Otologic Manifestations of Psoriasis: A Systematic Review and Meta-Analysis
Introduction Psoriatic skin lesions are often seen in the auricle and external auditory canal, but middle ear and inner ear manifestations are not easily identified. Several studies have indicated hearing loss and vestibular dysfunction with psoriasis, but the extent of association has not been well defined. Methods A systematic search of PubMed, CINAHL, Scopus, and Cochrane Library was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Included studies described audiometric or vestibular assessment of psoriasis patients. Meta-analysis was represented with odds rat...
Source: Otology and Neurotology - August 1, 2022 Category: ENT & OMF Tags: Review Articles Source Type: research

Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A Systematic Review and Meta-Analysis of 31 Randomized Controlled Trials
ConclusionCurcumin and Curcuma longa Extract had good clinical efficacy in the treatment of Psoriasis, UC and RA, so Curcumin and Curcuma longa Extract could be used in the treatment of the above diseases in the future. The results of Meta-analysis showed that Curcumin and Curcuma longa Extract did not show efficacy in the treatment of oral lichen planus, while Takayasu arteritis, SLE, MS, AS, BD and CD did not report sufficient clinical data for meta-analysis. Therefore, large-sample, multi-center clinical trials are still needed for revision or validation. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - August 1, 2022 Category: Allergy & Immunology Source Type: research

Intense pulsed light treatment for inflammatory skin diseases: a review
AbstractAlthough intense pulsed light (IPL) has been commonly used in the field of medical cosmetics in recent years, the exact outcomes of IPL in the treatment of inflammatory skin diseases remain unclear. To assess the clinical evidence for the use of IPL in the treatment of various inflammatory skin diseases and propose evidence-based recommendations, we searched for relevant publications in the PubMed and Web of Science databases and provided updated information. The inflammatory skin diseases treated with IPL consisted of acne vulgaris, rosacea, psoriasis, hidradenitis suppurativa (HS), atopic dermatitis (AD), Riehl ā...
Source: Lasers in Medical Science - August 1, 2022 Category: Laser Surgery Source Type: research

GSE203029 Abnormal inflammatory traits and downregulated caveolin-1 expression in monocytes of psoriasis patients may relate to psoriatic inflammation and atherosclerosis.
Conclusions: Monocytes from psoriasis patients were more likely to differentiate into M1-dominant macrophages, correlating with inflammatory status and CAV-1 expression. These aberrant inflammatory monocytes not only contribute to psoriatic inflammation by producing psoriatic cytokines, but also have a phenotype that could increase atherosclerosis risk by uptake of oxLDL and formation of foam cells. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - July 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

A Systematic Literature Review of Economic Evaluations and Cost Studies of the Treatment of Psoriasis, Atopic Dermatitis, and Chronic Urticaria
ConclusionsEconomic evaluations for AD and CU may be needed in order to better understand the value of new treatments. Moreover, a clearer delineation for biologic treatments and indirect costs (i.e., productivity losses and gains) may be required. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - July 31, 2022 Category: Dermatology Source Type: research

Comparing willingness-to-pay and time-trade-off as the measures of burden of psoriasis: A pooled analysis of community, hospital, and web-based samples in China
This article aims to report WTP and TTO in Chinese psoriasis patients, and to compare the WTPcure (USD), WTPcontrol (%), and TTO regarding the sensitivity in measuring the burden of psoriasis. Patients were recruited from a community-based cohort, a tertiary hospital, and an online forum. WTP was elicited for two scenarios: WTP for controlling the disease and WTP for curing the disease. WTPcontrol was elicited by asking about the percentage of monthly income that the participant patients would like to pay to fully control the clinical symptoms of psoriasis and WTPcure was elicited as absolute money for curing the disease. ...
Source: Cancer Control - July 30, 2022 Category: Cancer & Oncology Authors: Minxue Shen Hui Xiao Wu Zhu Yan Lu Danrong Jing Yehong Kuang Meng Li Xin Guan Ping Sheng Juan Su Xiang Chen Yi Xiao Source Type: research

Keep an Eye on the Back: Spondyloarthritis in Patients with Acute Anterior Uveitis
ConclusionWe revealed a high prevalence of both, overall and previously undiagnosed, SpA in AAU patients. Therefore, we propose rheumatologic evaluation for all AAU patients with musculoskeletal symptoms. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 29, 2022 Category: Rheumatology Authors: Judith Rademacher, Hanna M Ć¼llner, Torsten Diekhoff, Hildrun Haibel, Sabrina Igel, Dominika Pohlmann, Fabian Proft, Mikhail Protopopov, Valeria Rios Rodriguez, Murat Torgutalp, Uwe Pleyer, Denis Poddubnyy Tags: Full Length Source Type: research

Predicting article citations using data from 100 top-cited publications in the field of Psoriasis Vulgaris and biological agents (PVBA) since 1991: A bibliometric analysis
Conclusions: The breakthrough was made by developing one dashboard to display PVBA100. MeSH terms can be used for predicting article citations in PVBA100. These visualizations of PVBA100 could be applied to future academic pursuits and applications in other academic disciplines. (Source: Medicine)
Source: Medicine - July 29, 2022 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Clinical efficacy and safety of using calcipotriol ā€“betamethasone compounding agent for psoriasis treatment: a systematic review and meta-analysis
AbstractThe main objective is to evaluate clinical efficacy and safety of using calcipotriol ā€“betamethasone compounding agent for psoriasis treatment through a systematic review and meta-analysis. We searched MEDLINE, Embase, The Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biomedical Literature Database (CBM), and WanFang Data from inception till July 31, 2020. Efficacy was evaluated based on primary outcome indicators including skin lesion improvement and overall adverse reaction rate. Secondary outcome indicators included degree of life quality improvement, clinical effectiveness rate, and s...
Source: Archives of Dermatological Research - July 28, 2022 Category: Dermatology Source Type: research

Attitudes and behaviour regarding dose reduction of biologics for psoriasis: a survey among dermatologists worldwide
In conclusion, DR of biologics for psoriasis is part of clinical practice in psoriasis experts globally. Barriers for applying DR included lack of evidence or guidelines, and uncertainty on DR effects and risks. Although growing evidence shows DR feasibility, future studies are needed to accumulate and broaden evidence, along with development of (inter)national guidelines on DR strategies. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - July 28, 2022 Category: Dermatology Source Type: research

Genital Self-Image, Sexual Function, and Quality of Life Among Individuals with Vulvar and Non-Vulvar Inflammatory Dermatoses
Arch Sex Behav. 2022 Jul 28. doi: 10.1007/s10508-022-02353-0. Online ahead of print.ABSTRACTVulvar inflammatory dermatoses (VID; e.g., lichen sclerosus, lichen planus, vulvar dermatitis) can significantly impact sexual function. Both vulvar and non-vulvar inflammatory dermatoses (NVID; i.e., skin conditions not impacting vulvar skin, such as non-genital psoriasis and eczema/dermatitis) have yet to be fully characterized with regard to impact on genital self-image. A 20-min web-based survey was distributed September-November 2020 through social media ads, support groups, and online research recruitment services. Individuals...
Source: Archives of Sexual Behavior - July 28, 2022 Category: Psychiatry & Psychology Authors: Sydney Rivera Anna Flood Chandler Dykstra Debby Herbenick Andrea L DeMaria Source Type: research

From IL-17 to IFN- Ī³ in inflammatory skin disorders: Is transdifferentiation a potential treatment target?
The targeted inhibition of effector cytokines such as interleukin 17 (IL-17) in psoriasis and IL-13 in atopic dermatitis offers impressive efficacy with a favorable side effect profile. In contrast, the downregulation of interferon gamma (IFN-Ī³) in T helper (Th) 1-dominant skin disorders may lead to more adverse events, given the crucial role of IFN-Ī³ in antiviral and antitumoral immunity. Modulating Th17 and Th2 cell differentiation is performed by blocking IL-23 and IL-4, respectively, whereas anti-IL-12 antibodies are only moderately effective in downregulating Th1 lymphocyte differentiation. Therefore, a targeted app...
Source: Frontiers in Immunology - July 28, 2022 Category: Allergy & Immunology Source Type: research

Reassurance Techniques Do Not Significantly Impact Confidence in Biosimilars for Psoriasis: A Survey of a Convenience Sample of Individuals with Self-Identified Psoriasis
ConclusionIdentifying highly impactful methods of improving biosimilar confidence remains a challenge. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - July 28, 2022 Category: Dermatology Source Type: research