Bioactivities and Extract Dereplication of Actinomycetales Isolated From Marine Sponges

This study aimed to contribute to the need of finding new and more effective bioactive molecules against several of the earlier mentioned threats faced by human kind nowadays. For this, eighteen species from the Actinomycetales previously isolated from Erylus spp. sponges collected in Portuguese marine waters (Açores, Madeira, and continental shelf) were screened for antimicrobial, anti-cancer, anti-parasitic and anti-obesogenic activities. Materials and Methods Biological Material The bacteria under study belong to the order Actinomycetales within the phylum Actinobacteria and were isolated from marine sponges of the genus Erylus, E. discophorus (Berg01 and Berg02, from the continental shelf at Berlengas, Portugal) and E. deficiens (#91, from the continental shelf at Gorringe, Portugal) and E. mamillaris (SM, Açores, Portugal) (Table 1). Most of these strains showed the presence of interesting secondary metabolism genes and/or bioactivities in previous antimicrobial screenings (Table 1; Graca et al., 2013, 2015). TABLE 1 Table 1. List of Actinomycetales used in this study evidencing their physiological affiliation and bioactive potential. For the antimicrobial assays six different pathogens were tested, Escherichia coli ATCC25922 (EcoWT), Klebsiella pneumoniae ATCC 700603, Methicillin-resistant Staphylococcus aureus MB5393 (MRSA), Staphylococcus aureus ATCC29213 (MSSA), Acinetobacter. baumannii MB5973 Aspergillus fumigatus ATCC46645, and Can...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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