/Treg cell subset imbalance in ankylosing spondylitis
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 19, 2024 Category: Rheumatology Authors: Yanfeng Wu, Mingliang Ren, Rui Yang, Xinjun Liang, Yuanchen Ma, Yong Tang, Lin Huang, Jichao Ye, Keng Chen, Peng Wang and Huiyong Shen Tags: Retraction Note Source Type: research
Long-term effects of abatacept on atherosclerosis and arthritis in older vs. younger patients with rheumatoid arthritis: 3-year results of a prospective, multicenter, observational study
We aimed to reveal the effect of abatacept (ABT) on atherosclerosis in rheumatoid arthritis (RA) patients, 3-year efficacy for arthritis, and safety in a population of older vs. younger patients. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 17, 2024 Category: Rheumatology Authors: Zento Yamada, Sei Muraoka, Mai Kawazoe, Wataru Hirose, Hajime Kono, Shinsuke Yasuda, Takahiko Sugihara and Toshihiro Nanki Tags: Research Source Type: research
Osteoarthritis and hypertension: observational and Mendelian randomization analyses
The association between osteoarthritis (OA) and hypertension is a subject of ongoing debate in observational research, and the underlying causal relationship between them remains elusive. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 17, 2024 Category: Rheumatology Authors: Zhi-Jie Yang, Yuan Liu, Yan-Li Liu, Bin Qi, Xin Yuan, Wan-Xin Shi and Liu Miao Tags: Research Source Type: research
Integrative analysis of single-cell and bulk transcriptome data reveal the significant role of macrophages in lupus nephritis
We attempted to identify abnormal immune cell components and signaling pathways in lupus nephritis (LN) and to identify potential therapeutic targets. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 12, 2024 Category: Rheumatology Authors: Shuping Wei, Haiyun Shen, Yidan Zhang, Chunrui Liu, Shoushan Li, Jing Yao, Zhibin Jin and Hongliang Yu Tags: Research Source Type: research
Deregulation in adult IgA vasculitis skin as the basis for the discovery of novel serum biomarkers
Immunoglobulin A vasculitis (IgAV) in adults has a variable disease course, with patients often developing gastrointestinal and renal involvement and thus contributing to higher mortality. Due to understudied ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 12, 2024 Category: Rheumatology Authors: Matija Baj želj, Matjaž Hladnik, Rok Blagus, Vesna Jurčić, Ana Markež, Tanya Deniz Toluay, Snežna Sodin-Šemrl, Alojzija Hočevar and Katja Lakota Tags: Research Source Type: research
Urate-lowering therapy, serum urate, inflammatory biomarkers, and renal function in patients with gout following pegloticase discontinuation
We examined ULT use, serum urate (SU), inflammatory biomarkers, and renal function f... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 12, 2024 Category: Rheumatology Authors: Emily E. Holladay, Amy S. Mudano, Fenglong Xie, Jingyi Zhang, Ted R. Mikuls, Brian LaMoreaux, Lissa Padnick-Silver and Jeffrey R. Curtis Tags: Research Source Type: research
Correction: Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 10, 2024 Category: Rheumatology Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere and Maurizio Cutolo Tags: Correction Source Type: research
Anxiety and depression symptoms in adolescents and young adults with juvenile idiopathic arthritis: results of an outpatient screening
Previous studies have shown that growing up with rheumatic conditions can fuel dissatisfaction and psychological distress, which in turn affects disease self-management and treatment adherence. Primary objecti... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 10, 2024 Category: Rheumatology Authors: Florian Milatz, Jens Klotsche, Martina Niewerth, Claudia Sengler, Daniel Windschall, Tilmann Kallinich, Frank Dressler, Ralf Trauzeddel, Reinhard W. Holl, Ivan Foeldvari, Normi Br ück, Svenja Temming, Toni Hospach, Petra Warschburger, Rainer Berendes, Ga Tags: Research Source Type: research
