Bile acids stimulate cholangiocyte fluid secretion by activation of membraneTMEM16A Cl ‐ channels

Conclusion: Bile acids stimulate Cl‐ secretion in mouse and human biliary cells through activation of membrane TMEM16A channels in a process regulated by extracellular ATP and [Ca2+]i. These studies suggest that TMEM16A channels may be targets to increase bile flow during cholestasis. This article is protected by copyright. All rights reserved.

Source: Hepatology - January 23, 2018 Category: Internal Medicine Authors: Qin Li, Amal Dutta, Charles Kresge, Abhijit Bugde, Andrew P. Feranchak Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research