Serum Vitamin D and Risk of Breast Cancer within Five Years

Conclusions: In this cohort of women with elevated risk, high serum 25(OH)D levels and regular vitamin D supplement use were associated with lower rates of incident, postmenopausal breast cancer over 5 y of follow-up. These results may help to establish clinical benchmarks for 25(OH)D levels; in addition, they support the hypothesis that vitamin D supplementation is useful in breast cancer prevention. https://doi.org/10.1289/EHP943 About This Article Received: 09 August 2016 Revised: 23 January 2017 Accepted: 06 February 2017 Published: 06 July 2017 Address correspondence to C. R. Weinberg, 111 TW Alexander Dr., Research Triangle Park, NC 27709 USA. Telephone: (919) 541-4927; Email: weinber2@niehs.nih.gov Supplemental Material is available online (https://doi.org/10.1289/EHP943). The authors declare that they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Supplemental Material PDF (160 KB) Note to readers with disabilities: EHP has provided a 508-conformant...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

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Hereditary forms of distal renal tubular acidosis (dRTA) are rare and mainly caused by mutations in ATP6V1B1, ATP6V0A4 and SLC4A1. About 20 mutations in SLC4A1 gene have been found that are related to either autosomal dominant (AD) or autosomal recessive dRTA. AD dRTA often manifest as constitutional and can easily be delayed in diagnosis and treatment. A 30-year-old male patient has a history of paroxysmal paralysis for 7 years, presenting with mild hypokalemia, alkalization of urine, normal blood PH value and increased urinary calcium. Patient ’s father has similar presentations but never came to the hospital. We f...
Source: Nephron - Category: Urology & Nephrology Source Type: research
ConclusionsThe onset of a second primary tumour was related with the primary treatment given; thus the risk for those treated with radiotherapy and androgen deprivation therapy more than doubled.ResumenIntroducción y objetivosLa aparición de segundos tumores primarios en pacientes con cáncer de próstata de alto riesgo debe tenerse en cuenta en la evolución natural de la enfermedad. Nuestro objetivo es evaluar la influencia del tratamiento primario con intención curativa de dichos pacientes en el desarrollo de segundos tumores primarios.Material y métodosEstudio retrospectivo...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
ConclusionThe PET scan showed similar sensitivity for urological tumours to the standard imaging techniques but with higher specificity, positive predictive value and negative predictive value. This led to a change in treatment strategy for 40% of the patients in our series. The PET scan will probably become the standard test in the extension and follow-up studies of most urological tumours.ResumenIntroducciónEn los últimos años han surgido nuevos estudios de imagen en diagnóstico y seguimiento de tumores urológicos metastásicos.Material y métodosSe revisa a 41 pacientes con...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
Publication date: Available online 13 December 2018Source: Actas Urológicas Españolas (English Edition)Author(s): J.M. Cózar, B. Miñana, F. Gómez-Veiga, A. Rodríguez-Antolín, GESCAP GroupAbstractAimsTo describe the 3-year progression-free survival (PFS), overall survival (OS) and disease-specific mortality in the prospective prostate cancer GESCAP cohort, as well as the progression to castration resistance in patients on hormone therapy.Material and methodsProspective, observational, epidemiological, multicentre study. Of the 4087 patients recruited, 3843 were evaluable. The...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
ConclusionsThe diagnostic performance of CB in patients with at least one previous negative biopsy was 44%, increasing according to the PI-RADS grade, and low in PI-RADS 3. No clinical variable predictive of cancer was found in patients with PI-RADS 3.ResumenIntroducciónEvaluación de la efectividad de la biopsia cognitiva (BC) en los pacientes con sospecha clínica de cáncer de próstata (caP) y al menos una biopsia negativa (BTR).Material y métodoAnálisis retrospectivo de 144 pacientes con al menos una BTR y una resonancia magnética nuclear (RMN) previa. Los nód...
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
Conclusion: A significant relation was found between high UA value and PCal in this study. These results may show that UA plays an active role in PCal etiology.Urol Int
Source: Urologia Internationalis - Category: Urology & Nephrology Source Type: research
This study aims to investigate the relationship between tunnel driving occupational environment and hearing loss in tra...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Occupational Issues Source Type: news
Relations among gender, ethnicity, athlete seasonal status, alcohol consumption, and protective behavioral strategies were examined among student-athletes. The national sample (N  = 670, Mage = 18.90) included Black (n = 199), Hispani...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
The objectives of this study are, first, to explore the prevalence of lifetime violent and criminal behaviors among alcohol, opioid, and synthetic cannabinoid (SC) users in the treatment program; second, to examine and compare sociodemographic c...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
[Abstract unavailable] Language: en...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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