Quantitative Detection of Human Herpesvirus-6 with Digital Droplet PCR in a Patient with Post-Transplant HHV-6 Encephalitis (I4-5E)

CONCLUSIONS:HHV-6 viral DNA levels in the periphery or CSF may not correlate with ongoing active infection in the CNS, as there may be very low levels in the periphery, yet very high levels in brain tissue. In active HHV-6 infection, this virus is found in higher levels in the limbic and midline structures, which may correlate with clinical symptoms. DdPCR is a very useful tool in the accurate and precise quantification of HHV-6 viral DNA.Disclosure: Dr. Billioux has nothing to disclose. Dr. Jacobson has nothing to disclose.

Source: Neurology - April 8, 2015 Category: Neurology Authors: Billioux, B. J., Jacobson, S. Tags: Infectious, Paraneoplastic, and Autoimmune Encephalopathies: Advances in Clinical Diagnosis and Emerging Insights about Pathogenesis Poster Presentations Source Type: research