The Potential Use of DCE-MRI Texture Analysis to Predict HER2 2+ Status

Conclusion: The texture analysis for breast DCE-MRI proposed in this study demonstrated potential utility in HER2 2+ status discrimination. Background Human epidermal growth factor receptor 2 (HER2) is an orphan tyrosine kinase receptor. It is reported that HER2 is overexpressed in 15–20% of breast cancers. Overexpression of HER2 in breast cancer correlates with shortened disease-free survival. Compared with HER2-negative patients, patients with HER2-positive breast cancers have a poor prognosis, a high probability of lymph node metastasis and a high risk of recurrence (1–3). However, previous studies have demonstrated that patients with HER2-positive breast cancers have a favorable clinical response to trastuzumab (4, 5). It is therefore critical to determine the HER2 status of a patient for treatment selection as well as for predicting therapeutic response. Two methods have been adopted in the field for detecting HER2 status: immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). HER2 expression is typically divided into four categories: 0, 1+, 2+, 3+. For HER2 IHC measurements, a score of 0 or 1+ are considered negative, and a score of 3+ is considered positive. For HER2 2+ cases, IHC cannot be used to confirm this status, and HER2 2+ status must instead be tested using FISH (6, 7). However, the FISH assay is typically cost-prohibitive. In addition, further testing is time-consuming and often can delay treatment. A novel cost-effectiv...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 7 July 2020Source: The American Journal of SurgeryAuthor(s): Kurt S. Schultz, Susanna W.L. de Geus, Teviah E. Sachs, Ryan B. Morgan, Sing Chau Ng, David McAneny, Jennifer F. Tseng
Source: The American Journal of Surgery - Category: Surgery Source Type: research
The objectives of this paper are the presentation of a sample of patients with PC undergoing treatment with androgen deprivation therapy (ADT) in usual clinical practice and the determination of parameters associated with the development of resistance to castration (CRPC). MATERIAL AND METHODS: Multicenter, observational, retrospective study that analyzes patients treated with ADT from January 2016 to January 2017. Descriptive analysis of the most relevant clinical variables and univariante analysis and progression times by Kaplan-Meier test. RESULTS: Sample of 952 patients. At PC diagnosis median age 74 years. Med...
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
CONCLUSIONS: We concluded that despite the fact that the plasmacytoid variant of BC is rare, it is important to take into account the pathologic and clinical features of this tumor in order to manage the optimal treatment of this poor prognosis cancer. PMID: 32633253 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
Authors: Castro-Diaz DM, Padilla-Fernández B, Correa Corchete MJ Abstract OBJECTIVES: To Evaluate the severity of symptoms in OAB patients and their outcomes expectations, symptoms management and Health-Related Quality of Life (HRQoL). MATERIAL AND METHODS: Epidemiological, multicentre, non-interventional, cross-sectional study, conducted by 294 physicians in Spain in clinical practice. Female adult patients with OAB symptoms, newly diagnosed or during follow-up were included. B-SAQ, OABq-SF and an ad-hoc patient expectation questionnaire were completed. Association between expectations, symptom severity...
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
CONCLUSIONS: The probabilistic model presented showed a greater persistence in patients treated with mirabegron compared to AM, leading to a positive impactin patients quality of life, as well cost savings to the NHS in Spain. PMID: 32633246 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
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Source: Headlines - Category: Radiology Source Type: news
CONCLUSION: To address flaws in conceptualisation and the resulting gaps in knowledge, we suggest a definition and a theoretical framework that are suited to allow heterogeneity in the field, but enables the development of sound interventions, as well as facilitate the interpretation of intervention effectiveness. PMID: 32631110 [PubMed - in process]
Source: European Journal of General Practice - Category: Primary Care Tags: Eur J Gen Pract Source Type: research
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