Homotherapy for heteropathy: Interleukin-41 and its biological functions
Immunology. 2024 Apr 9. doi: 10.1111/imm.13791. Online ahead of print.ABSTRACTInterleukin-41 (IL-41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin-like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti-inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or inflammatory injury. It plays an important role in psoriasis, diabetes, Crohn's disease (CD), osteoarthritis, Kawasaki disease (KD), Grav...
Source: Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Runfeng Shi Meixin He Yongzheng Peng Xu Xia Source Type: research
Homotherapy for heteropathy: Interleukin-41 and its biological functions
Immunology. 2024 Apr 9. doi: 10.1111/imm.13791. Online ahead of print.ABSTRACTInterleukin-41 (IL-41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin-like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti-inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or inflammatory injury. It plays an important role in psoriasis, diabetes, Crohn's disease (CD), osteoarthritis, Kawasaki disease (KD), Grav...
Source: Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Runfeng Shi Meixin He Yongzheng Peng Xu Xia Source Type: research
GSE248626 Double-negative T cells ameliorate psoriasis by selectively inhibition on IL-17A producing γδ T cells
In this study, we aimed to evaluate the protection of DNT cells and explore its underlying mechanism. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Paradoxical Psoriasis
Cytokine blocking therapies have revolutionized the management of psoriasis and atopic dermatitis but can lead to the development of paradoxic psoriasis (PP). Patients treated with biologics should be closely monitored for the development of PP and other paradoxical eruptions (including inflammatory joint disease, inflammatory bowel disease, eczematous eruptions, lupus like eruptions, sarcoidal eruptions, and others) and occasionally the development of cutaneous T-cell lymphoma. Further understanding the immunologic mechanism of these processes will ultimately drive our understanding of and ability to predict and manage PP...
Source: Dermatologic Clinics - April 10, 2024 Category: Dermatology Authors: Mariam Abdelghaffar, Sita Kottilil, Michael J. Murphy, Jeffrey M. Cohen, William Damsky Source Type: research
Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry
CONCLUSION: In the circulation of PsA patients, the TN and CD4+ TCM are characterized with more abundant CD28 and CD127, which effectively distinguished PsA from PsV. This may indicate that individuals undergoing PsV could be stratified at high risk of developing PsA based on the circulating levels of CD28 and CD127 on specific cell subsets.PMID:38590608 | PMC:PMC11001477 | DOI:10.1155/2024/9927964 (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Xudong Sang Tian Gan Gai Ge Dan Li Youming Mei Chun Pan Siyu Long Bibo Xie Xiaobing Yu Zhiming Chen Hongsheng Wang Source Type: research
Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry
CONCLUSION: In the circulation of PsA patients, the TN and CD4+ TCM are characterized with more abundant CD28 and CD127, which effectively distinguished PsA from PsV. This may indicate that individuals undergoing PsV could be stratified at high risk of developing PsA based on the circulating levels of CD28 and CD127 on specific cell subsets.PMID:38590608 | PMC:PMC11001477 | DOI:10.1155/2024/9927964 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - April 9, 2024 Category: Allergy & Immunology Authors: Xudong Sang Tian Gan Gai Ge Dan Li Youming Mei Chun Pan Siyu Long Bibo Xie Xiaobing Yu Zhiming Chen Hongsheng Wang Source Type: research
Role of co ‑inhibitory molecules in the treatment of psoriasis (Review)
Exp Ther Med. 2024 Mar 19;27(5):209. doi: 10.3892/etm.2024.12497. eCollection 2024 May.ABSTRACTPsoriasis is a common chronic inflammatory skin disease characterized by abnormal activation and infiltration of T-cells and excessive proliferation of keratinocytes (KCs). Its pathogenesis is complex and frequently accompanied by the imbalance of T-cell subpopulations, contributing to its development and further exacerbation. Therefore, the immune system, especially T-cells, is mainly involved in the pathogenesis of psoriasis. While T-cell activation not only requires the first recognition of T-cell receptor and major histocompa...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yue Yao Linxi Zeng Xin Huang Jinfang Zhang Guoqiang Zhang Ling Wang Source Type: research
N-Containing triterpenoid saponins from Mussaenda densiflora and identification of heinsiagenin A as a potent immunosuppressant
Bioorg Chem. 2024 Apr 6;147:107351. doi: 10.1016/j.bioorg.2024.107351. Online ahead of print.ABSTRACTEleven triterpenoid saponins, including five new compounds, which were named densiflorasides A - E (1 - 5), were isolated from aerial parts of Mussaenda densiflora (Rubiaceae). Their structures were elucidated based on spectroscopic and single-crystal X-ray diffraction analyses and chemical methods. All the isolated compounds and the aglycone heinsiagenin A were evaluated for their immunosuppressive and antiosteoclastogenic activities in vitro. Compounds 6 - 8 and heinsiagenin A inhibited osteoclastogenesis, with IC50 value...
Source: Bioorganic Chemistry - April 9, 2024 Category: Chemistry Authors: Xiuying Du Dilinaer Litifu Wenlong Yuan Zhongxian Chen Zhenhua Chen Rujun Zhang Jianping Zuo Zemin Lin Weimin Zhao Source Type: research
Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry
CONCLUSION: In the circulation of PsA patients, the TN and CD4+ TCM are characterized with more abundant CD28 and CD127, which effectively distinguished PsA from PsV. This may indicate that individuals undergoing PsV could be stratified at high risk of developing PsA based on the circulating levels of CD28 and CD127 on specific cell subsets.PMID:38590608 | PMC:PMC11001477 | DOI:10.1155/2024/9927964 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - April 9, 2024 Category: Allergy & Immunology Authors: Xudong Sang Tian Gan Gai Ge Dan Li Youming Mei Chun Pan Siyu Long Bibo Xie Xiaobing Yu Zhiming Chen Hongsheng Wang Source Type: research
N-Containing triterpenoid saponins from Mussaenda densiflora and identification of heinsiagenin A as a potent immunosuppressant
Bioorg Chem. 2024 Apr 6;147:107351. doi: 10.1016/j.bioorg.2024.107351. Online ahead of print.ABSTRACTEleven triterpenoid saponins, including five new compounds, which were named densiflorasides A - E (1 - 5), were isolated from aerial parts of Mussaenda densiflora (Rubiaceae). Their structures were elucidated based on spectroscopic and single-crystal X-ray diffraction analyses and chemical methods. All the isolated compounds and the aglycone heinsiagenin A were evaluated for their immunosuppressive and antiosteoclastogenic activities in vitro. Compounds 6 - 8 and heinsiagenin A inhibited osteoclastogenesis, with IC50 value...
Source: Bioorganic Chemistry - April 9, 2024 Category: Chemistry Authors: Xiuying Du Dilinaer Litifu Wenlong Yuan Zhongxian Chen Zhenhua Chen Rujun Zhang Jianping Zuo Zemin Lin Weimin Zhao Source Type: research
Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry
CONCLUSION: In the circulation of PsA patients, the TN and CD4+ TCM are characterized with more abundant CD28 and CD127, which effectively distinguished PsA from PsV. This may indicate that individuals undergoing PsV could be stratified at high risk of developing PsA based on the circulating levels of CD28 and CD127 on specific cell subsets.PMID:38590608 | PMC:PMC11001477 | DOI:10.1155/2024/9927964 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - April 9, 2024 Category: Allergy & Immunology Authors: Xudong Sang Tian Gan Gai Ge Dan Li Youming Mei Chun Pan Siyu Long Bibo Xie Xiaobing Yu Zhiming Chen Hongsheng Wang Source Type: research
Psoriasis and Molecular Target Therapies: Evidence of Efficacy in Preventing Cardiovascular Comorbidities
AbstractPsoriasis is now considered a systemic disease, and several comorbidities have been described such as cardiovascular diseases, neurologic and psychiatric disorders, chronic inflammatory bowel disease, psoriatic arthritis, etc. Regarding cardiovascular comorbidities, major adverse cardiovascular events have been reported in psoriasis patients by multiple epidemiologic studies. Moreover, smoking, obesity, metabolic syndrome, hypertension, dyslipidemia, diabetes and reduced physical activity are associated with psoriasis, increasing cardiovascular risk. Consequently, several aspects should be considered when making th...
Source: Dermatology and Therapy - April 9, 2024 Category: Dermatology Source Type: research
