Dual anti-ischemic effects of rosmarinic acid n-butyl ester via alleviation of DAPK-p53-mediated neuronal damage and microglial inflammation.

In conclusion, these results reveal for the first time the potential anti-ischemic effects of RABE on neuronal and glial cells and elucidate the molecular mechanisms involved in its dual beneficial profiles in vitro. RABE may be a promising drug lead/candidate for the treatment of ischemic stroke. PMID: 28216621 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28216621?dopt=Abstract

Source: Acta Pharmacologica Sinica - February 19, 2017 Category: Drugs & Pharmacology Authors: Wu L, Wang HM, Li JL, Feng HX, Zhao WM, Zhang HY Tags: Acta Pharmacol Sin Source Type: research