Deciphering the causal association and co-disease mechanisms between psoriasis and breast cancer
ConclusionThe results suggest that psoriasis may increase the risk of BC, especially ER- BC, while reverse MR suggests a decreased risk of psoriasis in Her2+ BC. Transcriptome analysis revealed a shared mechanism between psoriasis and BC. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 28, 2024 Category: Allergy & Immunology Source Type: research

Dose reduction of biologics in patients with plaque psoriasis: a review
In conclusion, DR seems promising, but a research gap still exists in randomized, prospective studies testing DR strategies, especially of IL-17/23i, hampering the completion of guidelines on DR. Taking into account the identified barriers and facilitators most likely results in a more successful implementation of biologic DR in practice. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 28, 2024 Category: Drugs & Pharmacology Source Type: research

Efficacy and safety of tildrakizumab for the treatment of moderate-to-severe plaque psoriasis of the scalp: A multicenter, randomized, double-blind, placebo-controlled, Phase 3b study
Scalp psoriasis is common and difficult to treat. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 28, 2024 Category: Dermatology Authors: Kurt Gebauer, Lynda Spelman, Paul S. Yamauchi, Jerry Bagel, Tushar Nishandar, Michael Crane, Iris Kopeloff, Mudgal Kothekar, Siu-Long Yao, Howard L. Sofen Source Type: research

Long-term efficacy, safety, and drug survival of secukinumab in patients with psoriasis in Turkey: a retrospective analysis of real-world experience
CONCLUSIONS: Close monitoring may improve SEC survival in psoriasis patients who require dose escalation and concomitant drugs.PMID:38533357 | PMC:PMC10962371 | DOI:10.5114/ada.2023.135757 (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - March 27, 2024 Category: Dermatology Authors: Fatma Elif Y ıldırım Fatma Asl ı Hapa Source Type: research

Effects of secukinumab combined with tretinoin on metabolism, liver enzymes, and inflammatory factors in patients with moderate to severe psoriasis vulgaris
CONCLUSIONS: Secukinumab combined with tretinoin is more effective in MSP vulgaris, which can visibly reduce inflammatory response without affecting glucose and lipid metabolism and liver function.PMID:38533361 | PMC:PMC10962373 | DOI:10.5114/ada.2023.135605 (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - March 27, 2024 Category: Dermatology Authors: Yong Chen Mei Yi Xiaoyan Pang Mengfei Du Haizhou Chen Zhenshu Li Source Type: research

Does the effectiveness of biological medications in the treatment for psoriasis depend on the moment of starting therapy? A preliminary study
CONCLUSIONS: Our understanding of the effectiveness of the treatments depending on the time of the year combined with the type of biologics used, may further improve results of the therapy.PMID:38533365 | PMC:PMC10962378 | DOI:10.5114/ada.2024.135917 (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - March 27, 2024 Category: Dermatology Authors: Micha ł Niedźwiedź Marcin Noweta Joanna Narbutt Witold Owczarek Magdalena Ci ążyńska Agnieszka Czerwi ńska Janusz Krzy ścin Aleksandra Lesiak Ma łgorzata Skibińska Source Type: research

Aryl hydrocarbon receptor role in chronic inflammatory skin diseases: a narrative review
In conclusion, the AHR is a pivotal player in dermatology, with a multifaceted role in skin physiology and pathology. Understanding the intricacies of AHR signalling in the skin offers promising avenues for the development of novel therapies and preventive strategies for various dermatological conditions. Further research is warranted to elucidate the full scope of AHR's contributions to dermatology and its potential as a therapeutic target.PMID:38533374 | PMC:PMC10962376 | DOI:10.5114/ada.2023.135617 (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - March 27, 2024 Category: Dermatology Authors: Micha ł Dec Hubert Arasiewicz Source Type: research

Treatment of plaque-psoriasis in HIV-positive patients
Acta Dermatovenerol Alp Pannonica Adriat. 2024 Mar;33(1):37-40.ABSTRACTPsoriasis is a chronic inflammatory disease that can often accompany human immunodeficiency virus (HIV) epidemics. Development of psoriasis in HIV patients is correlated with a decrease in CD4+ count. Significant variability in the clinical presentation of psoriasis makes it a challenging disease to diagnose. Furthermore, associated immunodeficiency complicates standard treatment with immunosuppressive and biological therapy. Articles that match the terms psoriasis and HIV were searched in MEDLINE and Embase and selected based on their relevance. Highly...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - March 27, 2024 Category: Dermatology Authors: Vita Jugovac Marija Gulin Dora Bari ć Daniela Ledi ć Drvar Romana Čeović Source Type: research

Exploring the Effect of Xiao-Chai-Hu Decoction on Treating Psoriasis Based on Network Pharmacology and Experiment Validation
CONCLUSION: XCHD showed the therapeutic effect on psoriasis by regulating keratinocyte differentiation, and suppressing inflammation and angiogenesis, which provided a theoretical basis for further experiments and clinical research.PMID:38532341 | DOI:10.2174/0113816128288527240108110844 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Ke He Ziyang Wang Meng Liu Wenqian Du Tingyi Yin Ruimin Bai Qiqi Duan Yuqian Wang Hao Lei Yan Zheng Source Type: research

Effect of smoking cessation on psoriasis vulgaris, palmoplantar pustulosis, and generalized pustular psoriasis
CONCLUSIONS: Compared with continuous smoking, smoking cessation was associated with a decreased risk of developing psoriasis. The risk-reducing effect of smoking cessation was more pronounced in those maintaining a smoke-free status. Smoking cessation and the maintenance of a smoke-free status should be encouraged to prevent the development of psoriasis and all other smoking-related diseases.PMID:38534203 | DOI:10.1093/bjd/ljae130 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 27, 2024 Category: Dermatology Authors: Seong Rae Kim Young-Geun Choi Seong Jin Jo Source Type: research

Cannabidiol exerts multitarget immunomodulatory effects on PBMCs from individuals with psoriasis vulgaris
ConclusionsThese data uncover new potential immunomodulatory properties of this cannabinoid suggesting a possible therapeutic action in the treatment of multiple inflammatory skin diseases. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 27, 2024 Category: Allergy & Immunology Source Type: research

Effectiveness of Ixekizumab in Chinese Patients with Moderate-Severe Plaque Psoriasis with Special Area Involvement: Subanalysis of a Prospective, Multicenter, Observational Real-World Study
ConclusionMost patients had psoriasis involvement in a special body area which was associated with worse QoL. Ixekizumab is similarly effective in reducing disease severity and improving QoL in patients with plaque psoriasis across different special body areas. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - March 27, 2024 Category: Dermatology Source Type: research

Food for thought: A comment on 'Breast-feeding decreases the risk of developing psoriasis through early adulthood'
Br J Dermatol. 2024 Mar 26:ljae135. doi: 10.1093/bjd/ljae135. Online ahead of print.NO ABSTRACTPMID:38529672 | DOI:10.1093/bjd/ljae135 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 26, 2024 Category: Dermatology Authors: Chandler Johnson Wilson Liao Source Type: research

Short-term effectiveness and potential factors of ustekinumab based on real-world data in Chinese psoriasis patients
CONCLUSION: In this study, nearly one-third of patients achieved PASI 75 after only the first-dose ustekinumab treatment. Sex, family history of psoriasis, MS, serum TG level might affect the short-term effectiveness, and serum HDL-C level may be a potential factor. The possibility of achieving treatment goals (PASI 75/90/100) at week 4 increased along with serum HDL-C levels.PMID:38531383 | DOI:10.1080/09546634.2024.2321188 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 26, 2024 Category: Dermatology Authors: Xingyu Li Xiaowen Xie Jiashuai Li Jingjin Hu Kun Hu Minjia Tan Jing Yang Sichun Deng Yijie Liu Mi Zhang Yehong Kuang Junchen Chen Liqiu Liao Wu Zhu Source Type: research

Dual blockade of interleukin-17A and interleukin-17F as a therapeutic strategy for liver fibrosis: Investigating the potential effect and mechanism of brodalumab
Cytokine. 2024 Mar 25;178:156587. doi: 10.1016/j.cyto.2024.156587. Online ahead of print.ABSTRACTLiver fibrosis is a terminal manifestation of various chronic liver diseases. There are no drugs that can reverse the condition. Recently, the importance of interleukin-17 (IL17) in the pathophysiology has been revealed and has attracted attention as a therapeutic target. We aimed to reveal the roles of IL17A and IL17F in liver fibrosis, and to validate the potential of their dual blockade as therapeutic strategy. First, we retrospectively reviewed the longitudinal change of FIB-4 index, a clinical indicator of liver fibrosis, ...
Source: Cytokine - March 26, 2024 Category: Molecular Biology Authors: Kazuki M Matsuda Hirohito Kotani Teruyoshi Hisamoto Ai Kuzumi Takemichi Fukasawa Asako Yoshizaki-Ogawa Shinichi Sato Ayumi Yoshizaki Source Type: research