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Drug: Estradiol

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Total 6429 results found since Jan 2013.

Liquid phase extraction of nanosized biologically active estrogenic pollutants by using an efficient adsorbent
Publication date: 15 September 2018Source: Journal of Molecular Liquids, Volume 266Author(s): Roohollah Hafizi, Ramezan Ali Taheri, Hamid MoghimiAbstractDangerous nanosized micropollutants and estrogenic hormones which might severely affect the environment are more found in water effluents, recently, and detection of them is of high importance. As the result, reliable and inexpensive absorptive extraction and removal applications are favored. As the second most abundant biomolecule on earth, a lignocellulosic material can be a potential choice as nanosized adsorbent. In this paper, quantum chemistry techniques are employed...
Source: Journal of Molecular Liquids - July 20, 2018 Category: Molecular Biology Source Type: research

Optimization of medium for in vitro culture of sheep ovarian tissue
Publication date: Available online 22 October 2018Source: Small Ruminant ResearchAuthor(s): A. Seisenbayeva, V. Isachenko, Y. Assanova, X.X. Du, D.Y. Toishybek, Y.M. ToishibekovAbstractCreation of genetic cryobanks is a way of preserving animal genetic materials. The gene bank can be used actively for increasing populations as well as minimization of interrelated crossing. One of the ways of preserving animal genetic material is ovarian tissue cryopreservation. After cryopreservation and storage, part of the ovarian tissue can be thawed and cultured in vitro in order to check a quality of follicles and stromal cells. The v...
Source: Small Ruminant Research - October 23, 2018 Category: Zoology Source Type: research

What do we know and what we would like to know about drone homogenate
ConclusionsThis paper presents the most important information on the use of drone brood in folk medicine. The studies carried out with the use of animals and humans have shown that the drone brood has an adjuvant effect that improves the efficiency of the organism. Due to its high content of amino acids and proteins, it is used as a tonic and adaptogenic agent. The presence of sex hormones in the homogenate allows its use as a potency raising agent and equalizing the hormonal system in people of both sexes.Graphical abstract
Source: Journal of Ethnopharmacology - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Interventions for emergency contraception.
CONCLUSIONS: Levonorgestrel and mid-dose mifepristone (25 mg to 50 mg) were more effective than Yuzpe regimen. Both mid-dose (25 mg to 50 mg) and low-dose mifepristone(less than 25 mg) were probably more effective than levonorgestrel (1.5 mg). Mifepristone low dose (less than 25 mg) was less effective than mid-dose mifepristone. UPA may be more effective than levonorgestrel.Levonorgestrel users had fewer side effects than Yuzpe users, and appeared to be more likely to have a menstrual return before the expected date. UPA users were probably more likely to have a menstrual return after the expected date. Menstrual delay was...
Source: Cochrane Database of Systematic Reviews - January 20, 2019 Category: General Medicine Authors: Shen J, Che Y, Showell E, Chen K, Cheng L Tags: Cochrane Database Syst Rev Source Type: research

Summary of Torsades de Pointes (TdP) Reports Associated with Intravenous Drug Formulations Containing the Preservative Chlorobutanol
ConclusionThe pharmacologic profile of chlorobutanol (synergistic IKR block) and its association with reports of TdP and QT prolongation suggest the need for a full evaluation of its cardiac safety when used as a preservative in IV drug and vitamin formulations.
Source: Drug Safety - March 18, 2019 Category: Drugs & Pharmacology Source Type: research

Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders
Marcia H. Ratner, Vidhya Kumaresan and David H. Farb* Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric disorders; however, the basic underlying mechanisms of memory and altered states of circuitry function associated with disorders of memory remain a vast unexplored territory. The initial discovery of endogenous neurosteroids triggered a quest to elucidate their role as neuromodulators in normal and diseased brain functio...
Source: Frontiers in Endocrinology - April 8, 2019 Category: Endocrinology Source Type: research

Cardiac arrhythmias secondary to hormone therapy in trans women.
Authors: Wamboldt R, Haseeb S, Waddington A, Baranchuk A Abstract INTRODUCTION: With greater social acceptance and the evolution of transgender medicine as a specialty, more trans women are seeking hormone therapy (HT). Several studies have identified an increase in cardiovascular disease in trans women, however no studies have investigated the incidence of arrhythmias. Using two cases from the authors' clinic as examples, we propose that hormone therapy in trans women may increase the risk of cardiac arrhythmias. Areas covered: A literature search of sex hormones and cardiac arrhythmias was conducted. Using sex ho...
Source: Expert Review of Cardiovascular Therapy - April 17, 2019 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

The Current Evidence on the Association Between the Urinary Microbiome and Urinary Incontinence in Women
This study also found that Proteus DNA, a genus with many uropathogenic species (Drzewiecka, 2016), was more prevalent in women with OAB compared to asymptomatic controls (Curtiss et al., 2017). IC A recent study by Abernethy et al. suggested that the microbiome may play a role in IC (Abernethy et al., 2017). In this study, 16S rRNA analysis determined the microbiome of catheterized urine from women (n = 40) with IC was not dominated by a single genus and was less likely to contain Lactobacillus compared to asymptomatic women. Abernethy et al. also showed that L. acidophilus was associated with less severe scores on the ...
Source: Frontiers in cellular and infection microbiology - April 30, 2019 Category: Microbiology Source Type: research

Modeling Streptococcus pyogenes Pharyngeal Colonization in the Mouse
In conclusion, the mouse pharyngeal colonization model is an affordable and accessible experimental system that allows a broader group of research groups to test the importance of their findings in an in vivo model. There is a great deal of overlap between the bacterial and immune factors found to be important in human and murine pharyngeal colonization. Although MHC-II humanized mice could prove useful in answering certain questions, the use of inbred mouse lines appears to be sufficient for evaluation of most questions, both related to bacterial factors and the host immune response. However, when promising treatments or ...
Source: Frontiers in cellular and infection microbiology - May 1, 2019 Category: Microbiology Source Type: research

EAA clinical practice guidelines —gynecomastia evaluation and management
ConclusionsThe purpose of GM assessment should be the detection of underlying pathological conditions, reversible causes (administration/abuse of aggravating substances), and the discrimination from other breast lumps, particularly breast cancer. Assessment should comprise a thorough medical history and physical examination of the breast and genitalia (including testicular ultrasound). A set of laboratory investigations may integrate the evaluation: testosterone (T), estradiol (E2), sex hormone ‐binding globulin (SHBG), luteinizing hormone (LH), follicular stimulating hormone (FSH), thyroid stimulating hormone (TSH), pro...
Source: Andrology - May 15, 2019 Category: Urology & Nephrology Authors: G. A. Kanakis, L. Nordkap, A. K. Bang, A. E. Calogero, G. B ártfai, G. Corona, G. Forti, J. Toppari, D. G. Goulis, N. Jørgensen Tags: Original Article Source Type: research

Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications. Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/ Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Effectiveness of hormones in postmenopausal pelvic floor dysfunction —International Urogynecology Association research and development—committee opinion
ConclusionsIn summary, local estrogen seems to be safe and effective in the treatment of VVS and can also improve urinary symptoms in postmenopausal patients with UI, but most of these recommendations correspond to evidence level 2C. The evidence in POP is still scarce but not in favor of benefit. Finally, the duration of local estrogen treatment (LET), optimal dosage, long-term effects and cost-effectiveness compared with current practice are still unknown.
Source: International Urogynecology Journal - August 6, 2019 Category: OBGYN Source Type: research

Add-on effect of Guizhi Fuling formula to mifepristone for endometriosis: A meta-analysis of randomized controlled trials
Conclusion: GZFL as adjuvant therapy to mifepristone appears to have additional benefits in preventing recurrence of endometriosis and improving pregnancy among women with endometriosis. However, these conclusions should be interpreted with caution due to the methodological flaws of the included trials.
Source: Medicine - August 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Long responders to estramustine monophosphate. Report of two cases and literature review.
CONCLUSIONS: We recognize that these clinical cases do not translate that estramustine acetate is a first line treatment for patients with CRPC. Nevertheless, they translate the heterogeneity of CRPC. It would be interesting to investigate the combination of new agents with estramustine acetate as well as the search of biomarkers that enable selection of candidates who could respond to estramustine acetate. PMID: 31475684 [PubMed - in process]
Source: Archivos Espanoles de Urologia - September 3, 2019 Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

Embryo transfer strategy and therapeutic options in infertile patients with thin endometrium: a systematic review
The objective of this systematic review was to investigate all available interventions to improve endometrial thickness (EMT) in women with history of thin endometrium undergoing fresh or frozen-thawed embryo transfers (ET). We performed a comprehensive search of relevant studies from January 1978 to February 2018. The different strategies were categorized as hormonal, vascular, and growth factor approaches and specifically analyzed according to the type of ET. Thirty-one studies were included. Overall, quality of the evidence ranged from very low to moderate, with only few randomized controlled trials that support the use...
Source: Journal of Assisted Reproduction and Genetics - September 8, 2019 Category: Reproduction Medicine Source Type: research