Modeling Streptococcus pyogenes Pharyngeal Colonization in the Mouse

In conclusion, the mouse pharyngeal colonization model is an affordable and accessible experimental system that allows a broader group of research groups to test the importance of their findings in an in vivo model. There is a great deal of overlap between the bacterial and immune factors found to be important in human and murine pharyngeal colonization. Although MHC-II humanized mice could prove useful in answering certain questions, the use of inbred mouse lines appears to be sufficient for evaluation of most questions, both related to bacterial factors and the host immune response. However, when promising treatments or vaccines against GAS are identified, non-human primate models remain the gold standard and should be utilized to validate all results. Author Contributions AG conducted most of the literature review and initial writing of the text. MF edited and contributed to the expansion of several sections of the review. Funding This work was supported by NIH NIAID 2R01 AI091779-06 (Federle-PI) and NIAID 1F30 AI136359-01A1 (Gogos-PI). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We would like to thank Kate Rahbari, Britta Rued, and Jennifer Chang for reading through the text and providing valuable comments and suggestions. References Alam, F. M., Turner, C. E., Smith, K., Wiles, S., and...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research

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