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Condition: Ischemic Stroke
Cancer: Neuroblastoma

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Total 54 results found since Jan 2013.

Long non-coding SNHG1 in cancer
ConclusionSNHG1 likely acts as a useful tumour biomarker for cancer diagnosis, prognosis and treatment.
Source: Clinica Chimica Acta - March 6, 2019 Category: Laboratory Medicine Source Type: research

Long non-coding SNHG1 in cancer.
CONCLUSION: SNHG1 likely acts as a useful tumour biomarker for cancer diagnosis, prognosis and treatment. PMID: 30849309 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - March 4, 2019 Category: Chemistry Authors: Thin K, Tu JC, Sudheesh C Tags: Clin Chim Acta Source Type: research

Long non-coding RNA AK038897 aggravates cerebral ischemia/reperfusion injury via acting as a ceRNA for miR-26a-5p to target DAPK1.
Abstract Emerging evidence has suggested a significant role of long non-coding RNAs (lncRNAs) in ischemic stroke by acting as competing endogenous RNAs (ceRNAs) for microRNAs (miRNAs) to regulate certain RNA transcripts. AK038897 is an lncRNA that was reported to be upregulated in rat brains in response to transient focal ischemia. We aimed to investigate the possible regulatory role of AK038897 in ischemic stroke. We detected increased AK038897 and decreased miR-26a-5p levels in mouse brains following middle cerebral artery occlusion/reperfusion (MCAO/R) and in neuro-2A (N2a) neuroblastoma cells following oxygen-...
Source: Experimental Neurology - January 28, 2019 Category: Neurology Authors: Wei R, Zhang L, Hu W, Wu J, Zhang W Tags: Exp Neurol Source Type: research

Amelioration of oxidative stress in differentiated neuronal cells by rutin regulated by a concentration switch
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Banudevi Sivanantham, UmaMaheswari Krishnan, Vignesh RajendiranAbstractIncreasing studies have implicated superfluous production of reactive oxygen species (ROS) as a significant factor in the progress of neurodegenerative disorders ranging from ischemic stroke to amyotrophic lateral sclerosis. The possible mechanisms relating to oxidative stress and neurodegeneration are yet to be thoroughly understood. Rutin, a flavonoid, has been well documented for its beneficial and pharmacological activities against diverse targets. However, th...
Source: Biomedicine and Pharmacotherapy - September 11, 2018 Category: Drugs & Pharmacology Source Type: research

Neuroprotective Effects of Isosteviol Sodium through Increasing CYLD by the Downregulation miRNA-181b.
In this study, we found that miR-181b expression was significantly decreased in N2A neuroblastoma cells after CoCl2-induced hypoxic injury in vitro. We further found, via western blot analysis and quantitative polymerase chain reaction assay, that altering miR-181b expression could induce changes in one of its target proteins, cylindromatosis (CYLD). Specifically, upregulation and downregulation of miR-181b (through transfection of either pre- or small interfering miR-181b, respectively) could negatively regulate CYLD protein levels as well as N2A cell survival rate and apoptosis following CoCl2-induced injury. Furthermore...
Source: Brain Research Bulletin - May 25, 2018 Category: Neurology Authors: Zhang H, Zan J, Zhong K, Lu M, Sun X, Tan W Tags: Brain Res Bull Source Type: research

4-((5-(Tert-butyl)-3-chloro-2-hydroxybenzyl) amino)-2-hydroxybenzoic acid protects against oxygen-glucose deprivation/reperfusion injury
Publication date: 1 July 2018 Source:Life Sciences, Volume 204 Author(s): Yuexinzi Jin, Xuelian Tang, Xiang Cao, Linjie Yu, Jian Chen, Haoran Zhao, Yan Chen, Lijuan Han, Xinyu Bao, Fei Li, Yun Xu Aims Oxidative stress is one of the most important pathological mechanisms which could aggravate ischemic stroke injury. In order to seek for better treatment therapies to alleviate stroke injury, novel chemicals have been synthetized. In the present study, a new compound 4-((5-(tert-butyl)-3-chloro-2-hydroxybenzyl) amino)-2- hydroxybenzoic acid, named LX009, was used to determine whether it could reduce the oxidative stress caus...
Source: Life Sciences - May 18, 2018 Category: Biology Source Type: research

Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF- κB pathway by targeting FOXO3.
Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-κB pathway by targeting FOXO3. Exp Cell Res. 2018 Apr 28;: Authors: Guo D, Ma J, Li T, Yan L Abstract Dysfunction of the microRNA (miR) network has been emerging as a main regulator in ischemic stroke. Recently, studies have linked the deregulation of miR-122 to ischemic stroke. However, the specific role and molecular mechanism of miR-122 in ischemic stroke remain to be further investigated. Here, we found that miR-122 was decreased in mouse N2A neuroblastoma (N2A) cells af...
Source: Experimental Cell Research - April 28, 2018 Category: Cytology Authors: Guo D, Ma J, Li T, Yan L Tags: Exp Cell Res Source Type: research

MicroRNA-29b alleviates oxygen and glucose deprivation/reperfusion-induced injury via inhibition of the p53-dependent apoptosis pathway in N2a neuroblastoma cells.
Authors: Cao L, Zhang Y, Zhang S, Jiang TP, Chen L, Liu J, Zhou S Abstract Cerebral ischemic injury causes severe brain damage and remains one of the leading causes of morbidity and mortality worldwide. Members of the microRNA-29 (miR-29) family are involved in regulating the process of ischemia and may be developed as biomarkers to diagnose and treat cerebral ischemia. The role of miR-29b in cerebral ischemia injury remains poorly understood. The purpose of the present study was to investigate whether miR-29b overexpression suppressed cerebral ischemic injury and to explore its underlying mechanism of action. The ...
Source: Experimental and Therapeutic Medicine - February 6, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke
ConclusionCurcumin promotes neuron survival in vivo and in vitro to exert neuroprotective effects against ischemia injury. Moreover, our results for the first time demonstrated curcumin inhibited ischemia‐induced mitochondrial apoptosis via restricting Bax activation, which may be one of the possible mechanisms underlying the neuroprotective effects of curcumin. Curcumin promotes neuron survival in vivo and in vitro to exert neuroprotective effects against ischemia injury. Moreover, our results for the first time demonstrated curcumin inhibited ischemia‐induced mitochondrial apoptosis via restricting Bax activation, w...
Source: Brain and Behavior - December 1, 2017 Category: Neurology Authors: Cai ‐Jun Xie, Ai‐Ping Gu, Jun Cai, Yi Wu, Rui‐Cong Chen Tags: ORIGINAL RESEARCH Source Type: research

Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation
In this study, we investigated the effects of SIRT6 overexpression in regulating I/R injury in a mouse cerebral I/R model in vivo and in oxygen-glucose-deprivation/reoxygenation (OGD/R)-stimulated neuro-2a neuroblastoma cells in vitro. We found that cerebral I/R (1 h/24 h) resulted in decreased SIRT6 expression in the cerebral cortex (P < 0.01). SIRT6 overexpression in the brain by in vivo gene transfer enhanced the antioxidant NRF2 signaling (P < 0.05), reduced oxidative stress (P < 0.05), and attenuated cerebral I/R-induced brain tissue damage and neurological deficits (P <...
Source: Neuroscience - November 15, 2017 Category: Neuroscience Source Type: research

MiR-29b expression is associated with a dexmedetomidine-mediated protective effect against oxygen-glucose deprivation-induced injury to SK-N-SH cells in vitro.
Abstract Ischemic cerebral stroke is a leading cause of death and long-term disability world-wide. Neuronal injury following cerebral ischemia initiates a complex series of signaling cascades that lead to neuronal cell death. MicroRNA 29b (miR-29b) has reported involvement in the pathogenic process of ischemic brain injury. Dexmedetomidine (Dex) is a highly selective α2 adrenergic receptor stimulant that exerts a protective effect on brain tissue. To determine whether Dex might directly influence miR-29b expression after an ischemic injury, human neuroblastoma SK-N-SH cells were subjected to oxygen-glucose depriv...
Source: Cell Biology International - October 31, 2017 Category: Cytology Authors: Huang Z, Liu G, Zeng Q, Gao R, Zhang S, Wang L, Liu B, Yu Y, Zhao A, Li R, Zhou S, Yu W Tags: Cell Biol Int Source Type: research

Dual anti-ischemic effects of rosmarinic acid n-butyl ester via alleviation of DAPK-p53-mediated neuronal damage and microglial inflammation.
In conclusion, these results reveal for the first time the potential anti-ischemic effects of RABE on neuronal and glial cells and elucidate the molecular mechanisms involved in its dual beneficial profiles in vitro. RABE may be a promising drug lead/candidate for the treatment of ischemic stroke. PMID: 28216621 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - February 19, 2017 Category: Drugs & Pharmacology Authors: Wu L, Wang HM, Li JL, Feng HX, Zhao WM, Zhang HY Tags: Acta Pharmacol Sin Source Type: research

Neurotrophic and neuroprotective effects of oxyntomodulin in neuronal cells and a rat model of stroke.
In this study, the neuroprotective effect of OXM was first examined in human neuroblastoma (SH-SY5Y) cells and rat primary cortical neurons. GLP-1R and GCGR antagonists, and inhibitors of various signaling pathways were used in cell culture to characterize the mechanisms of action of OXM. To evaluate translation in vivo, OXM-mediated neuroprotection was assessed in a 60-min, transient middle cerebral artery occlusion (MCAo) rat model of stroke. We found that OXM dose- and time-dependently increased cell viability and protected cells from glutamate toxicity and oxidative stress. These neuroprotective actions of OXM were mai...
Source: Experimental Neurology - November 13, 2016 Category: Neurology Authors: Li Y, Wu KJ, Yu SJ, Tamargo IA, Wang Y, Greig NH Tags: Exp Neurol Source Type: research

Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects.
Authors: Isgrò MA, Bottoni P, Scatena R Abstract Neuron-specific enolase (NSE) is known to be a cell specific isoenzyme of the glycolytic enzyme enolase. In vertebrate organisms three isozymes of enolase, expressed by different genes, are present: enolase α is ubiquitous; enolase β is muscle-specific and enolase γ is neuron-specific. The expression of NSE, which occurs as γγ- and αγ-dimer, is a late event in neural differentiation, thus making it a useful index of neural maturation.NSE is a highly specific marker for neurons and peripheral neuroendocrine cells. As a result of the findings of NSE in specific...
Source: Advances in Experimental Medicine and Biology - November 6, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Thiosulfate Mediates Cytoprotective Effects of Hydrogen Sulfide Against Neuronal Ischemia Stroke
Conclusions The protective effects of H2S are mediated by thiosulfate that is transported across cell membrane by NaS-2 and exerts antiapoptotic effects via persulfidation of caspase-3. Given the established safety track record, thiosulfate may be therapeutic against ischemic brain injury.
Source: JAHA:Journal of the American Heart Association - November 6, 2015 Category: Cardiology Authors: Marutani, E., Yamada, M., Ida, T., Tokuda, K., Ikeda, K., Kai, S., Shirozu, K., Hayashida, K., Kosugi, S., Hanaoka, K., Kaneki, M., Akaike, T., Ichinose, F. Tags: Stroke Source Type: research