Efficient Identification of Inherited Chromosomally Integrated Human Herpesvirus 6 Using Specimen Pooling

Human herpesvirus 6 (HHV-6) species B infects>95% of people during childhood and causes exanthema subitum (roseola) [1]. HHV-6B frequently reactivates in immunocompromised patients and causes significant morbidity [2]. The epidemiology of HHV-6A infection is poorly understood, and this virus does not have clear disease associations. Like other herpesviruses, HHV-6A and HHV-6B establish life-long latency after primary infection. However, they have a unique ability to establish latency by integrating into chromosomal telomeres [3,4].

Source: Journal of Clinical Virology - February 20, 2016 Category: Virology Authors: Joshua A Hill, Ruth Hall-Sedlak, Amalia Magaret, Meei-Li Huang, Danielle M Zerr, Keith R Jerome, Michael Boeckh Source Type: research