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Infectious Disease: Endemics

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Total 382 results found since Jan 2013.

Non-classical B Cell Memory of Allergic IgE Responses
Sean P. Saunders1, Erica G. M. Ma1,2, Carlos J. Aranda1 and Maria A. Curotto de Lafaille1,3* 1Division of Pulmonary, Critical Care and Sleep Medicine, Laboratory of Allergy and Inflammation, Department of Medicine, New York University, New York, NY, United States 2Sackler Institute of Graduate Biomedical Sciences, New York University, New York, NY, United States 3Department of Cell Biology, New York University School of Medicine, New York, NY, United States The long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma ce...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

Expanding Research Capacity in Sub-Saharan Africa Through Informatics, Bioinformatics, and Data Science Training Programs in Mali
Conclusion Bioinformatics and data science training programs in developing countries necessitate incremental and collaborative strategies for their feasible and sustainable development. The progress described here covered decades of collaborative efforts centered on training and research on computationally intensive topics. These efforts laid the groundwork and platforms conducive for hosting a bioinformatics and data science training program in Mali. Training programs are perhaps best facilitated through Africa’s university systems as they are perhaps best positioned to maintain core resources during lapses in sho...
Source: Frontiers in Genetics - April 11, 2019 Category: Genetics & Stem Cells Source Type: research

Pollen Serum Specific IgE Sensitization in Respiratory Allergic Patients in Jakarta, Indonesia.
CONCLUSION: although most pollens tested are not originated from native plants to Indonesia, a small number of patients showed specific IgE-sensitizations. Allergic persons planning to travel to the endemic areas of the relevant pollen should be advised. A panel of pollen allergens from local plants is highly desired. PMID: 29093235 [PubMed - in process]
Source: Acta medica Indonesiana - November 4, 2017 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Reactivity of IgE to the allergen hyaluronidase from Polybia paulista (Hymenoptera, Vespidae) venom.
Abstract To date, there are no allergenic extracts or components available in Brazil to diagnosis and treatment of patients with venom allergy from social wasp (Vespidae Family; Polistinae Subfamily) despite of the great number of existing species. We evaluated the immunogenic potential of the Hyal recombinant protein (Pp-Hyal-rec) which was expressed in an insoluble form in comparison with the allergenic native protein (Pp-Hyal-nat) for recognition of immunoglobulin E (IgE) in the serum of allergic patients to venom of the endemic social wasp Polybia paulista from São Paulo State, Brazil. Hyal cDNA from the veno...
Source: Toxicon - March 1, 2014 Category: Toxicology Authors: Jacomini DL, Moreira SM, Pereira FD, de Lima Zollner R, Brochetto Braga MR Tags: Toxicon Source Type: research

NIAID officials call for continued Zika research
(NIH/National Institute of Allergy and Infectious Diseases) Although cases of Zika virus infection appear to be decreasing, the mosquito-borne virus likely will become endemic in the Americas. Given the serious complications of Zika virus infection, researchers must continue their work to better understand how the virus causes disease and to develop effective vaccines and treatments, according to a new article, by Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Disease (NIAID), and colleague Catharine I. Paules, M.D.
Source: EurekAlert! - Infectious and Emerging Diseases - January 13, 2017 Category: Infectious Diseases Source Type: news

A Bivalent Conjugate Vaccine for Malaria and Typhoid Prophylaxis
Malaria is the single leading cause of mortality, especially among children in the developing world. Typhoid fever, caused by infection withSalmonella typhi, is known to be endemic with malaria and causes its own significant disease burden. Scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have developed a novel bivalent vaccine candidate that may effectively prevent malaria and typhoid. This approach significantly enhances immune response to the Pfs25 Malaria transmission blocking antigen and produces a robust immune response againstSalmonella typhi...
Source: NIH OTT Licensing Opportunities - March 1, 2017 Category: Research Authors: ajoyprabhu3 Source Type: research

NIH funds 7 international Centers of Excellence for malaria research
(NIH/National Institute of Allergy and Infectious Diseases) The National Institute of Allergy and Infectious Diseases (NIAID), part of NIH, today announced approximately $9 million in first-year funding, subject to availability, for seven malaria research centers around the world. The seven-year awards continue NIAID's 2010 program that created the International Centers of Excellence for Malaria Research (ICEMRs) in regions where malaria is endemic. The awards fund new and existing centers that work in 14 countries in Africa, Asia and Latin America.
Source: EurekAlert! - Medicine and Health - April 21, 2017 Category: Global & Universal Source Type: news

Dietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice
Conclusion Altogether, our results indicate that dietary VitD deficiency is able to decrease lesion growth and provide an increase in Th1 response in C57BL/6 and BALB/c mice upon L. (L.) amazonensis infection, although it does not decrease parasite burden in either of the murine models used. Thus, VitD may contribute to host susceptibility to murine tegumentary leishmaniasis. Further studies on the influence of immunonutrition in the leishmaniases are needed to better understand the immunobiology of these diseases. Author Contributions HdMG conceived and designed the experiments. GO-S, DB, MM, JEP, JCP, TR, AdF-M, and L...
Source: Frontiers in cellular and infection microbiology - April 9, 2019 Category: Microbiology Source Type: research

Surface (S) Layer Proteins of Lactobacillus acidophilus Block Virus Infection via DC-SIGN Interaction
We describe the unexpected binding of S-layer to cells devoid of DC-SIGN but also confirm that the presence of DC-SIGN was essential for S-layer’s antiviral activity. S-layer protein exerted its antiviral effect with different kinetics than mannan, a known viral inhibitor that also acts on DC-SIGN (Yu et al., 2017). Together our results suggest that inhibition of viral entry by S-layer occurs via a novel S-layer/DC-SIGN interaction. Materials and Methods Isolation of S-Layer Proteins S-layer proteins were extracted from overnight cultures of L. acidophilus ATCC 4356 cells grown in MRS medium at 37°C by usi...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

The Human Upper Respiratory Tract Epithelium Is Susceptible to Flaviviruses
In this study, we exposed apically well-differentiated human NECs cultured at the ALI to the related flaviviruses ZIKV, JEV, WNV, and Usutu virus (USUV). We selected these viruses due to the recent increasing evidences of potential threat to humans (Cadar et al., 2017; Simonin et al., 2018). We show that NECs are particularly susceptible to JEV and WNV infection and to other flaviviruses included in this study. Infection with each virus led to shedding of infectious virus particles through the apical and basolateral surfaces and triggered host mechanisms at the level of inflammatory and antiviral mediators....
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

The Differentiation in vitro of Human Tonsil B Cells With the Phenotypic and Functional Characteristics of T-bet+ Atypical Memory B Cells in Malaria
This study was conducted in the rural village of Kalifabougou, Mali where intense P. falciparum transmission occurs from June to December each year. Isolation of Tonsil B Cells Tonsils were mechanically disrupted in complete RPMI (RPMI 1640 with L-glutamine supplemented with 10% heat-inactivated FBS, 1 mM sodium pyruvate, 1% MEM nonessential amino acids, 50 μM 2-mercaptoethanol, 100 U/ml penicillin, 100 μg/ml streptomycin, and 25 mM HEPES, pH 7.2–7.5 [all from GIBCO, Invitrogen]) and passed through a 70-μm cell strainer to make a single cell suspension. B cells were then negatively selecte...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research

Study vaccine protects monkeys against four types of hemorrhagic fever viruses
(NIH/National Institute of Allergy and Infectious Diseases) Scientists funded by the National Institutes of Health have developed an investigational vaccine that protected cynomolgus macaques against four types of hemorrhagic fever viruses endemic to overlapping regions in Africa. The University of Texas Medical Branch in Galveston and Profectus BioSciences of New York are developing and testing the candidate quadrivalent VesiculoVax vaccine, with support from NIH's National Institute of Allergy and Infectious Diseases (NIAID) and Redeemer's University in Nigeria.
Source: EurekAlert! - Infectious and Emerging Diseases - November 8, 2019 Category: Infectious Diseases Source Type: news

Safety of yellow fever vaccine administration in confirmed egg-allergic patients.
This study aims to describe the outcomes of yellow fever vaccination in patients with confirmed egg allergy (EA). Methods:A prospective study was conducted from January 2018 to September 2019. EA was diagnosed through positive oral food challenge (OFC), recent history of anaphylaxis following egg contact (anaphylaxis in the last 6 months) or immediate allergic reaction in the last 2 months with positive specific IgE. A skinprick test (SPT) with YFV was performed. If the SPT was negative, an intradermal test (ID) was performed at a 1:100 dilution. If the ID was negative, a full dose of YFV was administered. If the skin pr...
Source: Vaccine - August 19, 2020 Category: Allergy & Immunology Authors: Gerhardt CMB, Castro APBM, Pastorino AC, Dorna MB, Nunes-Santos CJ, Aquilante BP, Miyaji KT, Lopes MH Tags: Vaccine Source Type: research

UCLA-led team gets $8.4 million NIH grant to probe mysteries of Valley Fever
Why do some people infected with Valley Fever develop a potentially fatal form of the disease that ravages their body while most experience only mild symptoms or none at all?A team led by UCLA ’s Dr. Manish Butte has been awarded an $8.4 million grant from the National Institute of Allergy and Infectious Diseases to study this and other questions related to genetic risk factors and immune responses to the disease, which occurs when people breathe in microscopic spores of the fungusCoccidioides that are present in soil.First identified in Argentina in the late 1800s, Valley Fever today is seen in a geographic swath that s...
Source: UCLA Newsroom: Health Sciences - February 15, 2022 Category: Universities & Medical Training Source Type: news

Frequency of allergic reactions in egg allergic patients after receiving the yellow fever vaccine
CONCLUSIONS: YFV did not trigger allergic reactions in EAP without history of egg-anaphylaxis. With further research, safe single-dose vaccination to this population could be considered; however, patients with previous egg-anaphylaxis should be evaluated by an allergist before vaccination.PMID:37422790 | DOI:10.15586/aei.v51i4.850
Source: Allergologia et Immunopathologia - July 9, 2023 Category: Allergy & Immunology Authors: Maria Beatriz Garc ía-Paba Camila Aparicio Mateo Rodr íguez Sergio Moreno Elizabeth Garc ía Source Type: research