Contributors
Publication date: 2020Source: Advances in Virus Research, Volume 107Author(s): (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 24, 2020 Category: Virology Source Type: research

Preface
Publication date: 2020Source: Advances in Virus Research, Volume 107Author(s): John P. Carr, Marilyn J. Roossinck (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 24, 2020 Category: Virology Source Type: research

Chapter One - Viral and subviral derived small RNAs as pathogenic determinants in plants and insects
Publication date: 2020Source: Advances in Virus Research, Volume 107Author(s): Paola Leonetti, Pascal Miesen, Ronald P. van Rij, Vitantonio Pantaleo (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 24, 2020 Category: Virology Source Type: research

Chapter Two - Hijacking of host cellular components as proviral factors by plant-infecting viruses
Publication date: 2020Source: Advances in Virus Research, Volume 107Author(s): Kiwamu Hyodo, Tetsuro Okuno (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 24, 2020 Category: Virology Source Type: research

Chapter Three - Modulation of disease severity by plant positive-strand RNA viruses: The complex interplay of multifunctional viral proteins, subviral RNAs and virus-associated RNAs with plant signaling pathways and defense responses
Publication date: 2020Source: Advances in Virus Research, Volume 107Author(s): Hélène Sanfaçon (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 24, 2020 Category: Virology Source Type: research

Chapter Four - Host protein chaperones, RNA helicases and the ubiquitin network highlight the arms race for resources between tombusviruses and their hosts
Publication date: 2020Source: Advances in Virus Research, Volume 107Author(s): Peter D. Nagy (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 24, 2020 Category: Virology Source Type: research

Chapter Five - Update on immunopathology of bornavirus infections in humans and animals
Publication date: 2020Source: Advances in Virus Research, Volume 107Author(s): Daniel Nobach, Jana Müller, Dennis Tappe, Christiane Herden (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 24, 2020 Category: Virology Source Type: research

Chapter Six - Immunopathology of Zika virus infection
Publication date: 2020Source: Advances in Virus Research, Volume 107Author(s): Derek J. Platt, Jonathan J. Miner (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 24, 2020 Category: Virology Source Type: research

Chapter Seven - One hundred years of (influenza) immunopathology
Publication date: 2020Source: Advances in Virus Research, Volume 107Author(s): David F. Boyd, Taylor L. Wilson, Paul G. Thomas (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 24, 2020 Category: Virology Source Type: research

Chapter Eight - Immunopathology and immune homeostasis during viral infection in insects
Publication date: 2020Source: Advances in Virus Research, Volume 107Author(s): Andrea González-González, Marta L. Wayne (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 24, 2020 Category: Virology Source Type: research

Chapter Nine - Immunopathogenesis of alphaviruses
Publication date: 2020Source: Advances in Virus Research, Volume 107Author(s): Victoria K. Baxter, Mark T. Heise (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 24, 2020 Category: Virology Source Type: research

Chapter Ten - Reverse genetic systems: Rational design of coronavirus live attenuated vaccines with immune sequelae
Publication date: 2020Source: Advances in Virus Research, Volume 107Author(s): Zhiqian Ma, Zhiwei Li, Linfang Dong, Ting Yang, Shuqi Xiao (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 24, 2020 Category: Virology Source Type: research

Immunopathology of Zika virus infection
Publication date: Available online 7 July 2020Source: Advances in Virus ResearchAuthor(s): Derek J. Platt, Jonathan J. Miner (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 9, 2020 Category: Virology Source Type: research

Host protein chaperones, RNA helicases and the ubiquitin network highlight the arms race for resources between tombusviruses and their hosts
Publication date: Available online 7 July 2020Source: Advances in Virus ResearchAuthor(s): Peter D. Nagy (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 9, 2020 Category: Virology Source Type: research

Immunopathogenesis of alphaviruses
Publication date: Available online 8 July 2020Source: Advances in Virus ResearchAuthor(s): Victoria K. Baxter, Mark T. Heise (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 9, 2020 Category: Virology Source Type: research

Immunopathology and immune homeostasis during viral infection in insects
Publication date: Available online 3 July 2020Source: Advances in Virus ResearchAuthor(s): Andrea González-González, Marta L. Wayne (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 4, 2020 Category: Virology Source Type: research

Reverse genetic systems: Rational design of coronavirus live attenuated vaccines with immune sequelae
Publication date: Available online 30 June 2020Source: Advances in Virus ResearchAuthor(s): Zhiqian Ma, Zhiwei Li, Linfang Dong, Ting Yang, Shuqi Xiao (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 1, 2020 Category: Virology Source Type: research

Update on immunopathology of bornavirus infections in humans and animals
Publication date: Available online 30 June 2020Source: Advances in Virus ResearchAuthor(s): Daniel Nobach, Jana Müller, Dennis Tappe, Christiane Herden (Source: Advances in Virus Research)
Source: Advances in Virus Research - July 1, 2020 Category: Virology Source Type: research

One hundred years of (influenza) immunopathology
Publication date: Available online 25 June 2020Source: Advances in Virus ResearchAuthor(s): David F. Boyd, Taylor L. Wilson, Paul G. Thomas (Source: Advances in Virus Research)
Source: Advances in Virus Research - June 26, 2020 Category: Virology Source Type: research

Viral and subviral derived small RNAs as pathogenic determinants in plants and insects
Publication date: Available online 27 May 2020Source: Advances in Virus ResearchAuthor(s): Paola Leonetti, Pascal Miesen, Ronald P. van Rij, Vitantonio Pantaleo (Source: Advances in Virus Research)
Source: Advances in Virus Research - May 29, 2020 Category: Virology Source Type: research

Hijacking of host cellular components as proviral factors by plant-infecting viruses
Publication date: Available online 25 May 2020Source: Advances in Virus ResearchAuthor(s): Kiwamu Hyodo, Tetsuro Okuno (Source: Advances in Virus Research)
Source: Advances in Virus Research - May 26, 2020 Category: Virology Source Type: research

Modulation of disease severity by plant positive-strand RNA viruses: The complex interplay of multifunctional viral proteins, subviral RNAs and virus-associated RNAs with plant signaling pathways and defense responses
Publication date: Available online 21 May 2020Source: Advances in Virus ResearchAuthor(s): Hélène Sanfaçon (Source: Advances in Virus Research)
Source: Advances in Virus Research - May 21, 2020 Category: Virology Source Type: research

Contributors
Publication date: 2020Source: Advances in Virus Research, Volume 106Author(s): (Source: Advances in Virus Research)
Source: Advances in Virus Research - April 22, 2020 Category: Virology Source Type: research

Chapter One - Influenza A virus uncoating
Publication date: 2020Source: Advances in Virus Research, Volume 106Author(s): Yohei Yamauchi (Source: Advances in Virus Research)
Source: Advances in Virus Research - April 22, 2020 Category: Virology Source Type: research

Chapter Two - Structural and cellular biology of adeno-associated virus attachment and entry
Publication date: 2020Source: Advances in Virus Research, Volume 106Author(s): James Zengel, Jan E. Carette (Source: Advances in Virus Research)
Source: Advances in Virus Research - April 22, 2020 Category: Virology Source Type: research

Chapter Three - From foes to friends: Viral infections expand the limits of host phenotypic plasticity
Publication date: 2020Source: Advances in Virus Research, Volume 106Author(s): Rubén González, Anamarija Butković, Santiago F. Elena (Source: Advances in Virus Research)
Source: Advances in Virus Research - April 22, 2020 Category: Virology Source Type: research

Chapter Four - Exploration of the interactions between mycoviruses and Fusarium graminearum
Publication date: 2020Source: Advances in Virus Research, Volume 106Author(s): Jisuk Yu, Kook-Hyung Kim (Source: Advances in Virus Research)
Source: Advances in Virus Research - April 22, 2020 Category: Virology Source Type: research

Chapter Five - Implications of mixed viral infections on plant disease ecology and evolution
Publication date: 2020Source: Advances in Virus Research, Volume 106Author(s): Cristina Alcaide, M. Pilar Rabadán, Manuel G. Moreno-Pérez, Pedro Gómez (Source: Advances in Virus Research)
Source: Advances in Virus Research - April 22, 2020 Category: Virology Source Type: research

Implications of mixed viral infections on plant disease ecology and evolution
Publication date: Available online 13 March 2020Source: Advances in Virus ResearchAuthor(s): Cristina Alcaide, M. Pilar Rabadán, Manuel G. Moreno-Pérez, Pedro Gómez (Source: Advances in Virus Research)
Source: Advances in Virus Research - March 14, 2020 Category: Virology Source Type: research

Influenza A virus uncoating
Publication date: Available online 13 February 2020Source: Advances in Virus ResearchAuthor(s): Yohei YamauchiAbstractInfluenza A virus (IAV) is an enveloped virus of the Orthomyxoviridae with a negative-sense single-stranded RNA genome. During virus cell entry, viral and cellular cues are delivered in a stepwise manner within two distinct cellular compartments—the endosomes and the cytosol. Endosome maturation primes the viral core for uncoating by cytosolic host proteins and host-mediated virus disaggregation is essential for genome import and replication in the nucleus. Recent evidence shows that two well-known ce...
Source: Advances in Virus Research - February 13, 2020 Category: Virology Source Type: research

Structural and cellular biology of adeno-associated virus attachment and entry
Publication date: Available online 13 February 2020Source: Advances in Virus ResearchAuthor(s): James Zengel, Jan E. CaretteAbstractAdeno-associated virus (AAV) is a nonenveloped, ssDNA virus in the parvovirus family, which has become one of the leading candidate vectors for human gene therapy. AAV has been studied extensively to identify host cellular factors involved in infection, as well as to identify capsid variants that confer clinically favorable transduction profiles ex vivo and in vivo. Recent advances in technology have allowed for direct genetic approaches to be used to more comprehensively characterize host fac...
Source: Advances in Virus Research - February 13, 2020 Category: Virology Source Type: research

Exploration of the interactions between mycoviruses and Fusarium graminearum
Publication date: Available online 5 February 2020Source: Advances in Virus ResearchAuthor(s): Jisuk Yu, Kook-Hyung KimAbstractIn this review, we discuss recent studies of the interaction between Fusarium graminearum viruses (FgVs) and the fungal host, Fusarium graminearum. Comprehensive transcriptome and proteome analyses have shown changes in the expression of host genes in response to infection by diverse FgVs. Using omics data and reverse genetics, researchers have determined the effects of some fungal host proteins (including FgHex1, FgHal2, FgSwi6, and vr1) on virus accumulation, virus transmission, and host symptom ...
Source: Advances in Virus Research - February 7, 2020 Category: Virology Source Type: research

From foes to friends: Viral infections expand the limits of host phenotypic plasticity
Publication date: Available online 27 January 2020Source: Advances in Virus ResearchAuthor(s): Rubén González, Anamarija Butković, Santiago F. ElenaAbstractPhenotypic plasticity enables organisms to survive in the face of unpredictable environmental stress. Intimately related to the notion of phenotypic plasticity is the concept of the reaction norm that places phenotypic plasticity in the context of a genotype-specific response to environmental gradients. Whether reaction norms themselves evolve and which factors might affect their shape has been the object of intense debates among evolutionary biologists a...
Source: Advances in Virus Research - January 28, 2020 Category: Virology Source Type: research

Series Page
Publication date: 2019Source: Advances in Virus Research, Volume 105Author(s): (Source: Advances in Virus Research)
Source: Advances in Virus Research - September 13, 2019 Category: Virology Source Type: research

Contributors
Publication date: 2019Source: Advances in Virus Research, Volume 105Author(s): (Source: Advances in Virus Research)
Source: Advances in Virus Research - September 13, 2019 Category: Virology Source Type: research

Preface
Publication date: 2019Source: Advances in Virus Research, Volume 105Author(s): Félix A. Rey (Source: Advances in Virus Research)
Source: Advances in Virus Research - September 13, 2019 Category: Virology Source Type: research

Chapter One - The viral replication organelles within cells studied by electron microscopy
Publication date: 2019Source: Advances in Virus Research, Volume 105Author(s): Martin Sachse, Isabel Fernández de Castro, Raquel Tenorio, Cristina RiscoAbstractTransmission electron microscopy (TEM) has been crucial to study viral infections. As a result of recent advances in light and electron microscopy, we are starting to be aware of the variety of structures that viruses assemble inside cells. Viruses often remodel cellular compartments to build their replication factories. Remarkably, viruses are also able to induce new membranes and new organelles. Here we revise the most relevant imaging technologies to study...
Source: Advances in Virus Research - September 13, 2019 Category: Virology Source Type: research

Chapter Two - Structures of enveloped virions determined by cryogenic electron microscopy and tomography
Publication date: 2019Source: Advances in Virus Research, Volume 105Author(s): Robert Stass, Weng M. Ng, Young Chan Kim, Juha T. HuiskonenAbstractEnveloped viruses enclose their genomes inside a lipid bilayer which is decorated by membrane proteins that mediate virus entry. These viruses display a wide range of sizes, morphologies and symmetries. Spherical viruses are often isometric and their envelope proteins follow icosahedral symmetry. Filamentous and pleomorphic viruses lack such global symmetry but their surface proteins may display locally ordered assemblies. Determining the structures of enveloped viruses, includin...
Source: Advances in Virus Research - September 13, 2019 Category: Virology Source Type: research

Chapter Three - CryoEM reconstruction approaches to resolve asymmetric features
Publication date: 2019Source: Advances in Virus Research, Volume 105Author(s): Daniel J. Goetschius, Hyunwook Lee, Susan HafensteinAbstractAlthough icosahedral viruses have highly symmetrical capsid features, asymmetric structural elements are also present since the genome and minor structural proteins are usually incorporated without adhering to icosahedral symmetry. Besides this inherent asymmetry, interactions with the host during the virus life cycle are also asymmetric. However, until recently it was impossible to resolve high resolution asymmetric features during single-particle cryoEM image processing. This review s...
Source: Advances in Virus Research - September 13, 2019 Category: Virology Source Type: research

Chapter Four - Structural insights into coronavirus entry
Publication date: 2019Source: Advances in Virus Research, Volume 105Author(s): M. Alejandra Tortorici, David VeeslerAbstractCoronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and was responsible for an epidemic that spread to five continents with a fatality rate of 10% before being contained in 2003 (with additional cases reported in 2004). The Middle-East respiratory syndrome coronavirus (MERS-CoV) emerged in the Arabian Peninsula in 2012 and has caused recurrent outbreaks in humans w...
Source: Advances in Virus Research - September 13, 2019 Category: Virology Source Type: research

Chapter Five - Structural analysis of pleomorphic and asymmetric viruses using cryo-electron tomography and subtomogram averaging
Publication date: 2019Source: Advances in Virus Research, Volume 105Author(s): Martin Obr, Florian K.M. SchurAbstractDescribing the protein interactions that form pleomorphic and asymmetric viruses represents a considerable challenge to most structural biology techniques, including X-ray crystallography and single particle cryo-electron microscopy. Obtaining a detailed understanding of these interactions is nevertheless important, considering the number of relevant human pathogens that do not follow strict icosahedral or helical symmetry. Cryo-electron tomography and subtomogram averaging methods provide structural insight...
Source: Advances in Virus Research - September 13, 2019 Category: Virology Source Type: research

Chapter Six - The application of atomic force microscopy for viruses and protein shells: Imaging and spectroscopy
Publication date: 2019Source: Advances in Virus Research, Volume 105Author(s): Pedro J. de PabloAbstractAtomic force microscopy (AFM) probes surface-adsorbed samples at the nanoscale by using a sharp stylus of nanometric size located at the end of a micro-cantilever. This technique can also work in a liquid environment and offers unique possibilities to study individual protein assemblies, such as viruses, under conditions that resemble their natural liquid milieu. Here, I show how AFM can be used to explore the topography of viruses and protein cages, including that of structures lacking a well-defined symmetry. AFM is no...
Source: Advances in Virus Research - September 13, 2019 Category: Virology Source Type: research

Chapter Seven - Structural mass spectrometry goes viral
Publication date: 2019Source: Advances in Virus Research, Volume 105Author(s): Jasmin Dülfer, Alan Kadek, Janine-Denise Kopicki, Boris Krichel, Charlotte UetrechtAbstractOver the last 20 years, mass spectrometry (MS), with its ability to analyze small sample amounts with high speed and sensitivity, has more and more entered the field of structural virology, aiming to investigate the structure and dynamics of viral proteins as close to their native environment as possible. The use of non-perturbing labels in hydrogen-deuterium exchange MS allows for the analysis of interactions between viral proteins and host cell fact...
Source: Advances in Virus Research - September 13, 2019 Category: Virology Source Type: research

Chapter Eight - Illuminating the virus life cycle with single-molecule FRET imaging
Publication date: 2019Source: Advances in Virus Research, Volume 105Author(s): Maolin Lu, Xiaochu Ma, Walther MothesAbstractSingle-molecule Förster resonance energy transfer (smFRET) imaging has emerged as a powerful tool to probe conformational dynamics of viral proteins, identify novel structural intermediates that are hiding in averaging population-based measurements, permit access to the energetics of transitions and as such to the precise molecular mechanisms of viral replication. One strength of smFRET is the capability of characterizing biological molecules in their fully hydrated/native state, which are not ne...
Source: Advances in Virus Research - September 13, 2019 Category: Virology Source Type: research

Chapter Nine - Polyhedra, spindles, phage nucleus and pyramids: Structural biology of viral superstructures
Publication date: 2019Source: Advances in Virus Research, Volume 105Author(s): Fasséli CoulibalyAbstractViral infection causes comprehensive rearrangements of the cell that reflect as much host defense mechanisms as virus-induced structures assembled to facilitate infection. Regardless of their pro- or antiviral role, large intracellular structures are readily detectable by microscopy and often provide a signature characteristic of a specific viral infection. The structural features and localization of these assemblies have thus been commonly used for the diagnostic and classification of viruses since the early days...
Source: Advances in Virus Research - September 13, 2019 Category: Virology Source Type: research

Polyhedra, spindles, phage nucleus and pyramids: Structural biology of viral superstructures
Publication date: Available online 6 September 2019Source: Advances in Virus ResearchAuthor(s): Fasséli CoulibalyAbstractViral infection causes comprehensive rearrangements of the cell that reflect as much host defense mechanisms as virus-induced structures assembled to facilitate infection. Regardless of their pro- or antiviral role, large intracellular structures are readily detectable by microscopy and often provide a signature characteristic of a specific viral infection. The structural features and localization of these assemblies have thus been commonly used for the diagnostic and classification of viruses sin...
Source: Advances in Virus Research - September 7, 2019 Category: Virology Source Type: research

Structural analysis of pleomorphic and asymmetric viruses using cryo-electron tomography and subtomogram averaging
Publication date: Available online 27 August 2019Source: Advances in Virus ResearchAuthor(s): Martin Obr, Florian K.M. SchurAbstractDescribing the protein interactions that form pleomorphic and asymmetric viruses represents a considerable challenge to most structural biology techniques, including X-ray crystallography and single particle cryo-electron microscopy. Obtaining a detailed understanding of these interactions is nevertheless important, considering the number of relevant human pathogens that do not follow strict icosahedral or helical symmetry. Cryo-electron tomography and subtomogram averaging methods provide str...
Source: Advances in Virus Research - August 28, 2019 Category: Virology Source Type: research

Structural mass spectrometry goes viral
Publication date: Available online 27 August 2019Source: Advances in Virus ResearchAuthor(s): Jasmin Dülfer, Alan Kadek, Janine-Denise Kopicki, Boris Krichel, Charlotte UetrechtAbstractOver the last 20 years, mass spectrometry (MS), with its ability to analyze small sample amounts with high speed and sensitivity, has more and more entered the field of structural virology, aiming to investigate the structure and dynamics of viral proteins as close to their native environment as possible. The use of non-perturbing labels in hydrogen-deuterium exchange MS allows for the analysis of interactions between viral proteins and...
Source: Advances in Virus Research - August 28, 2019 Category: Virology Source Type: research

Structural insights into coronavirus entry
Publication date: Available online 22 August 2019Source: Advances in Virus ResearchAuthor(s): M. Alejandra Tortorici, David VeeslerAbstractCoronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and was responsible for an epidemic that spread to five continents with a fatality rate of 10% before being contained in 2003 (with additional cases reported in 2004). The Middle-East respiratory syndrome coronavirus (MERS-CoV) emerged in the Arabian Peninsula in 2012 and has caused recurrent outbre...
Source: Advances in Virus Research - August 23, 2019 Category: Virology Source Type: research

The application of atomic force microscopy for viruses and protein shells: Imaging and spectroscopy
Publication date: Available online 20 August 2019Source: Advances in Virus ResearchAuthor(s): Pedro J. de PabloAbstractAtomic force microscopy (AFM) probes surface-adsorbed samples at the nanoscale by using a sharp stylus of nanometric size located at the end of a micro-cantilever. This technique can also work in a liquid environment and offers unique possibilities to study individual protein assemblies, such as viruses, under conditions that resemble their natural liquid milieu. Here, I show how AFM can be used to explore the topography of viruses and protein cages, including that of structures lacking a well-defined symm...
Source: Advances in Virus Research - August 22, 2019 Category: Virology Source Type: research