Systematic Literature Review on the Incidence of Herpes Zoster in Populations at Increased Risk of Disease in the EU/EEA, Switzerland, and the UK
ConclusionsThe HZ incidence rate in Europe increased with age and varied across high-risk populations, with high rates for solid organ and stem cell transplants, cancer, and rheumatoid arthritis. Most studies were retrospective with methodological differences affecting generalizability and comparability. Future studies should stratify data by IC population, age, sex, severity, medication, and study timeframe. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 24, 2024 Category: Infectious Diseases Source Type: research
Melatonin Attenuates Imiquimod-Induced Psoriasis-Like Inflammation and Restores the Th17/Treg Immune Balance
AbstractPsoriasis is a common immune-mediated skin disease characterized by abnormally reactive inflammation and epidermal hyperplasia. Previous studies have shown melatonin (MLT) has powerful anti-inflammatory effects. The mechanisms that MLT regulates psoriasis-associated skin inflammation remain unclear. Here, in imiquimod-induced psoriasis-like mice, MLT supplementation reduced skin inflammation and corrected the Th17/Treg cell imbalance. Network pharmacology and proteome sequencing analyses revealed that MLT attenuates the inflammatory response in the skin of psoriatic mice by inhibiting the PI3K/Akt signaling pathway...
Source: Inflammation - April 24, 2024 Category: Allergy & Immunology Source Type: research
Blue Notes
Immune-mediated inflammatory disorders (IMIDs) including inflammatory bowel disease (IBD), rheumatoid arthritis (RA), psoriasis/psoriatic arthritis (PSO), and ankylosing spondylitis (AS), are associated with increased risk of major adverse cardiovascular events (MACE). There is uncertainty regarding the cardiovascular safety of newer medications for IMIDs such as biologics and small molecules (anti-IL-23, anti-IL-12/23, anti-TNFs, and JAKi). This network meta-analysis pooled 40 studies (36 RCTs) that reported MACE (myocardial infarction, cerebrovascular accident, unstable angina, cardiovascular death, or heart failure) in ...
Source: Clinical Gastroenterology and Hepatology - April 23, 2024 Category: Gastroenterology Authors: Charles J. Kahi Tags: Blue Notes Source Type: research
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
CONCLUSION: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.PMID:38651202 | DOI:10.12809/hkmj2210364 (Source: Hong Kong Med J)
Source: Hong Kong Med J - April 23, 2024 Category: General Medicine Authors: C S M Wong L L Y Mak V K H Lee R C L Lo M M H Chung F Chu C K Yeung M F Yuen H H L Chan Source Type: research
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
CONCLUSION: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.PMID:38651202 | DOI:10.12809/hkmj2210364 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 23, 2024 Category: General Medicine Authors: C S M Wong L L Y Mak V K H Lee R C L Lo M M H Chung F Chu C K Yeung M F Yuen H H L Chan Source Type: research
Geniposide ameliorates psoriatic skin inflammation by inhibiting the TLR4/MyD88/NF- κB p65 signaling pathway and MMP9
Int Immunopharmacol. 2024 Apr 22;133:112082. doi: 10.1016/j.intimp.2024.112082. Online ahead of print.ABSTRACTPsoriasis is an incurable immune-mediated disease affecting the skin or the joints. There are continuing studies on drugs for psoriasis prevention and treatment. This research found that Geniposide (GE) significantly thinned IMQ mice's skin lesions, reduced the scales, and lowered the presence of inflammatory cells in the pathology in a dose-dependent manner. GE inhibited IL-23, IL-22, IL-17A, IL-12, IL-6, and TNF-α levels in psoriatic mice serum. AKT1, TNF, TLR4, MMP9, MAPK3, and EGFR were selected as the top 6 t...
Source: International Immunopharmacology - April 23, 2024 Category: Allergy & Immunology Authors: Lijuan Liu Huiling Zhang Xinran Tang Mengge Zhang Yayun Wu Ya Zhao Chuanjian Lu Ruizhi Zhao Source Type: research
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
CONCLUSION: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.PMID:38651202 | DOI:10.12809/hkmj2210364 (Source: Hong Kong Med J)
Source: Hong Kong Med J - April 23, 2024 Category: General Medicine Authors: C S M Wong L L Y Mak V K H Lee R C L Lo M M H Chung F Chu C K Yeung M F Yuen H H L Chan Source Type: research
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
CONCLUSION: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.PMID:38651202 | DOI:10.12809/hkmj2210364 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 23, 2024 Category: General Medicine Authors: C S M Wong L L Y Mak V K H Lee R C L Lo M M H Chung F Chu C K Yeung M F Yuen H H L Chan Source Type: research
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
CONCLUSION: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.PMID:38651202 | DOI:10.12809/hkmj2210364 (Source: Hong Kong Med J)
Source: Hong Kong Med J - April 23, 2024 Category: General Medicine Authors: C S M Wong L L Y Mak V K H Lee R C L Lo M M H Chung F Chu C K Yeung M F Yuen H H L Chan Source Type: research
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
CONCLUSION: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.PMID:38651202 | DOI:10.12809/hkmj2210364 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 23, 2024 Category: General Medicine Authors: C S M Wong L L Y Mak V K H Lee R C L Lo M M H Chung F Chu C K Yeung M F Yuen H H L Chan Source Type: research
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
CONCLUSION: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.PMID:38651202 | DOI:10.12809/hkmj2210364 (Source: Hong Kong Med J)
Source: Hong Kong Med J - April 23, 2024 Category: General Medicine Authors: C S M Wong L L Y Mak V K H Lee R C L Lo M M H Chung F Chu C K Yeung M F Yuen H H L Chan Source Type: research
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
CONCLUSION: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.PMID:38651202 | DOI:10.12809/hkmj2210364 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 23, 2024 Category: General Medicine Authors: C S M Wong L L Y Mak V K H Lee R C L Lo M M H Chung F Chu C K Yeung M F Yuen H H L Chan Source Type: research
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
CONCLUSION: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.PMID:38651202 | DOI:10.12809/hkmj2210364 (Source: Hong Kong Med J)
Source: Hong Kong Med J - April 23, 2024 Category: General Medicine Authors: C S M Wong L L Y Mak V K H Lee R C L Lo M M H Chung F Chu C K Yeung M F Yuen H H L Chan Source Type: research
Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology
CONCLUSION: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.PMID:38651202 | DOI:10.12809/hkmj2210364 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 23, 2024 Category: General Medicine Authors: C S M Wong L L Y Mak V K H Lee R C L Lo M M H Chung F Chu C K Yeung M F Yuen H H L Chan Source Type: research
