The Current Evidence on the Association Between the Urinary Microbiome and Urinary Incontinence in Women
This study also found that Proteus DNA, a genus with many uropathogenic species (Drzewiecka, 2016), was more prevalent in women with OAB compared to asymptomatic controls (Curtiss et al., 2017). IC A recent study by Abernethy et al. suggested that the microbiome may play a role in IC (Abernethy et al., 2017). In this study, 16S rRNA analysis determined the microbiome of catheterized urine from women (n = 40) with IC was not dominated by a single genus and was less likely to contain Lactobacillus compared to asymptomatic women. Abernethy et al. also showed that L. acidophilus was associated with less severe scores on the IC symptoms index (Abernethy et al., 2017). L. acidophilus is known to alleviate inflammation (Foye et al., 2012; Li et al., 2016) and is marketed as a probiotic. These findings offer additional evidence in support of the importance of certain Lactobacillus species in the healthy bladder milieu. SUI In one study of women undergoing surgery for SUI, urine specimens were collected from UTI-negative patients and analyzed by 16S rRNA gene sequencing. Of the 197 urine samples, 174 were collected by clean-catch, while only 23—by catheterization. Although 86% of samples had detectable bacterial DNA, no associations were found between bacterial diversity and SUI symptoms (Thomas-White et al., 2017). More recently, a study which included catheterized urine from a mix of SUI and pelvic organ prolapse patients (n = 126) showed that two bacterial species; Atopob...
Bayer's finerenone meets primary endpoint in Phase III FIDELIO-DKD renal outcomes study in patients with chronic kidney disease and type 2 diabetesFinerenone significantly reduced the combined primary endpoint of chronic kidney disease progression, kidney failure or kidney death versus placebo when added to standard of care / Finerenone significantly reduced the combined key secondary endpoint of cardiovascular death or non-fatal cardiovascular events / Chronic kidney disease impacts 4 in 10 patients with type 2 diabetes and is a deadly condition that is underrecognized / Finerenone is the first investigational non-steroid...
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