Summary of Torsades de Pointes (TdP) Reports Associated with Intravenous Drug Formulations Containing the Preservative Chlorobutanol

ConclusionThe pharmacologic profile of chlorobutanol (synergistic IKR block) and its association with reports of TdP and QT prolongation suggest the need for a full evaluation of its cardiac safety when used as a preservative in IV drug and vitamin formulations.
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 17 February 2020Source: Journal of Physics and Chemistry of SolidsAuthor(s): Laurens T. de Haan, Eser M. Akinoglu, Guofu ZhouAbstractA device consisting of a multidomain liquid crystal polymer network sandwiched between a continuous electrode and a perforated silver electrode shows strong surface deformations upon application of an electric field between the electrodes. Here, a new method is presented for the preparation of such a device, in which a silver film with circular holes of a well-controlled diameter was made by evaporating silver onto a monolayer of polystyrene spheres. Due to ...
Source: Journal of Physics and Chemistry of Solids - Category: Physics Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC00357C, CommunicationWei Xiong, Jianqiao Zhang, Yi Xiao, Youhuan Zhu, Zhenyu Wang, Zhou-Guang Lu A new kind of oxygen-rich carbon microspheres with nanoflakes-interlaced architecture has been successfully prepared by a facile surfactant-assisted precipitation polymerization method. This hierarchical infrastructure can efficiently buffer the volume change... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
VITAMIN D is essential for several reasons, including maintaining healthy bones and teeth. It may also protect against a range of diseases and conditions. Lacking in the vitamin could create a worrying sign that is often overlooked. What is it?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Source: Clinical Epidemiology - Category: Epidemiology Tags: Clinical Epidemiology Source Type: research
The traditional view of ventricular excitation and conduction is an all-or-nothing response mediated by a regenerative activation of the inward sodium channel, which gives rise to an essentially constant conduction velocity (CV). However, whereas there is no obvious biological need to tune-up ventricular conduction, the principal molecular components determining CV, such as sodium channels, inward-rectifier potassium channels, and gap junctional channels, are known targets of the “stress” protein kinases PKA and calcium/calmodulin dependent protein kinase II (CaMKII), and are thus regulatable by signal pathways...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
We present two cases of a left ventricular diverticulum causing cardiac arrhythmia which led to furth er surgical treatment.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
J. Mater. Chem. A, 2020, Accepted Manuscript DOI: 10.1039/C9TA14226F, PaperXinxin Zhao, Fengjiao Chen, Junqing Liu, Mingren Cheng, Hai Xu, Jianbo Liu, Yunhua Xu Dendrite growth is a major obstacle for the development of potassium metal anode in K-ion batteries, which causes low Coulombic efficiency, poor cycling stability and safety hazards. Herein, we report... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - Category: Chemistry Authors: Source Type: research
J. Mater. Chem. A, 2020, Advance Article DOI: 10.1039/C9TA12422E, PaperYu Liu, Dezhi Yang, Weigang Wang, Kai Hu, Qinghong Huang, Yi Zhang, Yingchun Miao, Lijun Fu, Meng Wu, Yuping Wu K –S battery can be operated at both high and room temperatures (50 and 25 °C) with remarkable electrochemical performance using pyrolyzed selenium disulfide/polyacrylonitrile (SeS2–CPAN) as the positive electrode and a gel polymer as the electrolyte. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC00171F, CommunicationQing Yang, Yi Ding, Guang He Potassium metal anode is very appealing due to the high theoretical capacity (687 mAh g-1), but the violent reactivity and severe dendrite issues hinder its practical development. Here we report... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Condition:   Contraception Interventions:   Drug: Segesterone Acetate and Ethinyl Estradiol;   Other: Tampon Sponsor:   TherapeuticsMD Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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