Concentration dependent inhibitory effect of a nucleoside-based analog, 2,2-bis-hydroxymethyl-cyclopropavir, against human herpesvirus-6 replication

Human herpesvirus-6 (HHV-6) is a ubiquitous virus with the human adult population being greater than 90% seropositive. Primary infections occur by the age of two years and result in the childhood disease, roseola infantum. Infected individuals retain a persistent lifelong infection but typically remain asymptomatic. However, HHV-6 has been associated with certain neurological disorders such as multiple sclerosis (MS). Antiviral therapies against human herpesviruses include a variety of targets such as reverse transcriptase and integrase inhibitors; the enzymes required for viral genome replication and integration, respectively.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Tags: 167 Source Type: research