Bioactivities and Extract Dereplication of Actinomycetales Isolated From Marine Sponges
This study aimed to contribute to the need of finding new and more effective bioactive molecules against several of the earlier mentioned threats faced by human kind nowadays. For this, eighteen species from the Actinomycetales previously isolated from Erylus spp. sponges collected in Portuguese marine waters (Açores, Madeira, and continental shelf) were screened for antimicrobial, anti-cancer, anti-parasitic and anti-obesogenic activities. Materials and Methods Biological Material The bacteria under study belong to the order Actinomycetales within the phylum Actinobacteria and were isolated from marine sponges of the genus Erylus, E. discophorus (Berg01 and Berg02, from the continental shelf at Berlengas, Portugal) and E. deficiens (#91, from the continental shelf at Gorringe, Portugal) and E. mamillaris (SM, Açores, Portugal) (Table 1). Most of these strains showed the presence of interesting secondary metabolism genes and/or bioactivities in previous antimicrobial screenings (Table 1; Graca et al., 2013, 2015). TABLE 1 Table 1. List of Actinomycetales used in this study evidencing their physiological affiliation and bioactive potential. For the antimicrobial assays six different pathogens were tested, Escherichia coli ATCC25922 (EcoWT), Klebsiella pneumoniae ATCC 700603, Methicillin-resistant Staphylococcus aureus MB5393 (MRSA), Staphylococcus aureus ATCC29213 (MSSA), Acinetobacter. baumannii MB5973 Aspergillus fumigatus ATCC46645, and Can...
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Hyun Ji Son, Ha Yoon Mo, Nam Jin Yoo, Sug Hyung Lee
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Jamal Halajzadeh, Parisa Maleki Dana, Zatollah Asemi, Mohammad Ali Mansournia, Bahman Yousefi
Publication date: Available online 12 July 2020Source: Pathology - Research and PracticeAuthor(s): Milena Vuletic, Snezana Jancic, Sanja Milenkovic, Marinko Paunovic, Biljana Milicic, Nina Jancic, Biljana Perunicic, Zivana Slovic
Ranging from the skin to liver, body has an in-built detox system that keeps it running smoothly on a daily basis. Due to the present life-style, increased stress, pollution, unhealthy dietary habits, the natural system gets weakened. The need of present time is to unveil the herbs present in the nature full of detox potential, inheriting the capacity to purify the kidney, liver, gut, skin and blood. These herbal detoxifiers facilitate lungs, aids kidneys, facilitates digestive tract and skin. The present review deals with the study of herbs under the category of detoxifiers for kidney, liver, gut, skin and blood. The herb...
Conclusion: Food preferences are acquired in childhood and sound nutritional practices should be established in childhood to prevent lifestyle disorders and premature aging. Though CR is a known and preferred non-pharmacological intervention in the management of obesity, its implemention has not been explored and evaluated extensively. This is a vital area that needs scientific research as the goals of obesity managements are no longer just weight loss through dietary restrictions. An interdisciplinary method to lifestyle modification in the management of adolescent obesity addressing all physiological and psychosocial aspects is recommended.
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