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Total 147 results found since Jan 2013.
Serum Vitamin D and Risk of Breast Cancer within Five Years
Conclusions:
In this cohort of women with elevated risk, high serum 25(OH)D levels and regular vitamin D supplement use were associated with lower rates of incident, postmenopausal breast cancer over 5 y of follow-up. These results may help to establish clinical benchmarks for 25(OH)D levels; in addition, they support the hypothesis that vitamin D supplementation is useful in breast cancer prevention. https://doi.org/10.1289/EHP943
About This Article
Received: 09 August 2016
Revised: 23 January 2017
Accepted: 06 February 2017
Published: 06 July 2017
Address correspondence to C. R. Weinberg, 111 TW Alexander Dr., Rese...
Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts
Conclusions:
Although further confirmation is required, the findings from this study suggest that PFAS exposures during pregnancy may influence lipid metabolism and glucose tolerance and thus may impact the health of the mother and her child. https://doi.org/10.1289/EHP1062
Received: 7 September 2016
Revised: 5 October 2017
Accepted: 9 October 2017
Published: 13 November 2017
Address correspondence to M. Vrijheid, ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), 88 Doctor Aiguader, 08003 Barcelona, Catalonia, Spain. Telephone: 93 214 73 46. Email: martine.vrijheid@isglobal.org
Supplemental Material ...
Source: EHP Research - November 13, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
Conclusions and Perspectives
In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human dis...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research
Bioactivities and Extract Dereplication of Actinomycetales Isolated From Marine Sponges
This study aimed to contribute to the need of finding new and more effective bioactive molecules against several of the earlier mentioned threats faced by human kind nowadays. For this, eighteen species from the Actinomycetales previously isolated from Erylus spp. sponges collected in Portuguese marine waters (Açores, Madeira, and continental shelf) were screened for antimicrobial, anti-cancer, anti-parasitic and anti-obesogenic activities.
Materials and Methods
Biological Material
The bacteria under study belong to the order Actinomycetales within the phylum Actinobacteria and were isolated from marine sponges o...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research
The Potential Use of DCE-MRI Texture Analysis to Predict HER2 2+ Status
Conclusion: The texture analysis for breast DCE-MRI proposed in this study demonstrated potential utility in HER2 2+ status discrimination.
Background
Human epidermal growth factor receptor 2 (HER2) is an orphan tyrosine kinase receptor. It is reported that HER2 is overexpressed in 15–20% of breast cancers. Overexpression of HER2 in breast cancer correlates with shortened disease-free survival. Compared with HER2-negative patients, patients with HER2-positive breast cancers have a poor prognosis, a high probability of lymph node metastasis and a high risk of recurrence (1–3). However, previous s...
Source: Frontiers in Oncology - April 11, 2019 Category: Cancer & Oncology Source Type: research
Human, Nonhuman Primate, and Bat Cells Are Broadly Susceptible to Tibrovirus Particle Cell Entry
Discussion
Tibroviruses are highly undercharacterized rhabdoviruses with unknown pathogenic potential. All isolated tibroviruses (BAV, BHV, CPV, SWBV, and TIBV) have only been found in biting midge vectors or in various, apparently healthy non-human mammals (Cybinski et al., 1980; Standfast et al., 1984; Cybinski and Gard, 1986; Gibbs et al., 1989). The discovery of BASV, EKV-1, and EKV-2 genomes in human sera (Grard et al., 2012; Stremlau et al., 2015) suggests that at least some tibroviruses could infect humans. Because BASV was discovered in the serum of a severely ill individual, tibroviruses should be considered pote...
Source: Frontiers in Microbiology - April 25, 2019 Category: Microbiology Source Type: research
Diagnosis and Treatment of Adrenocortical Oncocytoma: Case Report of Five Cases and Review of the Literature
Conclusions: The diagnosis of adrenocortical oncocytoma mainly depends on the pathological examination. Surgical resection is the main treatment method.
Introduction
The oncocytic adrenocortical neoplasm is a rare tumor of the adrenal gland. Since it was first reported in 1986 (1), there has been serial case reports to try to illuminate this rare tumor. However, there is still rather little information available, especially the pathological and follow-up data, to illustrate the biological behavior of this particular tumor. The origin, biological behavior, diagnostic criteria, and prognosis of oncocytic adrenocortic...
Source: Frontiers in Oncology - May 1, 2019 Category: Cancer & Oncology Source Type: research
Gene Therapy Leaves a Vicious Cycle
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4*
1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States
2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States
3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States
4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - April 23, 2019 Category: Cancer & Oncology Source Type: research
Programmed Death Receptor 1 (PD1) Knockout and Human Telomerase Reverse Transcriptase (hTERT) Transduction Can Enhance Persistence and Antitumor Efficacy of Cytokine-Induced Killer Cells Against Hepatocellular Carcinoma.
CONCLUSIONS PD-1 knockout combined with hTERT transduction could prolong the lifespan and enhance antitumor efficacy of CIK cells against hepatocellular carcinoma cell line.
PMID: 29967316 [PubMed - in process]
Source: Medical Science Monitor - July 4, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Long non-coding RNA PVT1 regulates the migration of hepatocellular carcinoma HepG2 cells via miR-3619-5p/MKL1 axis.
In this study, we investigated the relationship between PVT1 and MKL1 as a novel regulatory mechanism underlying HCC progression. We used HepG2 and Cos‑7 cell lines. Transfection experiments with miR-3619-5p mimics/inhibitor, PVT1, siRNA-PVT1, MKL1, or siRNA-MKL1 were performed. RNA and protein levels were analyzed by quantitative reverse transcription PCR and Western blot, respectively. Cell migration was assessed by Transwell assay. Luciferase assays, RNA-FISH, RNA immunoprecipitation, and chromatin immunoprecipitation assays were performed to confirm the interaction between PVT1, miR-3619-5p, and MKL1 in HCC cells. Ov...
Source: Bosnian Journal of Basic Medical Sciences - March 12, 2020 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Sarcomatoid carcinoma of the prostate with bladder invasion shortly after androgen deprivation: Two case reports
CONCLUSION: The sarcomatoid component of SC may arise from one of the specific groups of cancer cells that are resistant to hormonal therapy. Morphological characteristics of SCs can present as "red hepatization" and "fish flesh". SCs grow rapidly and have a poor prognosis, and thus, extensive TURP plus radiation may be the treatment of choice.PMID:33728311 | PMC:PMC7942028 | DOI:10.12998/wjcc.v9.i7.1668
Source: Clinical Genitourinary Cancer - March 17, 2021 Category: Cancer & Oncology Authors: Wei Wei Qi-Guang Li Xian Long Gao-Hua Hu Hua-Jie He Yuan-Bi Huang Xian-Lin Yi Source Type: research
PRR34-AS1 sponges miR-498 to facilitate TOMM20 and ITGA6 mediated tumor progression in HCC
CONCLUSION: PRR34-AS1 facilitates HCC progression by regulating miR-498/TOMM20/ITGA6 axis.PMID:33609562 | DOI:10.1016/j.yexmp.2021.104620
Source: Experimental and Molecular Pathology - February 20, 2021 Category: Pathology Authors: Xuejing Yang Dong Song Junping Zhang Xuejing Yang Huijing Feng Jianian Guo Source Type: research
Long non-coding RNA muskelin 1 antisense RNA (MKLN1-AS) is a potential diagnostic and prognostic biomarker and therapeutic target for hepatocellular carcinoma
CONCLUSIONS: MKLN1-AS overexpression enhances the stability of YAP1 mRNA, which is necessary for the oncogenic activity of MKLN1-AS. MKLN1-AS can be utilized in the diagnosis and prognosis of hepatocellular carcinoma as an upstream factor of YAP1.PMID:33878313 | DOI:10.1016/j.yexmp.2021.104638
Source: Experimental and Molecular Pathology - April 20, 2021 Category: Pathology Authors: Chao Guo Shuhuang Zhou Weimin Yi Pingzhou Yang Ou Li Jianming Liu Chuang Peng Source Type: research
