Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes

Conclusions
Inhibition of HDAC3 in RA FLS largely recapitulates the effects of pan-HDACi in suppressing inflammatory gene expression, including type I IFN production in RA FLS. Our results identify HDAC3 as a potential therapeutic target in the treatment of RA and type I IFN-driven autoimmune diseases.

Source: Annals of the Rheumatic Diseases - December 8, 2016 Category: Rheumatology Authors: Angiolilli, C., Kabala, P. A., Grabiec, A. M., Van Baarsen, I. M., Ferguson, B. S., Garcia, S., Malvar Fernandez, B., McKinsey, T. A., Tak, P. P., Fossati, G., Mascagni, P., Baeten, D. L., Reedquist, K. A. Tags: Open access Basic and translational research Source Type: research