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Condition: Autoimmune Disease

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Total 230 results found since Jan 2013.

MicroRNA-20a negatively regulates expression of NLRP3-inflammasome by targeting TXNIP in adjuvant-induced arthritis fibroblast-like synoviocytes
Conclusion Taken together, these results indicate that miR-20a may play a pivotal role in the NLRP3-inflammasome by targeted inhibit TXNIP expression in AA FLSs.
Source: Joint Bone Spine - February 29, 2016 Category: Orthopaedics Source Type: research

Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice
Conclusions/interpretation Epigenetic modification of DNA by methylation in response to immunological stressors may be a mechanism that affects insulin gene expression during the progression of type 1 diabetes.
Source: Diabetologia - April 9, 2016 Category: Endocrinology Source Type: research

Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes
Conclusions Inhibition of HDAC3 in RA FLS largely recapitulates the effects of pan-HDACi in suppressing inflammatory gene expression, including type I IFN production in RA FLS. Our results identify HDAC3 as a potential therapeutic target in the treatment of RA and type I IFN-driven autoimmune diseases.
Source: Annals of the Rheumatic Diseases - December 8, 2016 Category: Rheumatology Authors: Angiolilli, C., Kabala, P. A., Grabiec, A. M., Van Baarsen, I. M., Ferguson, B. S., Garcia, S., Malvar Fernandez, B., McKinsey, T. A., Tak, P. P., Fossati, G., Mascagni, P., Baeten, D. L., Reedquist, K. A. Tags: Open access Basic and translational research Source Type: research

Human Th17 Migration in Three ‐dimensional Collagen Involves p38 MAPK
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - February 15, 2017 Category: Biochemistry Authors: Maleck Kadiri, Mohamed ‐Amine El Azreq, Sofiane Berrazouane, Marc Boisvert, Fawzi Aoudjit Tags: Article Source Type: research

Human CLEC16A regulates autophagy through modulating mTOR activity.
Abstract CLEC16A is genetically linked with multiple autoimmune disorders but its functional relevance in autoimmunity remains obscure. Recent evidence has signposted the emerging role of autophagy in autoimmune disease development. Here, by ectopic expression and siRNA silencing, we show that CLEC16A has an inhibitory role in starvation-induced autophagy in human cells. Combining quantitative proteomics and immunoblotting analyses, we found that CLEC16A likely regulates autophagy by activating mTOR pathway. Overexpression of CLEC16A was found to sensitize cells towards the availability of nutrients, resulting in ...
Source: Experimental Cell Research - February 17, 2017 Category: Cytology Authors: Tam RC, Li MW, Gao YP, Pang YT, Yan S, Ge W, Lau CS, Chan VS Tags: Exp Cell Res Source Type: research

Interleukin-1 receptor associated kinase 1 is a potential therapeutic target of anti-inflammatory therapy for systemic lupus erythematosus
Publication date: July 2017 Source:Molecular Immunology, Volume 87 Author(s): Mingfang Li, Datang Yu, Bing Ni, Fei Hao Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease and currently has no effective therapy. The genome-wide analyses indicate that interleukin-1 receptor associated kinase 1 (IRAK1) is associated with the susceptibility of SLE in humans. In the present study, we identified that IRAK1 was overexpressed and hyper-activated in splenic mononuclear cells from B6.MRL-Faslpr/Nju (B6.lpr) mice and peripheral blood mononuclear cells (PBMCs) from SLE patients. Intraperitoneal treatment w...
Source: Molecular Immunology - April 18, 2017 Category: Allergy & Immunology Source Type: research

Updates on smart polymeric carrier systems for protein delivery.
Authors: El-Sherbiny IM, Khalil IA, Ali IH, Yacoub MH Abstract Smart materials are those materials that are responsive to chemical (organic molecules, chemical agents or specific agents), biochemical (protein, enzymes, growth factors, substrates or ligands), physical (electric field, magnetic field, temperature, pH, ionic strength or radiation) or mechanical (pressure or mechanical stress) signals. These responsive materials interact with the stimuli by changing their properties or conformational structures in a predictable manner. Recently, smart (stimuli-responsive) polymers have been utilized in various applicat...
Source: Drug Development and Industrial Pharmacy - June 8, 2017 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Calcitriol-mediated reduction in IFN- γ output in T cell large granular lymphocytic leukemia requires vitamin D receptor upregulation
Publication date: Available online 20 July 2017 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): M. Paige Kulling, C. Kristine Olson, L. Thomas Olson, E. Cait Hamele, N. Kathryn Carter, J. David Feith, P. Thomas Loughran Constitutively activated STAT1 and elevated IFN-γ are both characteristic of T cell large granular lymphocytic leukemia (T-LGLL), a rare incurable leukemia with clonal expansion of cytotoxic T cells due to defective apoptosis. Interferon gamma (IFN-γ) is an inflammatory cytokine that correlates with worse progression and symptomology in multiple autoimmune diseases and cancers...
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 21, 2017 Category: Biochemistry Source Type: research

Targeting senescent cholangiocytes and activated fibroblasts with Bcl ‐xL inhibitors ameliorates fibrosis in Mdr2‐/‐ mice
Conclusions: Bcl‐xL is a key survival factor in ASF as well as in senescent cholangiocytes. Treatment with the Bcl‐xL‐specific inhibitor A‐1331852 reduces liver fibrosis, possibly by a dual effect on activated fibroblasts and senescent cholangiocytes. This novel mechanism represents an attractive therapeutic strategy in biliary fibrosis. This article is protected by copyright. All rights reserved.
Source: Hepatology - August 12, 2017 Category: Internal Medicine Authors: Anja Moncsek, Mohammed S. Al ‐Suraih, Christy E. Trussoni, Steven P. O'Hara, Patrick L. Splinter, Camille Zuber, Eleonora Patsenker, Piero V. Valli, Christian D. Fingas, Achim Weber, Yi Zhu, Tamar Tchkonia, James L. Kirkland, Gregory J. Gores, Beat Mül Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research

The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells.
Abstract Systemic gamma-aminobutyric acid (GABA) therapy prevents or ameliorates type 1 diabetes (T1D), by suppressing autoimmune responses and stimulating pancreatic beta cells. In beta cells, it increases insulin secretion, prevents apoptosis, and induces regeneration. It is unclear how GABA mediates these effects. We hypothesized that Klotho is involved. It is a multi-functional protein expressed in the kidneys, brain, pancreatic beta cells, other tissues, and is cell-bound or soluble. Klotho knockout mice display accelerated aging, and in humans Klotho circulating levels decline with age, renal disease and dia...
Source: Biochemical and Biophysical Research communications - October 31, 2017 Category: Biochemistry Authors: Prud'homme GJ, Glinka Y, Kurt M, Liu W, Wang Q Tags: Biochem Biophys Res Commun Source Type: research

Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity Metabolism
In conclusion, the relatively low endogenous Spl expression level in insulin-secreting cells contributes to their extraordinary vulnerability to proinflammatory cytokine toxicity and may therefore represent a promising target for β-cell protection in type 1 diabetes mellitus.
Source: Journal of Biological Chemistry - December 8, 2017 Category: Chemistry Authors: Claudine Hahn, Karolina Tyka, Julie D. Saba, Sigurd Lenzen, Ewa Gurgul-Convey Tags: Molecular Bases of Disease Source Type: research

Effect of β-arrestin on damage of human umbilical vein endothelial cell induced by angiotensin II.
CONCLUSIONS: ARRB2 could protect the damage of HUVECs induced by Ang II and the mechanism was associated with upregulation of the expression of apoptosis and anti-apoptosis protein of Bcl-2. PMID: 29272019 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 24, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Bile acids stimulate cholangiocyte fluid secretion by activation of membraneTMEM16A Cl ‐ channels
Conclusion: Bile acids stimulate Cl‐ secretion in mouse and human biliary cells through activation of membrane TMEM16A channels in a process regulated by extracellular ATP and [Ca2+]i. These studies suggest that TMEM16A channels may be targets to increase bile flow during cholestasis. This article is protected by copyright. All rights reserved.
Source: Hepatology - January 23, 2018 Category: Internal Medicine Authors: Qin Li, Amal Dutta, Charles Kresge, Abhijit Bugde, Andrew P. Feranchak Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research

Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding.
CONCLUSION: The repression of TBX21 expression by high-affinity binding of YY1 to the -1993C allele may contribute to a decreased development of AIH-1 via suppression of type 1 immunity. PMID: 29358858 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Sun W, Wu HY, Chen S Tags: World J Gastroenterol Source Type: research

Regulatory effects of Nr4a2 on Th2 cells from patients with pemphigus vulgaris.
Authors: Chen J, Zhang Y, Liang Y, Zhao M, Long H, Xiao R, Wu H, Liao J, Luo S, Zhang G, Lu Q Abstract Pemphigus vulgaris is an autoimmune blistering disease characterized by a loss of epidermal cell-cell adhesion caused by anti-desmoglein (Dsg) autoantibodies. The pathogenesis of PV remains unclear. However, abnormal frequency and function of Th2 cells are believed to contribute to PV. We investigated Nr4a2, a transcription factor, which has been found to regulate T cell differentiation, for its association with Th2 cell differentiation and functions in PV. We found significantly decreased mRNA and protein levels ...
Source: Oncotarget - March 16, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research