Human Herpes Virus 6 in human epilepsy: Data from surgical resections
Human Herpes Virus 6 is a ubiquitous virus, with a seroprevalence approaching 100% in the general population. There are two variants of HHV-6, A and B, which have been determined to be separate species. HHV-6B is the etiologic agent of roseola, while HHV-6A is associated with central nervous system disorders and may be more neurotropic than HHV-6B. HHV-6 has been associated with epilepsy, particularly with prolonged febrile seizures in children and mesial temporal lobe epilepsy (MTLE). Prolonged febrile seizures have been linked to the later development of MTLE. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - October 15, 2014 Category: Allergy & Immunology Authors: , Emily Leibovitch, Giovanna Brunetto, Irene Dustin, Sara Inati, John Schreiber, Chigo Eze, Kareem Zaghloul, Steve Jacobson, William Theodore Tags: 163 Source Type: research
HHV-7 in adults with drug-resistant epilepsy: A pathological role in hippocampal sclerosis?
Human herpesvirus-7 (HHV-7) is a β-herpesvirus that was first isolated in 1990 [1]. It has been detected in normal brain tissue but not more frequently than HHV-6 [2]. HHV-7 has a high degree of homology to HHV-6 and is associated with febrile seizures in influenza encephalopathy or exanthema subitum [3,4]. A recent study suggested an association between HHV-6B/HHV-7 and febrile status epilepticus [5]. To date, few data are available that support a possible association between HHV-7 and drug-resistant epilepsy. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - August 28, 2014 Category: Virology Authors: Jin-Mei Li, Cheng Huang, Bo Yan, Wei Wang, Qiao Zhou, Josemir W. Sander, Dong Zhou Source Type: research
Coexistence of Philodina roseola (Rotifera: Bdelloidea) with larvae of Aedes aegypti in India.
This study was undertaken to determine the co-existence and prevalence of Philodina roseola and other Bdelloid rotifers in the container habitats of Ae. aegypti mosquitoes. The investigation was conducted in 43 villages which belong to four districts in South India, affected by the epidemic of either dengue or Chikungunya fever. A total of 2093 houses and 12980 containers were examined for Aedes breeding and those containers with Aedes larvae were chosen for further investigation. The investigation showed that, the P. roseola was found associated in 502 (98.2%) containers, P. roseola along with other Philodina sp. in 126 c...
Source: Tropical Biomedicine - June 1, 2014 Category: Tropical Medicine Authors: Muniaraj M, Sathish Babu R Tags: Trop Biomed Source Type: research
Fatal Human Herpesvirus 6–Associated Encephalitis in Two Boys With Underlying Mitochondrial Disorders
Human herpesvirus 6 is a significant cause of the febrile illness roseola infantum in young children. Infection with human herpesvirus 6 typically causes a self-limited febrile illness but occasionally is associated with central nervous system manifestations, including febrile seizures and encephalitis. Host factors associated with severe manifestations of human herpesvirus 6–associated neurological disease remain poorly characterized. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 14, 2014 Category: Neurology Authors: Duha Al-Zubeidi, Mathula Thangarajh, Sheel Pathak, Chunyu Cai, Bradley L. Schlaggar, Gregory A. Storch, Dorothy K. Grange, Michael E. Watson Tags: Clinical Observations Source Type: research
Roseola infantum and its causal human herpesviruses
Abstract
Roseola infantum, also known as exanthem subitum or sixth disease, is a generally benign febrile exanthem of infancy. It has a characteristic clinical course of high fever followed by the appearance of an exanthem upon defervescence. Febrile seizures are a frequent complication. Roseola is caused by infection with human herpesviruses 6 or 7 (HHV‐6/7), which are acquired at a young age. Diagnosis is made by serology or by virus detection in body fluids and tissues. Treatment of roseola is supportive; recovery is usually complete with no significant sequelae. However, HHV‐6/7 can reactivate in immunocompetent as...
Source: International Journal of Dermatology - February 14, 2014 Category: Dermatology Authors: Rivka C. Stone, Giuseppe A. Micali, Robert A. Schwartz Tags: Review Source Type: research
Acute childhood exanthems
This article describes the common exanthems, including measles, rubella, varicella, erythema infectiosum, papular-purpuric gloves and socks syndrome, roseola infantum, hand, foot and mouth disease, Gianotti–Crosti syndrome, unilateral laterothoracic exanthem and pityriasis rosea. It outlines their transmission, infectivity, prodrome, clinical presentation, complications and treatment. Although it is often difficult to identify the specific virus, polymerase chain reaction analysis has improved diagnostic accuracy, which is particularly important in immunocompromised individuals and pregnant women. Alternative diagnoses i...
Source: Medicine - December 23, 2013 Category: Internal Medicine Authors: Penelope A. Bryant, Cathryn M. Lester Tags: Viral infections Source Type: research
Quantification of two viral transcripts by real time PCR to investigate human herpesvirus type 6 active infection
Conclusion: The new assays are sensitive and reliable methods for the monitoring of viral transcription in vitro and in vivo. As their detection is associated to high DNA loads in vivo, they can be helpful tools for the diagnosis of active infection. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - December 9, 2013 Category: Virology Authors: Céline Bressollette-Bodin, Thi Van Ha Nguyen, Marina Illiaquer, Bernard Besse, Cécile Peltier, Patrice Chevallier, Berthe-Marie Imbert-Marcille Tags: Full length articles Source Type: research
[A case of neurological syphilis mimicking Horton's disease and polymyalgia rheumatica.]
CONCLUSION: Symptoms evocative of Horton's disease and polymyalgia rheumatica can reveal syphilis, a disease dubbed "the great simulator" on account of the variety of clinical forms it can take.
PMID: 24090892 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - October 1, 2013 Category: Dermatology Authors: Leroux M, Pasquet A, Baclet V, Alcaraz I, Melliez H, Cheret A Tags: Ann Dermatol Venereol Source Type: research
Guillain-Barré in a 10-month-old: diagnostic challenges in a pediatric emergency
A 10-month-old male infant presented to the emergency department (ED) with a chief complaint of weakness, decreased mobility, and regression of motor milestones over a period of 6 days. Significant medical history included a Roseola infection 5 weeks before ED presentation. The patient's pediatrician and chiropractor had both previously diagnosed the patient with strains and sprains. After progression of symptoms, the patient presented to the ED and was discharged home to follow up as an outpatient. The patient subsequently returned to the ED and was admitted to neurology with concern for Guillain-Barré syndrome, which wa...
Source: The American Journal of Emergency Medicine - September 18, 2013 Category: Emergency Medicine Authors: Kseniya Orlik, Gregory D. Griffin Tags: Case Reports Source Type: research
The Long-Term Outcomes of Patients Transplanted Due to Acute Liver Failure With Hepatic Human Herpesvirus-6 Infection
Abstract:
Human herpesvirus (HHV)-6, comprised of HHV-6A and HHV-6B, belongs to the betaherpesviruses that infect 95%–100% of humans. Primary infection, known as exanthema subitum, occurs in early childhood. Reactivations of latent HHV-6, mostly HHV-6B, are common after liver transplantation. The vast majority of them are asymptomatic; in a minority of cases, the virus may infect the liver transplant, causing graft dysfunction or hepatitis. An association between hepatic HHV-6 infection and indeterminate acute liver failure (ALF) has been shown, but the causality is not clear because of the ubiquitous nature of HHV-6. W...
Source: Transplantation Proceedings - June 1, 2013 Category: Transplant Surgery Authors: M. Härmä, K. Höckerstedt, I. Lautenschlager Tags: Liver Transplantation Source Type: research
Mapping the telomere integrated genome of human herpesvirus 6A and 6B.
Abstract
Human herpesvirus 6B (HHV-6B) is the causative agent of roseola infantum. HHV-6A and 6B can reactivate in immunosuppressed individuals and are linked with severe inflammatory response, organ rejection and central nervous system diseases. About 0.85% of the US and UK population carries an integrated HHV-6 genome in all nucleated cells through germline transmission. We have previously reported that the HHV-6A genome integrated in telomeres of patients suffering from neurological dysfunction and also in telomeres of tissue culture cells. We now report that HHV-6B also integrates in telomeres during l...
Source: Virology - May 3, 2013 Category: Virology Authors: Arbuckle JH, Pantry SN, Medveczky MM, Prichett J, Loomis KS, Ablashi D, Medveczky PG Tags: Virology Source Type: research
