An evaluation of HHV-6 as an etiologic agent in Hodgkin lymphoma and brain cancer using IARC criteria for oncogenicity
Human herpesvirus-6 (HHV-6) is a ubiquitous double-stranded DNA virus that can cause roseola infantum, encephalitis, and seizure disorders. Several studies have shown an association between HHV-6 and cancer bu... (Source: Infectious Agents and Cancer)
Source: Infectious Agents and Cancer - November 5, 2019 Category: Cancer & Oncology Authors: Michael J. Wells, Steven Jacobson and Paul H. Levine Tags: Review Source Type: research
Inflammatory Cytokine Profile in Individuals with Inherited Chromosomally Integrated Human Herpesvirus 6
Human Herpesvirus 6 (HHV-6) is a Roseolovirus that comprises two distinct species, HHV-6A and HHV-6B [1]. While HHV-6B is known to cause roseola infantum (exanthema subitum or sixth disease), a generally mild illness characterized by fever and rash [2], the pathology of HHV-6A is largely unknown. Most children are infected by HHV-6B by the age of 3 years, and the seropositivity in the general population reaches up to 95% [3]. The virus can infect a variety of cells including CD4+ T-lymphocytes [3]. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - October 30, 2019 Category: Hematology Authors: Daniel P. Weschke, Wendy M. Leisenring, Richard L. Lawler, Terry Stevens-Ayers, Meei-Li Huang, Keith R. Jerome, Danielle M. Zerr, John A. Hansen, Michael Boeckh, Joshua A. Hill Source Type: research
HHV-6B reduces autophagy and induces ER stress in primary monocytes impairing their survival and differentiation into dendritic cells.
In this study we found that HHV-6 B derived from patients affected by exanthema subitum impaired monocyte differentiation into DCs, as the infected cells acquired less CD1a DC marker and retained more CD14 monocyte marker. In agreement with the previous finding that HHV-6B dysregulated autophagy and induced endoplasmic reticulum (ER) stress in cells in which it replicated, here we found that these effects occurred also in differentiating monocytes and that ER stress relief, by using the chemical chaperone sodium 4-phenylbutirate (PBA), partially restored DC formation. This suggests that the induction of ER stress, likely e...
Source: Virus Research - September 11, 2019 Category: Virology Authors: Romeo MA, Gilardini Montani MS, Falcinelli L, Gaeta A, Nazzari C, Faggioni A, Cirone M Tags: Virus Res Source Type: research
Clinical, laboratorial diagnosis and prophylaxis of measles in Brazil
ABSTRACT Measles is an acute febrile exanthematic disease of viral etiology, highly contagious, being the cause of morbidity and mortality of children in developing countries, whereas it has become rarer in developed countries due to vaccination. Its differential diagnosis should be made with other childhood viral respiratory diseases such as influenza, rhinovirus and adenovirus, and exanthematic febrile diseases such as rubella, roseola and varicella. In tropical regions, it should be performed with dengue, zika and chikungunya. Its clinical picture presents the following phases: incubation, usually asymptomatic; a prodro...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - September 3, 2019 Category: Pathology Source Type: research
Chapter Eight - Entry of betaherpesviruses
Publication date: 2019Source: Advances in Virus Research, Volume 104Author(s): Mitsuhiro Nishimura, Yasuko MoriAbstractIn this chapter, we present an overview on betaherpesvirus entry, with a focus on human cytomegalovirus, human herpesvirus 6A and human herpesvirus 6B. Human cytomegalovirus (HCMV) is a complex human pathogen with a genome of 235 kb encoding more than 200 genes. It infects a broad range of cell types by switching its viral ligand on the virion, using the trimer gH/gL/gO for infection of fibroblasts and the pentamer gH/gL/UL128/UL130/UL131 for infection of other cells such as epithelial and endothelial...
Source: Advances in Virus Research - August 20, 2019 Category: Virology Source Type: research
Entry of betaherpesviruses
Publication date: Available online 21 June 2019Source: Advances in Virus ResearchAuthor(s): Mitsuhiro Nishimura, Yasuko MoriAbstractIn this chapter, we present an overview on betaherpesvirus entry, with a focus on human cytomegalovirus, human herpesvirus 6A and human herpesvirus 6B. Human cytomegalovirus (HCMV) is a complex human pathogen with a genome of 235 kb encoding more than 200 genes. It infects a broad range of cell types by switching its viral ligand on the virion, using the trimer gH/gL/gO for infection of fibroblasts and the pentamer gH/gL/UL128/UL130/UL131 for infection of other cells such as epithelial an...
Source: Advances in Virus Research - June 22, 2019 Category: Virology Source Type: research
Human Herpesvirus 6 Infection after Autologous Stem Cell Transplantation: A Multicenter Prospective Study in Adult Patients
Human herpesvirus type 6 (HHV-6) is a widespread roseolovirus which encompasses two different variants: HHV-6A and HHV-6B sharing 75%-95% nucleotide sequence identity. Variant B is the most commonly detected in clinical specimens: it is considered as the causative agent of the exanthema subitum childhood disease with an estimated seroprevalence of> 95% after the age of 2 years and of pathologies described in immunocompromised patients 1-3. To date, variant A seems less frequently detected 4. Like other herpesviruses, HHV-6 establishes a life-long latency; involved organs are brain, bone marrow and salivary glands, with a s...
Source: Journal of Infection - May 6, 2019 Category: Infectious Diseases Authors: Marie Balsat, Sylvie Pillet, Emmanuelle Tavernier, Victoria Cacheux, Vanessa Escuret, C écile Moluçon-Chabrot, Karine Augeul-Meunier, Audrey Mirand, Christel Regagnon, Fabien Tinquaut, Véronique Bousser, Mathieu Oriol, Denis Guyotat, Gilles Salles, Jac Source Type: research
SOCS and Herpesviruses, With Emphasis on Cytomegalovirus Retinitis
Christine I. Alston1,2 and Richard D. Dix1,2*
1Department of Biology, Viral Immunology Center, Georgia State University, Atlanta, GA, United States
2Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, United States
Suppressor of cytokine signaling (SOCS) proteins provide selective negative feedback to prevent pathogeneses caused by overstimulation of the immune system. Of the eight known SOCS proteins, SOCS1 and SOCS3 are the best studied, and systemic deletion of either gene causes early lethality in mice. Many viruses, including herpesviruses such as herpes simplex virus and cytomega...
Source: Frontiers in Immunology - April 10, 2019 Category: Allergy & Immunology Source Type: research
The rash with maculopapules and fever in children
Several medical conditions can cause children to present with fever and a maculopapular rash Although some presentations are benign, others may be medical emergencies, which warrant a prompt diagnosis. We review some of the more common causes of fever and maculopapular dermatitirs, rash including infectious processes (roseola; rubeola; rubella; parvovirus B19; hand, foot, and mouth disease; scarlet fever; meningococcemia; Epstein-Barr virus infection), hypersensitivity reactions (exanthematous drug reactions), and vasculitis syndromes (Kawasaki disease). (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - February 28, 2019 Category: Dermatology Authors: Sonal Muzumdar, Marti Jill Rothe, Jane M. Grant-Kels Source Type: research
Nonomuraea mangrovi sp. nov., an actinomycete isolated from mangrove soil.
Abstract
A novel aerobic actinomycete, designated HA15826T, was isolated from a mangrove soil sample collected in Sanya, China. Scanning electron microscopy revealed that the isolate produced straight to slightly flexural spore chains with rough cylindrical spores. Chemotaxonomic tests showed that the cell wall contained meso-diaminopimelic acid and the major fatty acids were iso-C16 : 0, 10-methyl-C17 : 0, C17 : 1ω8c and C16 : 0. 16S rRNA gene sequence similarity analysis showed that strain HA15826T belonged to the genus Nonomuraea, being most closely related to Nonomuraea dietziae DSM 44...
Source: International Journal of Systematic and Evolutionary Microbiology - September 4, 2018 Category: Microbiology Authors: Huang H, Liu M, Zhong W, Mo K, Zhu J, Zou X, Hu Y, Bao S Tags: Int J Syst Evol Microbiol Source Type: research
High incidence of early human Herpes Virus-6 infection in children undergoing haploidentical manipulated stem cell transplantation for haematological malignancies
Human Herpesvirus 6 (HHV-6) is a member of the Roseolovirus genus belonging to Betaherpesvirus subfamily of human herpes viruses. Two HHV-6 species have been identified, HHV-6A and HHV-6B, which exhibit different biological characteristics and pattern of host diseases [1]. HHV-6B is highly prevalent in the human population, affecting over 90% of healthy individuals during childhood, while HHV-6A is less frequent [2]. Primary HHV-6 infection is recognized as the cause of exanthema subitum and fever [3]. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - July 29, 2018 Category: Hematology Authors: Katia Perruccio, Luisa Sisinni, Antonio Perez-Martinez, Jaime Valentin, Ilaria Capolsini, Maria Speranza Massei, Maurizio Caniglia, Simone Cesaro Source Type: research
Encephalitis associated with human herpesvirus-7 infection in an immunocompetent adult
Primary Human herpesvirus-7 (HHV-7) infection usually occurs during childhood and causes several clinical manifestations: mainly exanthem subitum (roseola infantum), followed by a lifelong latent state with possi... (Source: Virology Journal)
Source: Virology Journal - May 25, 2017 Category: Virology Authors: M ónica Parra, Adoración Alcala, Cristina Amoros, Anna Baeza, Antonio Galiana, David Tarragó, Miguel Ángel García-Quesada and Victoria Sánchez-Hellín Source Type: research
Increased interleukin-1 β and basic fibroblast growth factor levels in the cerebrospinal fluid during human herpesvirus-6B (HHV-6B) encephalitis.
Increased interleukin-1β and basic fibroblast growth factor levels in the cerebrospinal fluid during human herpesvirus-6B (HHV-6B) encephalitis.
Biochem Biophys Res Commun. 2017 Mar 22;:
Authors: Tamai M, Kobayashi N, Shimada K, Oka N, Takahashi M, Tanuma A, Tanemoto T, Namba H, Saito Y, Wada Y, Okamoto A, Ida H, Kondo K
Abstract
Human herpesvirus 6B (HHV-6B) causes exanthema subitum in infants and is known to be mildly pathogenic. However, HHV-6B infection can induce febrile seizures in a high percentage of patients, and in rare cases, result in encephalitis. We detected higher ...
Source: Biochemical and Biophysical Research communications - March 22, 2017 Category: Biochemistry Authors: Tamai M, Kobayashi N, Shimada K, Oka N, Takahashi M, Tanuma A, Tanemoto T, Namba H, Saito Y, Wada Y, Okamoto A, Ida H, Kondo K Tags: Biochem Biophys Res Commun Source Type: research
Life cycle traits of Philodina roseola Ehrenberg, 1830 (Rotifera, Bdelloidea), a model organism for bioassays.
Abstract
This paper describes experimental results on the life cycle of the rotifer Philodina roseola cultured in the laboratory. Detailed information on life-cycle parameters of a certain species provides a deep understanding and contributes to a better knowledge of the role of the species in the community, besides providing data that are basic to other ecological investigations such as secondary production estimates and knowledge for applications such as its utilization as test-organism in ecotoxicological studies. The average duration of embryonic development of P. roseola was 23.88 h, the age at maturi...
Source: An Acad Bras Cienc - May 9, 2016 Category: Science Authors: Moreira RA, Mansano AS, Rocha O Tags: An Acad Bras Cienc Source Type: research
Efficient Identification of Inherited Chromosomally Integrated Human Herpesvirus 6 Using Specimen Pooling
Human herpesvirus 6 (HHV-6) species B infects>95% of people during childhood and causes exanthema subitum (roseola) [1]. HHV-6B frequently reactivates in immunocompromised patients and causes significant morbidity [2]. The epidemiology of HHV-6A infection is poorly understood, and this virus does not have clear disease associations. Like other herpesviruses, HHV-6A and HHV-6B establish life-long latency after primary infection. However, they have a unique ability to establish latency by integrating into chromosomal telomeres [3,4]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - February 20, 2016 Category: Virology Authors: Joshua A Hill, Ruth Hall-Sedlak, Amalia Magaret, Meei-Li Huang, Danielle M Zerr, Keith R Jerome, Michael Boeckh Source Type: research
