Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders
Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders Marcia H. Ratner, Vidhya Kumaresan and David H. Farb* Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric disorders; however, the basic underlying mechanisms of memory and altered states of circuitry function associated with disorders of memory remain a vast unexplored territory. The initial discovery of endogenous neurosteroids triggered a quest to elucidate their role as neuromodulators in normal and diseased brain function. In this review, based on the perspective of our own research, the advances leading to the discovery of positive and negative neurosteroid allosteric modulators of GABA type-A (GABAA), NMDA, and non-NMDA type glutamate receptors are brought together in a historical and conceptual framework. We extend the analysis toward a state-of-the art view of how neurosteroid modulation of neural circuitry function may affect memory and memory deficits. By aggregating the results from multiple laboratories using both animal models for disease and human clinical research on neuropsychiatric and age-related neurodegenerative disorders, elements of a circuitry level view begins to emerge. Lastly, the effects of both endogenously active and exogenously administered neurosteroids on neural networks acro...
Conclusions: The bibliometric analysis allowed to objectively record the productivity and visibility of the Regional System for Vaccines for Streptococcus pneumoniae in the Region. PMID: 32774349 [PubMed]
Authors: Marín-Sánchez A Abstract The basic clinical characteristics of the first 100 fatal cases from COVID-19 in Colombia were analyzed based on reports from the National Institute of Health (INS) since the beginning of the pandemic. Since the INS records do not include clinical variables of comorbidity in the total number of cases reported as positive, but only in patients with fatal outcome, comorbidities, age and sex available in the daily INS reports were reviewed. Their frequency was identified and mortality risk behavior for the analyzed variables was established and compared with the behavior...
Authors: Sola A, Rodríguez S, Cardetti M, Dávila C Abstract Objective: To evaluate and report the clinical characteristics and outcomes of SARS-CoV-2 infection in pregnant women and newborns in Latin America. Methods: Descriptive study based on the prospective report of the units of the Ibero-American Society of Neonatology Network. Results: Of 86 pregnant women with COVID-19 confirmed by RT-PCR in seven countries (6 from Latin America, and Equatorial Guinea) 68% (59) were asymptomatic. Of 32% of symptomatic women, 89% (24) had mild symptoms and 3.5% (3) had severe respiratory symptoms. No wom...
Publication date: 1 December 2020Source: Carbohydrate Polymers, Volume 249Author(s): Younghan Song, Jin Young Seo, Hyungsup Kim, Kyung-Youl Baek
Publication date: Available online 11 August 2020Source: Carbohydrate PolymersAuthor(s): Dongdong Li, Xuan Gao, Xuechun Huang, Pingle Liu, Wei Xiong, Shengtao Wu, Fang Hao, He’an Luo
Publication date: September 2020Source: Biomedical Signal Processing and Control, Volume 62Author(s): Silvia Malavasi, Alessandro Bevilacqua, Giampaolo Gavelli, Domenico Barone
Publication date: September 2020Source: Biomedical Signal Processing and Control, Volume 62Author(s): Stephanos Leandrou, Demetris Lamnisos, Panicos A. Kyriacou, Stephanie Constanti, Constantinos S. Pattichis, for the Alzheimer's Disease Neuroimaging Initiative
CONCLUSIONS: Future initiatives to engage preconception women should span the social-ecological model of health and consider women's personal preferences for accessible and tailored preconception health information and support at individual, interpersonal, community and organisational levels, as well as in the broader environment. SO WHAT?: This research provides guidance to those in health promotion when planning future initiatives to promote and protect women's preconception health. PMID: 32780533 [PubMed - as supplied by publisher]
CONCLUSION: The healthcare providers and policymakers need to be involved in recognising iTaukei community culture and appreciate traditional methods to promote equitable community participation in decision-making for health promotion. SO WHAT?: Community-wide lifestyle interventions, conceptual approaches based on communal perceptions of the problem at hand can also be the basis for future research on identifying socio-cultural factors, for example, the community and family support that can help shape behaviours. PMID: 32761937 [PubMed - as supplied by publisher]
CONCLUSION: This study contributes new insights and depth of understanding about how the empowerment programme can strengthen the process of individual capacity in an effort to mobilise social change for the betterment of the whole community, particularly among indigenous Pasifika population groups. SO WHAT?: Developing empowerment principles will enable others to consider 'how apply' empowerment more practically when working with young people, and not use it flippantly with no real action-oriented outcome. PMID: 32755045 [PubMed - as supplied by publisher]
More News: Acetic Acid | Alzheimer's | Anesthesia | Anesthesiology | Anxiety | Boston University | Brain | Caffeine | Cerebellum | Chemistry | Child Development | Children | Chloride | Cholesterol | Clinical Trials | Dementia | Depression | Dialysis | Drugs & Pharmacology | Eating Disorders & Weight Management | Employment | Endocrinology | Epilepsy | Estradiol | History of Medicine | Hormones | Hyperactivity | Laboratory Medicine | Learning | Low Testosterone | Men | Menopause | Mitochondria | Mitochondrial Disease | Nanotechnology | Neurology | Neuroscience | Obesity | Organic | Orthopaedics | Ovaries | Pancreas | Perfusion | Perinatology & Neonatology | PET Scan | Polycystic Ovary Syndrome | Post Traumatic Stress Disorder | Pregnancy | Propecia | Schizophrenia | Science | Sleep Disorders | Sleep Medicine | Study | Training | Translocation | Universities & Medical Training | USA Health | Women