The Potential Use of DCE-MRI Texture Analysis to Predict HER2 2+ Status

Conclusion: The texture analysis for breast DCE-MRI proposed in this study demonstrated potential utility in HER2 2+ status discrimination. Background Human epidermal growth factor receptor 2 (HER2) is an orphan tyrosine kinase receptor. It is reported that HER2 is overexpressed in 15–20% of breast cancers. Overexpression of HER2 in breast cancer correlates with shortened disease-free survival. Compared with HER2-negative patients, patients with HER2-positive breast cancers have a poor prognosis, a high probability of lymph node metastasis and a high risk of recurrence (1–3). However, previous studies have demonstrated that patients with HER2-positive breast cancers have a favorable clinical response to trastuzumab (4, 5). It is therefore critical to determine the HER2 status of a patient for treatment selection as well as for predicting therapeutic response. Two methods have been adopted in the field for detecting HER2 status: immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). HER2 expression is typically divided into four categories: 0, 1+, 2+, 3+. For HER2 IHC measurements, a score of 0 or 1+ are considered negative, and a score of 3+ is considered positive. For HER2 2+ cases, IHC cannot be used to confirm this status, and HER2 2+ status must instead be tested using FISH (6, 7). However, the FISH assay is typically cost-prohibitive. In addition, further testing is time-consuming and often can delay treatment. A novel cost-effectiv...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 16 July 2019Source: The Egyptian RheumatologistAuthor(s): Amany R. El-Najjar, ahmed A. elsammakAbstractAim of the workTo study the effects of serum homocysteine (Hcy) on arterial wall properties, as a contributing risk factor for arterial atherosclerosis and thrombosis.Patients and methodsFifty Behçet's disease (BD) patients (M/F:37/13; age:34.8 ± 8.5 years) along with 50 healthy controls (M/F:32/18; age:31.9 ± 8.1 years) matched for age, sex, blood pressure, heart rate, height, total cholesterol and glucose levels were included. All were recruited Zagazig...
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
Publication date: Available online 16 July 2019Source: Journal of Advanced ResearchAuthor(s): Laura Botta, Luigino Dal Maso, Stefano Guzzinati, Chiara Panato, Gemma Gatta, Annalisa Trama, Massimo Rugge, Giovanna Tagliabue, Claudia Casella, Bianca Caruso, Maria Michiara, Stefano Ferretti, Flavio Sensi, Rosario Tumino, Federica Toffolutti, Antonio Giampiero Russo, Anna Luisa Caiazzo, Lucia Mangone, Walter Mazzucco, Silvia IacovacciAbstractThe aims of this study were to provide life expectancy (LE) estimates of cancer patients at diagnosis and LE changes over time since diagnosis to describe the impact of cancer during patien...
Source: Journal of Advanced Research - Category: Research Source Type: research
Publication date: Available online 16 July 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): Joshua Ryan, Vasantha Aaron, Justin SimsAbstractThe increasing availability of hybrid PET/MRI systems has led to a breadth of new publications and opportunities for use of PET/MRI. While PET/CT has been a valuable tool for oncologic staging, including head and neck malignancy, there are several theoretical and practical advantages a PET/MRI system would have over PET/CT in head and neck imaging. This review article discusses the established role of PET/CT, early evidence for the role of PET/MRI, and protocol considerations f...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Publication date: Available online 16 July 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): Cody R. Larson, Richard H. Wiggins
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Publication date: Available online 16 July 2019Source: NeuroImage: ClinicalAuthor(s): Alexa Haeger, Ana S. Costa, Jörg B. Schulz, Kathrin ReetzAbstractCurrent treatment in late-life cognitive impairment and dementia is still limited, and there is no cure for brain tissue degeneration or reversal of cognitive decline. Physical activity represents a promising non-pharmacological interventional approach in many diseases causing cognitive impairment, but its effect on brain integrity is still largely unknown. Especially research of cerebral alterations in disease state that goes beyond observations of clinical improvement...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 16 July 2019Source: Journal of NeuroradiologyAuthor(s): Hui Chen, Ying Li, Bin Jiang, Guangming Zhu, Paymon Garakani Rezaii, Lu Gang, Max WintermarkAbstractPurpose. - To characterize the demographics, clinical and imaging findings, and outcomes of traumatic brain injury (TBI) patients in each of NeuroImaging Radiological Interpretation System (NIRIS) categories.Material and Methods. - We considered all consecutive patients transported to Stanford Hospital’s emergency department by ambulance or helicopter between November 2015 and April 2017. We retained adult patients (> 18 years...
Source: Journal of Neuroradiology - Category: Radiology Source Type: research
ConclusionPICC placement led by technicians is feasible and safe without statistical difference in terms of complications compared to PICC placement made by radiologists.
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
This study examined whether a novel, detector-based spectral CT scanner (SDCT) may improve subjective assessment of different types of pancreatic lesions and if various quantitative maps may improve lesion contrast and differentiation.Materials and methods61 consecutive patients who underwent clinical, contrast-agent enhanced, abdominal SDCT scans and showed pancreatic lesions of different origins were included. Subjective image analysis was performed by two readers who assessed image quality, lesion conspicuity and diagnostic confidence on 5-point Likert scales for conventional polyenergetic reconstructions (polyE), virtu...
Source: European Journal of Radiology - Category: Radiology Source Type: research
Publication date: Available online 17 July 2019Source: Academic RadiologyAuthor(s): Henkjan Huisman
Source: Academic Radiology - Category: Radiology Source Type: research
ConclusionIt is feasible to use CNN based algorithm to accurately distinguish cancerous regions in OCT images. This fully automated method can overcome limitations of manual interpretation including interobserver variability and speed of interpretation and may enable real-time intraoperative margin assessment.
Source: Academic Radiology - Category: Radiology Source Type: research
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