Focal Coxsackie virus B5 encephalitis with synchronous seizure cluster and eruption: Infantile case
Abstract
Enterovirus focal encephalitis is a rare clinical entity that is characterized by focal neurological signs including seizure, hemiparesis, hemichorea, and headache, which are mainly followed by rapid spontaneous improvement. We herein describe the case of a 9‐month‐old boy who developed Coxsackie virus B5 (CVB5) focal encephalitis with seizure clusters in the eruption stage of roseola infantum‐like illness, which were followed by rapid improvement and benign outcome. Lumbar puncture indicated pleocytosis, and CVB5 infection in the cerebrospinal fluid was subsequently identified on genome sequencing and virus...
Source: Pediatrics International - December 29, 2015 Category: Pediatrics Authors: Tadashi Shiohama, Taku Omata, Kaori Muta, Kazuo Kodama, Katsunori Fujii, Naoki Shimojo Tags: Patient Report Source Type: research
Prevalence of HHV-6 in cerebrospinal fluid of children younger than 2 years of age with febrile convulsion.
CONCLUSION: These findings showed that primary infection with HHV-6 is frequently associated with febrile convulsion in infants which may be at risk for subsequent development of epilepsy.
PMID: 25705358 [PubMed] (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - December 12, 2015 Category: Microbiology Tags: Iran J Microbiol Source Type: research
Viral Skin Diseases.
Abstract
In the vast world of skin diseases, viral skin disorders account for a significant percentage. Most viral skin diseases present with an exanthem (skin rash) and, oftentimes, an accompanying enanthem (lesions involving the mucosal membrane). In this article, the various viral skin diseases are explored, including viral childhood exanthems (measles, rubella, erythema infectiosum, and roseola), herpes viruses (herpes simplex virus, varicella zoster virus, Kaposi sarcoma herpes virus, viral zoonotic infections [orf, monkeypox, ebola, smallpox]), and several other viral skin diseases, such as human pap...
Source: Primary Care - November 30, 2015 Category: Primary Care Authors: Ramdass P, Mullick S, Farber HF Tags: Prim Care Source Type: research
Viral Skin Diseases
In the vast world of skin diseases, viral skin disorders account for a significant percentage. Most viral skin diseases present with an exanthem (skin rash) and, oftentimes, an accompanying enanthem (lesions involving the mucosal membrane). In this article, the various viral skin diseases are explored, including viral childhood exanthems (measles, rubella, erythema infectiosum, and roseola), herpes viruses (herpes simplex virus, varicella zoster virus, Kaposi sarcoma herpes virus, viral zoonotic infections [orf, monkeypox, ebola, smallpox]), and several other viral skin diseases, such as human papilloma virus, hand, foot, ...
Source: Primary Care: Clinics in Office Practice - November 25, 2015 Category: Primary Care Authors: Priya Ramdass, Sahil Mullick, Harold F. Farber Source Type: research
Common Skin Rashes in Children.
Abstract
Because childhood rashes may be difficult to differentiate by appearance alone, it is important to consider the entire clinical presentation to help make the appropriate diagnosis. Considerations include the appearance and location of the rash; the clinical course; and associated symptoms, such as pruritus or fever. A fever is likely to occur with roseola, erythema infectiosum (fifth disease), and scarlet fever. Pruritus sometimes occurs with atopic dermatitis, pityriasis rosea, erythema infectiosum, molluscum contagiosum, and tinea infection. The key feature of roseola is a rash presenting after ...
Source: American Family Physician - August 1, 2015 Category: Primary Care Authors: Allmon A, Deane K, Martin KL Tags: Am Fam Physician Source Type: research
Quantitative Detection of Human Herpesvirus-6 with Digital Droplet PCR in a Patient with Post-Transplant HHV-6 Encephalitis (P6.305)
CONCLUSIONS:HHV-6 viral DNA levels in the periphery or CSF may not correlate with ongoing active infection in the CNS, as there may be very low levels in the periphery, yet very high levels in brain tissue. In active HHV-6 infection, this virus is found in higher levels in the limbic and midline structures, which may correlate with clinical symptoms. DdPCR is a very useful tool in the accurate and precise quantification of HHV-6 viral DNA.Disclosure: Dr. Billioux has nothing to disclose. Dr. Jacobson has nothing to disclose. (Source: Neurology)
Source: Neurology - April 8, 2015 Category: Neurology Authors: Billioux, B. J., Jacobson, S. Tags: HTLV and Other Viral Infections Source Type: research
Quantitative Detection of Human Herpesvirus-6 with Digital Droplet PCR in a Patient with Post-Transplant HHV-6 Encephalitis (I4-5E)
CONCLUSIONS:HHV-6 viral DNA levels in the periphery or CSF may not correlate with ongoing active infection in the CNS, as there may be very low levels in the periphery, yet very high levels in brain tissue. In active HHV-6 infection, this virus is found in higher levels in the limbic and midline structures, which may correlate with clinical symptoms. DdPCR is a very useful tool in the accurate and precise quantification of HHV-6 viral DNA.Disclosure: Dr. Billioux has nothing to disclose. Dr. Jacobson has nothing to disclose. (Source: Neurology)
Source: Neurology - April 8, 2015 Category: Neurology Authors: Billioux, B. J., Jacobson, S. Tags: Infectious, Paraneoplastic, and Autoimmune Encephalopathies: Advances in Clinical Diagnosis and Emerging Insights about Pathogenesis Poster Presentations Source Type: research
Laboratory and Clinical Aspects of Human Herpesvirus 6 Infections.
Abstract
Human herpesvirus 6 (HHV-6) is a widespread betaherpesvirus which is genetically related to human cytomegalovirus (HCMV) and now encompasses two different species: HHV-6A and HHV-6B. HHV-6 exhibits a wide cell tropism in vivo and, like other herpesviruses, induces a lifelong latent infection in humans. As a noticeable difference with respect to other human herpesviruses, genomic HHV-6 DNA is covalently integrated into the subtelomeric region of cell chromosomes (ciHHV-6) in about 1% of the general population. Although it is infrequent, this may be a confounding factor for the diagnosis of active v...
Source: Clinical Microbiology Reviews - March 14, 2015 Category: Microbiology Authors: Agut H, Bonnafous P, Gautheret-Dejean A Tags: Clin Microbiol Rev Source Type: research
Multiple primary syphilis on the lip, nipple–areola and penis: An immunohistochemical examination of Treponema pallidum localization using an anti‐T. pallidum antibody
We describe a case of primary syphilis at three sites in genital and extragenital regions of a man who had sex with men. A 29‐year‐old man visited our hospital for skin lesions on his lower lip, nipple–areola and penis. A positive syphilis serological test for rapid plasma reagin had a titer of 1:16; the patient also tested positive for specific antibodies against T. pallidum, with a cut‐off index of 39.0. Histopathological examination of a nipple–areola biopsy specimen revealed a thickened epidermis and dense infiltration of inflammatory cells extending from the upper dermal layers to the deep dermis. The infla...
Source: The Journal of Dermatology - February 24, 2015 Category: Dermatology Authors: Hidetsugu Fukuda, Misaki Takahashi, Keiichi Kato, Toshiaki Oharaseki, Hideki Mukai Tags: Concise Communication Source Type: research
Human herpesvirus-6 infection-associated acute encephalopathy without skin rash
Human herpesvirus-6 (HHV-6) is the etiological agent of exanthema subitum-associated encephalopathy, which usually occurs in children younger than 3years. Brain imaging shows various abnormalities. (Source: Brain and Development)
Source: Brain and Development - January 9, 2015 Category: Neurology Authors: Shiho Yamamoto, Satoru Takahashi, Ryosuke Tanaka, Akie Okayama, Akiko Araki, Harutaka Katano, Keiko Tanaka-Taya, Hiroshi Azuma Tags: Case Report Source Type: research
Roseoloviruses: unmet needs and research priorities Perspective
Publication date: December 2014 Source:Current Opinion in Virology, Volume 9 Author(s): Mary T Caserta , Laurie T Krug , Philip E Pellett The human roseoloviruses, human herpesviruses 6A (HHV-6A), HHV-6B, and HHV-7, are highly prevalent viruses that typically cause fever/rash illnesses such as roseola during early life primary infections. They also cause significant neurologic disease and complications following stem cell and solid organ transplantation, and have suggestive but less certain etiologic associations with other neurologic diseases and immunologic disorders. The US National Institute of Allergy and Infec...
Source: Current Opinion in Virology - November 27, 2014 Category: Virology Source Type: research
Roseoloviruses: unmet needs and research priorities
Publication date: December 2014 Source:Current Opinion in Virology, Volume 9 Author(s): Mary T Caserta , Laurie T Krug , Philip E Pellett The human roseoloviruses, human herpesviruses 6A (HHV-6A), HHV-6B, and HHV-7, are highly prevalent viruses that typically cause fever/rash illnesses such as roseola during early life primary infections. They also cause significant neurologic disease and complications following stem cell and solid organ transplantation, and have suggestive but less certain etiologic associations with other neurologic diseases and immunologic disorders. The US National Institute of Allergy and Infec...
Source: Current Opinion in Virology - November 16, 2014 Category: Virology Source Type: research
Chromosomally integrated human herpesvirus 6 in heart failure: prevalence and treatment
ConclusionVirus replication in cardiac tissue of ciHHV‐6 heart failure patients suggests that ciHHV‐6 reactivation causes persistence of unexplained heart failure symptoms. We demonstrated that antiviral treatment, effective in decreasing viral transcripts and clinical complaints of cardiomyopathies, is a new therapeutic option for ciHHV‐6‐associated diseases. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - November 1, 2014 Category: Cardiology Authors: Uwe Kühl, Dirk Lassner, Nina Wallaschek, Ulrich M. Gross, Gerhard R.F. Krueger, Bettina Seeberg, Benedikt B. Kaufer, Felicitas Escher, Wolfgang Poller, Heinz‐Peter Schultheiss Tags: Original Article Source Type: research
Clinical impact of primary infection with roseoloviruses
Publication date: December 2014 Source:Current Opinion in Virology, Volume 9 Author(s): Brenda L Tesini , Leon G Epstein , Mary T Caserta The roseoloviruses, human herpesvirus-6A -6B and -7 (HHV-6A, HHV-6B and HHV-7) cause acute infection, establish latency, and in the case of HHV-6A and HHV-6B, whole virus can integrate into the host chromosome. Primary infection with HHV-6B occurs in nearly all children and was first linked to the clinical syndrome roseola infantum. However, roseolovirus infection results in a spectrum of clinical disease, ranging from asymptomatic infection to acute febrile illnesses with severe ...
Source: Current Opinion in Virology - November 1, 2014 Category: Virology Source Type: research
Concentration dependent inhibitory effect of a nucleoside-based analog, 2,2-bis-hydroxymethyl-cyclopropavir, against human herpesvirus-6 replication
Human herpesvirus-6 (HHV-6) is a ubiquitous virus with the human adult population being greater than 90% seropositive. Primary infections occur by the age of two years and result in the childhood disease, roseola infantum. Infected individuals retain a persistent lifelong infection but typically remain asymptomatic. However, HHV-6 has been associated with certain neurological disorders such as multiple sclerosis (MS). Antiviral therapies against human herpesviruses include a variety of targets such as reverse transcriptase and integrase inhibitors; the enzymes required for viral genome replication and integration, respecti...
Source: Journal of Neuroimmunology - October 15, 2014 Category: Allergy & Immunology Authors: , Emily Leibovitch, Steven Jacobson Tags: 167 Source Type: research
