Astrovirus reverse genetics systems, a story of success
Publication date: October 2020Source: Current Opinion in Virology, Volume 44Author(s): Carlos Sandoval-Jaime (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - July 17, 2020 Category: Virology Source Type: research

Revisiting an old friend: new findings in alphavirus structure and assembly
Publication date: December 2020Source: Current Opinion in Virology, Volume 45Author(s): Julie M Button, Shefah A Qazi, Joseph Che-Yen Wang, Suchetana Mukhopadhyay (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - July 17, 2020 Category: Virology Source Type: research

Virion structures and genome delivery of honeybee viruses
Publication date: December 2020Source: Current Opinion in Virology, Volume 45Author(s): Michaela Procházková, Karel Škubník, Tibor Füzik, Liya Mukhamedova, Antonín Přidal, Pavel Plevka (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - July 15, 2020 Category: Virology Source Type: research

Reverse genetics approaches: a novel strategy for African horse sickness virus vaccine design
Publication date: October 2020Source: Current Opinion in Virology, Volume 44Author(s): Eva Calvo-Pinilla, Alejandro Marín-López, Sergio Utrilla-Trigo, Luís Jiménez-Cabello, Javier Ortego (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - July 12, 2020 Category: Virology Source Type: research

Reverse genetics approaches of Borna disease virus: applications in development of viral vectors and preventive vaccines
Publication date: October 2020Source: Current Opinion in Virology, Volume 44Author(s): Yumiko Komatsu, Keizo Tomonaga (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - July 10, 2020 Category: Virology Source Type: research

Reverse genetic approaches for the development of Zika vaccines and therapeutics
Publication date: October 2020Source: Current Opinion in Virology, Volume 44Author(s): Camila R Fontes-Garfias, Coleman K Baker, Pei-Yong Shi (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - July 1, 2020 Category: Virology Source Type: research

Reverse genetics approaches for the development of bunyavirus vaccines
Publication date: October 2020Source: Current Opinion in Virology, Volume 44Author(s): Breanna Tercero, Shinji Makino (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - June 30, 2020 Category: Virology Source Type: research

Structural and dynamic asymmetry in icosahedrally symmetric virus capsids
Publication date: December 2020Source: Current Opinion in Virology, Volume 45Author(s): Asis K Jana, Eric R May (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - June 30, 2020 Category: Virology Source Type: research

Highly efficient vaccines for Bluetongue virus and a related Orbivirus based on reverse genetics
Publication date: October 2020Source: Current Opinion in Virology, Volume 44Author(s): Polly Roy (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - June 29, 2020 Category: Virology Source Type: research

AGL2017-82570-RReverse genetics approaches for the development of new vaccines against influenza A virus infections
Publication date: October 2020Source: Current Opinion in Virology, Volume 44Author(s): Luis Martinez-Sobrido, Marta L DeDiego, Aitor Nogales (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - June 27, 2020 Category: Virology Source Type: research

Reserve genetic approaches for the development of Zika vaccines and therapeutics
Publication date: October 2020Source: Current Opinion in Virology, Volume 44Author(s): Camila R Fontes-Garfias, Coleman K Baker, Pei-Yong Shi (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - June 20, 2020 Category: Virology Source Type: research

Potential of plasmid only based reverse genetics of rotavirus for the development of next-generation vaccines
Publication date: October 2020Source: Current Opinion in Virology, Volume 44Author(s): Ulrich Desselberger (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - June 10, 2020 Category: Virology Source Type: research

Potential for gene editing in antiviral resistance
Publication date: June 2020Source: Current Opinion in Virology, Volume 42Author(s): Douglas Euan Pyott, Yue Fei, Attila Molnar (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - June 6, 2020 Category: Virology Source Type: research

Nucleic acid-mediated PAMP-triggered immunity in plants
Publication date: June 2020Source: Current Opinion in Virology, Volume 42Author(s): Khalid Amari, Annette Niehl (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - June 4, 2020 Category: Virology Source Type: research

The continued epidemic threat of SARS-CoV-2 and implications for the future of global public health
Publication date: Available online 4 June 2020Source: Current Opinion in VirologyAuthor(s): Timothy P Sheahan, Matthew B Frieman (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - June 4, 2020 Category: Virology Source Type: research

Roles of small RNAs in the establishment of tolerant interaction between plants and viruses
Publication date: June 2020Source: Current Opinion in Virology, Volume 42Author(s): Maja Križnik, Špela Baebler, Kristina Gruden (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - May 31, 2020 Category: Virology Source Type: research

R gene mediated defense against viruses
Publication date: December 2020Source: Current Opinion in Virology, Volume 45Author(s): Peter Palukaitis, Ju-Yeon Yoon (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - May 11, 2020 Category: Virology Source Type: research

Measles virus persistence and its consequences
Publication date: April 2020Source: Current Opinion in Virology, Volume 41Author(s): Diane E Griffin (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - May 7, 2020 Category: Virology Source Type: research

Critical view on RNA silencing-mediated virus resistance using exogenously applied RNA
Publication date: June 2020Source: Current Opinion in Virology, Volume 42Author(s): Veli V Uslu, Michael Wassenegger (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - May 2, 2020 Category: Virology Source Type: research

Animal morbilliviruses and their cross-species transmission potential
Publication date: April 2020Source: Current Opinion in Virology, Volume 41Author(s): Makoto Takeda, Fumio Seki, Yuta Yamamoto, Naganori Nao, Hiroaki Tokiwa (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - April 28, 2020 Category: Virology Source Type: research

Measles pathogenesis, immune suppression and animal models
Publication date: April 2020Source: Current Opinion in Virology, Volume 41Author(s): Brigitta M Laksono, Rory D de Vries, W Paul Duprex, Rik L de Swart (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - April 25, 2020 Category: Virology Source Type: research

Seek and hide: the manipulating interplay of measles virus with the innate immune system
Publication date: April 2020Source: Current Opinion in Virology, Volume 41Author(s): Katayoun Ayasoufi, Christian K Pfaller (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - April 22, 2020 Category: Virology Source Type: research

An update on salicylic acid biosynthesis, its induction and potential exploitation by plant viruses
Publication date: June 2020Source: Current Opinion in Virology, Volume 42Author(s): Alex M Murphy, Tao Zhou, John P Carr (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - April 22, 2020 Category: Virology Source Type: research

Corrigendum to “How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency” [Curr Opin Virol 25 (August 2017) 49-58]
Publication date: Available online 4 April 2020Source: Current Opinion in VirologyAuthor(s): Christine Römer, Manvendra Singh, Laurence D Hurst, Zsuzsanna Izsvák (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - April 6, 2020 Category: Virology Source Type: research

Measles Resurgence and Drug Development
Publication date: April 2020Source: Current Opinion in Virology, Volume 41Author(s): Richard K Plemper (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - April 3, 2020 Category: Virology Source Type: research

Interplay between ABA signaling and RNA silencing in plant viral resistance
Publication date: June 2020Source: Current Opinion in Virology, Volume 42Author(s): Mazen Alazem, Na-Sheng Lin (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - March 28, 2020 Category: Virology Source Type: research

The discovery of segmented flaviviruses: implications for viral emergence
Publication date: February 2020Source: Current Opinion in Virology, Volume 40Author(s): Xu Zhang, Nina Wang, Zedong Wang, Quan Liu (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - March 25, 2020 Category: Virology Source Type: research

Influence of herd immunity in the cyclical nature of arboviruses
Publication date: February 2020Source: Current Opinion in Virology, Volume 40Author(s): Guilherme S Ribeiro, Gabriel L Hamer, Mawlouth Diallo, Uriel Kitron, Albert I Ko, Scott C Weaver (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - March 19, 2020 Category: Virology Source Type: research

Combating vaccine hesitancy and other 21st century social determinants in the global fight against measles
Publication date: April 2020Source: Current Opinion in Virology, Volume 41Author(s): Peter J Hotez, Tasmiah Nuzhath, Brian Colwell (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - February 27, 2020 Category: Virology Source Type: research

Editorial Board
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - December 7, 2019 Category: Virology Source Type: research

Reprogramming of cellular metabolic pathways by human oncogenic viruses
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): John G Purdy, Micah A LuftigOncogenic viruses, like all viruses, relies on host metabolism to provide the metabolites and energy needed for virus replication. Many DNA tumor viruses and retroviruses will reprogram metabolism during infection. Additionally, some viral oncogenes may alter metabolism independent of virus replication. Virus infection and cancer development share many similarities regarding metabolic reprogramming as both processes demand increased metabolic activity to produce biomass: cell proliferation in the case of canc...
Source: Current Opinion in Virology - November 23, 2019 Category: Virology Source Type: research

Editorial overview: Viruses and cancer
Publication date: Available online 13 November 2019Source: Current Opinion in VirologyAuthor(s): Marta M Gaglia, Karl Munger (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - November 13, 2019 Category: Virology Source Type: research

Editorial Board
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - November 11, 2019 Category: Virology Source Type: research

Editorial overview: Engineering cellular resistance towards the HIV cure
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): Chen Liang, Ben Berkhout (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - November 11, 2019 Category: Virology Source Type: research

Cytomegalovirus is a tumor-associated virus: armed and dangerous
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): Charles CobbsHuman cytomegalovirus (HCMV) gene products are present in multiple human malignancies, often in specific association with tumor cells and tumor vasculature. Emerging evidence from human and mouse models of CMV infection in cancer indicate that CMV can transform epithelial cells, promote epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial (MET) in tumor cells, promote tumor angiogenesis and proliferation and incapacitate the host anti-CMV immune response. This review will discuss the increasing role of H...
Source: Current Opinion in Virology - September 14, 2019 Category: Virology Source Type: research

Applications of CRISPR/Cas9 tools in deciphering the mechanisms of HIV-1 persistence
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): Roxane Verdikt, Gilles Darcis, Amina Ait-Ammar, Carine Van LintHIV-1 infection can be controlled but not cured by combination antiretroviral therapy. Indeed, the virus persists in treated individuals in viral reservoirs, the best described of which consisting in latently infected central memory CD4+ T cells. However, other cell types in other body compartments than in the peripheral blood contribute to HIV-1 persistence. Addressing the molecular mechanisms of HIV-1 persistence and their cell-specific and tissue-specific variations is thu...
Source: Current Opinion in Virology - September 9, 2019 Category: Virology Source Type: research

Targeting HIV-1 proviral transcription
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): Alex Olson, Binita Basukala, Wilson W Wong, Andrew J HendersonDespite the success of antiretroviral therapies, there is no cure for HIV-1 infection due to the establishment of a long-lived latent reservoir that fuels viral rebound upon treatment interruption. ‘Shock-and-kill’ strategies to diminish the latent reservoir have had modest impact on the reservoir leading to considerations of alternative approaches to target HIV-1 proviruses. This review explores approaches to target HIV-1 transcription as a way to block the provir...
Source: Current Opinion in Virology - August 30, 2019 Category: Virology Source Type: research

Dynamic factors affecting HPV-attributable fraction for head and neck cancers
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): Jitesh B Shewale, Maura L GillisonHead and neck squamous cell carcinoma (HNSCC) is attributable to carcinogen and oncogenic virus exposure and rates are driven by the prevalence, intensity, and duration of exposures. Recent dramatic shifts in human behavior have resulted in substantial heterogeneity in HNSCC incidence trends over calendar time. For example, changes in sexual behavior during the 1900s likely increased exposure to oral human papillomavirus (HPV) infection and, consequently, rates of HPV-positive HNSCC. Shifting rate-ratio...
Source: Current Opinion in Virology - August 28, 2019 Category: Virology Source Type: research

Detecting viral sequences in NGS data
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): Paul G Cantalupo, James M PipasNext generation sequencing (NGS) technologies provide an increasingly important avenue for detecting known viruses, and for discovering novel viruses present in clinical or environmental samples. Several computational pipelines capable of identifying and classifying viral sequences in NGS data have been developed and used to search for viruses in human or animal samples, microbiomes, and in various environments. In this review we summarize the different approaches used to determine viral presence in sequen...
Source: Current Opinion in Virology - August 28, 2019 Category: Virology Source Type: research

Elimination of infectious HIV DNA by CRISPR–Cas9
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): Atze T Das, Caroline S Binda, Ben BerkhoutCurrent antiretroviral drugs can efficiently block HIV replication and prevent transmission, but do not target the HIV provirus residing in cells that constitute the viral reservoir. Because drug therapy interruption will cause viral rebound from this reservoir, HIV-infected individuals face lifelong treatment. Therefore, novel therapeutic strategies are being investigated that aim to permanently inactivate the proviral DNA, which may lead to a cure. Multiple studies showed that CRISPR–Cas9...
Source: Current Opinion in Virology - August 25, 2019 Category: Virology Source Type: research

The potential of engineered antibodies for HIV-1 therapy and cure
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): Marloes Grobben, Richard AL Stuart, Marit J van GilsBroadly neutralizing antibodies (bnAbs) are currently under investigation as a therapy for HIV-1 infection and recent clinical trials have shown prolonged viral suppression by bnAbs during antiretroviral treatment interruption. Interestingly, these bnAbs also showed the ability to activate the host immune system to clear HIV-1 infected cells. There are many possibilities to further increase the potential efficacy of bnAbs. Most notably, Fc domain engineering to improve half-life and inc...
Source: Current Opinion in Virology - August 15, 2019 Category: Virology Source Type: research

Altered microRNA processing proteins in HPV-induced cancers
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): Barbara C Snoek, Iris Babion, Danijela Koppers-Lalic, Dirk M Pegtel, Renske DM SteenbergenHigh-risk human papilloma virus (hrHPV) infections are associated with the development of anogenital cancers, in particular cervical cancer, and a subset of head and neck cancers. Previous studies have shown that microRNAs (miRNAs) contribute to the development and progression of HPV-induced malignancies. miRNAs are small non-coding RNAs that exist as multiple length and sequence variants, termed isomiRs. Efficient processing of miRNAs and generati...
Source: Current Opinion in Virology - August 12, 2019 Category: Virology Source Type: research

HIV-1 persistence in the central nervous system: viral and host determinants during antiretroviral therapy
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): EF Balcom, WC Roda, EA Cohen, MY Li, C PowerDespite remarkable therapeutic advances in the past two decades, the elimination of human immunodeficiency virus type 1 (HIV-1) from latent reservoirs constitutes a major barrier to eradication and preventing neurological disease associated with HIV/AIDS. Invasion of the central nervous system (CNS) by HIV-1 occurs early in infection, leading to viral infection and productive persistence in brain macrophage-like cells (BMCs) including resident microglia and infiltrating macrophages. HIV-1 persi...
Source: Current Opinion in Virology - August 5, 2019 Category: Virology Source Type: research

Human papillomavirus vaccine disease impact beyond expectations
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): Silvia de Sanjose, Maria Brotons, D Scott LaMontagne, Laia BruniSince 2006, 115 countries and territories have introduced human papillomavirus (HPV) vaccination programs.Several efforts have been undertaken to evaluate the impact of HPV vaccines. Many countries, mainly high-income and with high screening coverage, are already reporting a visible impact of the HPV vaccine on HPV-related diseases. Others, largely low-income and middle-income countries, are introducing HPV vaccine to control HPV diseases that will undoubtedly generate a si...
Source: Current Opinion in Virology - August 3, 2019 Category: Virology Source Type: research

The case for BK polyomavirus as a cause of bladder cancer
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): Gabriel J Starrett, Christopher B BuckIn 2014, the International Agency for Research on Cancer judged Merkel cell polyomavirus (MCPyV) to be a probable human carcinogen. BK polyomavirus (BKPyV, a distant cousin of MCPyV) was ruled a possible carcinogen. In this review, we argue that it has recently become reasonable to view both of these viruses as known human carcinogens. In particular, several complementary lines of evidence support a causal role for BKPyV in the development of bladder carcinomas affecting organ transplant patients. T...
Source: Current Opinion in Virology - July 27, 2019 Category: Virology Source Type: research

BK polyomavirus is a cause of bladder cancer
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): Gabriel J Starrett, Christopher B BuckIn 2014, the International Agency for Research on Cancer judged Merkel cell polyomavirus (MCPyV) to be a probable human carcinogen. BK polyomavirus (BKPyV, a distant cousin of MCPyV) was ruled a possible carcinogen. In this review, we argue that it has recently become reasonable to view both of these viruses as known human carcinogens. In particular, several complementary lines of evidence support a causal role for BKPyV in the development of bladder carcinomas affecting organ transplant patients. T...
Source: Current Opinion in Virology - July 21, 2019 Category: Virology Source Type: research

Editorial overview: Viruses and the microbiome
Publication date: Available online 20 July 2019Source: Current Opinion in VirologyAuthor(s): Stephanie M Karst, Christiane E Wobus (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - July 21, 2019 Category: Virology Source Type: research

A broad drug arsenal to attack a strenuous latent HIV reservoir
Publication date: October 2019Source: Current Opinion in Virology, Volume 38Author(s): Mateusz Stoszko, Enrico Ne, Erik Abner, Tokameh MahmoudiHIV cure is impeded by the persistence of a strenuous reservoir of latent but replication competent infected cells, which remain unsusceptible to c-ART and unrecognized by the immune system for elimination. Ongoing progress in understanding the molecular mechanisms that control HIV transcription and latency has led to the development of strategies to either permanently inactivate the latent HIV infected reservoir of cells or to stimulate the virus to emerge out of latency, coupled t...
Source: Current Opinion in Virology - July 17, 2019 Category: Virology Source Type: research

Regulating cellular plasticity to persist: a way for tumor viruses to triumph
Publication date: December 2019Source: Current Opinion in Virology, Volume 39Author(s): Vural Yilmaz, Katerina StratiGraphical abstract (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - July 12, 2019 Category: Virology Source Type: research

Virome–host interactions in intestinal health and disease
Publication date: August 2019Source: Current Opinion in Virology, Volume 37Author(s): Sang-Uk Seo, Mi-Na KweonThe enteric virome consists largely of bacteriophages and prophages related to commensal bacteria. Bacteriophages indirectly affect the host immune system by targeting their associated bacteria; however, studies suggest that bacteriophages also have distinct pathways that enable them to interact directly with the host. Eukaryotic viruses are less abundant than bacteriophages but are more efficient in the stimulation of host immune responses. Acute, permanent, and latent viral infections are detected by different ty...
Source: Current Opinion in Virology - July 9, 2019 Category: Virology Source Type: research