Modeling Streptococcus pyogenes Pharyngeal Colonization in the Mouse
In conclusion, the mouse pharyngeal colonization model is an affordable and accessible experimental system that allows a broader group of research groups to test the importance of their findings in an in vivo model. There is a great deal of overlap between the bacterial and immune factors found to be important in human and murine pharyngeal colonization. Although MHC-II humanized mice could prove useful in answering certain questions, the use of inbred mouse lines appears to be sufficient for evaluation of most questions, both related to bacterial factors and the host immune response. However, when promising treatments or vaccines against GAS are identified, non-human primate models remain the gold standard and should be utilized to validate all results. Author Contributions AG conducted most of the literature review and initial writing of the text. MF edited and contributed to the expansion of several sections of the review. Funding This work was supported by NIH NIAID 2R01 AI091779-06 (Federle-PI) and NIAID 1F30 AI136359-01A1 (Gogos-PI). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We would like to thank Kate Rahbari, Britta Rued, and Jennifer Chang for reading through the text and providing valuable comments and suggestions. References Alam, F. M., Turner, C. E., Smith, K., Wiles, S., and...
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WHO warns death tollcould be higher than 2 million without concerted action;Madrid braces for lockdown as Spain reaches 716,481 total infections;surge in cases in AthensFigures prompt French and Dutch warnings, and row in SpainUS approaches 7m cases as officials warn surge could comeWhat lessons can Europe learn from Sweden ’s experience?Why dogs might be a Covid tester ’s best friend7.50pmBSTOfficials have stopped a Covid-19 testing study in theUSafter multiple reports that state and federal public health workers were threatened and face racial slurs.The U.S. Centers for Disease Control and Prevention pulled f...
Conclusion: The prevalence of bacterial isolates among presumptive patients suspected to BSIs in Ethiopia remains high. Furthermore, we found a remarkable variation in the pathogen distribution across the study setting. PMID: 32963541 [PubMed]
Authors: Mishra VN, Kumari N, Pathak A, Chaturvedi RK, Gupta AK, Chaurasia RN Abstract An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan City, China, in December 2019. Since then, the outbreak has grown into a global pandemic, and neither a vaccine nor a treatment for the disease, termed coronavirus disease 2019 (COVID-19), is currently available. The slow translational progress in the field of research suggests that a large number of studies are urgently required. In this context, this review explores the impact of bacteriophages on SARS-CoV-2, especially conce...
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