Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders

Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders Marcia H. Ratner, Vidhya Kumaresan and David H. Farb* Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric disorders; however, the basic underlying mechanisms of memory and altered states of circuitry function associated with disorders of memory remain a vast unexplored territory. The initial discovery of endogenous neurosteroids triggered a quest to elucidate their role as neuromodulators in normal and diseased brain function. In this review, based on the perspective of our own research, the advances leading to the discovery of positive and negative neurosteroid allosteric modulators of GABA type-A (GABAA), NMDA, and non-NMDA type glutamate receptors are brought together in a historical and conceptual framework. We extend the analysis toward a state-of-the art view of how neurosteroid modulation of neural circuitry function may affect memory and memory deficits. By aggregating the results from multiple laboratories using both animal models for disease and human clinical research on neuropsychiatric and age-related neurodegenerative disorders, elements of a circuitry level view begins to emerge. Lastly, the effects of both endogenously active and exogenously administered neurosteroids on neural networks acro...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research

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Authors: Joseph CL, Mahajan P, Buzzelli-Stokes S, Jacobsen G, Johnson DA, Duffy E, Williams R, Suzanne H, Zoratti E, Ownby DR, Johnson CC, Lu M Abstract The recruitment setting plays a key role in the evaluation of behavioral interventions. We evaluated a behavioral intervention for urban adolescents with asthma in three randomized trials conducted separately in three different settings over the course of 8 years. We hypothesized that characteristics of trial participants recruited from the ED and clinic settings would be significantly different from that of youth participating in the school-based trials. The inter...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
In this study, organic thin films were formed on the Al films, and their surface plasmon resonance (SPR) wavelengths were measured by our original attenuated total reflectance spectroscopic system. With an increase in the organic film thickness, the SPR wavelength shifted to longer wavelengths. The minimum detection thickness of the organic overlayer reached 2 nm for three Al films under different conditions (i.e., different Al thickness and oxidation effects), and the spectra were reproduced by simulations based on the Fresnel equations. These results showed the practical advantage of the Al-based SPR sensor withou...
Source: Sensors and Actuators A: Physical - Category: Physics Source Type: research
Publication date: Available online 9 November 2019Source: Radiation Physics and ChemistryAuthor(s): Farahani Somayeh, Nader Riyahi Alam, Haghgoo Soheila, Shirazi Alireza, Geraily Ghazale, Gorji Ensiye, Kavousi NasibehAbstractOvercoming the tumor radioresistance along with protecting the adjacent normal tissues is considered as the ultimate goal of the radiation therapy. To achieve this goal, extensive studies have demonstrated the radiosensitization potential of the gold nanoparticles (AuNPs) during treatment with low-energy ionizing radiation due to their high-photoelectric absorption coefficient. Compared to the AuNPs, t...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
CONCLUSION: Dietary CQ10-supplementation was associated with demonstrable benefits in CPZ-induced Parkinsonism-like changes in mice. PMID: 31702498 [PubMed - as supplied by publisher]
Source: Current Aging Science - Category: Geriatrics Tags: Curr Aging Sci Source Type: research
ConclusionThe biochemical composition and biodistribution analysis using FTIRM have been useful for comparing cultured chondrocytes and in situ chondrocytes.
Source: Biotechnology Reports - Category: Biotechnology Source Type: research
Publication date: Available online 9 November 2019Source: Journal of Molecular StructureAuthor(s): Varsha Jain, Golam Mohiuddin, Santanu Kumar PalAbstractHerein, we are reporting a new series of three-ring based polar bent-core molecules with 2-chloro-3-nitrobenzoic acid as the central core, halogen moiety at one terminal and octadecyloxy chain at another terminal. The compounds 10b, 10c, and 10d were shown to exhibit the orthogonal smectic phase during cooling the samples from the isotropic liquid. The mesomorphic behavior was characterized by polarizing optical microscope, differential scanning calorimetry, and small and...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 9 November 2019Source: Life SciencesAuthor(s): Jia-Wan Wang, Zi-Yi Xue, An-Shi WuAbstractAimsThe cardioprotective effects of preconditioning against ischemia-reperfusion (I/R) injury depend on the structural integrity of membrane caveolae and signaling through G protein-coupled receptors (GPCRs). However, the mechanisms underlying opioid preconditioning are not fully understood. Here, we examined whether caveolins transmitted opioid-GPCR signals to the mitochondria to mediate cardioprotection.Main methodsMice were treated with pertussis toxin (PTX) or saline. Thirty-six hours later, mice ...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 9 November 2019Source: Plant Physiology and BiochemistryAuthor(s): Fatma Pehlivan KarakasAbstractGoji berry (Lycium barbarum L.) is a fruit that has many beneficial effects (such as antidiabetic, antioxidant, anticancer, antidepressant, and immunomodulatory) on human health because of several dietary constituents such as phenolics, vitamins, carotenoids, and polysaccharides. In order to develop in vitro culture protocols for callus induction and plant regeneration from different explants of Goji plants and to compare the phenolic composition in calli of different origin, various combinati...
Source: Plant Physiology and Biochemistry - Category: Biochemistry Source Type: research
This study demonstrates that significant perturbation of tween20:cholesterol(1:1) niosome membrane takes place even at premicellar concentration of bile salts. Here, 1-naphthol (1-NpOH), a known and sensitive excited state proton transfer (ESPT) probe, was used to understand the nature of perturbation of the membrane in an unbuffered medium. The significant decrease in 1-NpOH fluorescence intensity in niosome-bile salt mixed system at both lower (10 °C) and higher (50 °C) temperatures indicates the bile salts [sodium cholate (NaC) and sodium deoxycholate (NaDC)] induce perturbation of niosome membranes. Variati...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
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Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
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