GSE230842 Celastrol targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression
Contributors : Yang Sun ; Zhu Yuyu ; Jiao Qu ; Zhang ChenyangSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIn the present study, we analyzed single-cell multi-omics data from psoriasis patients and healthy individuals and found that more fibroblast-macrophage communication was present in the dermis of psoriasis lesions, exacerbating psoriasis progression. A natural product library was used to screen for a small molecule compound, celastrol, that could interfere with fibroblast-macrophage communication. It was dem...
Source: GEO: Gene Expression Omnibus - March 31, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Modelling Treatment Sequences in Immunology: Optimizing Patient Outcomes
CONCLUSIONS: Prescribing more efficacious treatments earlier provides a greater opportunity to improve patient outcomes and minimizes treatment failures.PMID:38554238 | DOI:10.1007/s12325-023-02766-w (Source: Adv Data)
Source: Adv Data - March 30, 2024 Category: Epidemiology Authors: Rose J Hart Fareen Hassan Sarah Alulis Karl W Patterson Jennifer Norma Barthelmes Jennifer H Boer Dawn Lee Source Type: research
Real-life management of psoriasis with biological agents during pregnancy
DISCUSSION: The majority of practitioners do not follow recommendations on discontinuation of biologic agents before the planning of pregnancy by patients.PMID:38554588 | DOI:10.1016/j.annder.2024.103254 (Source: Annales de Dermatologie et de Venereologie)
Source: Annales de Dermatologie et de Venereologie - March 30, 2024 Category: Dermatology Authors: C Tran E Mah é M Beylot-Barry D Jullien M-A Richard A-C Fougerousse A Bouznad C Bulai Livideanu A Brun F Amelot F Maccari F Aubin F Benhadou C Paul Source Type: research
Real-life management of psoriasis with biological agents during pregnancy
DISCUSSION: The majority of practitioners do not follow recommendations on discontinuation of biologic agents before the planning of pregnancy by patients.PMID:38554588 | DOI:10.1016/j.annder.2024.103254 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - March 30, 2024 Category: Dermatology Authors: C Tran E Mah é M Beylot-Barry D Jullien M-A Richard A-C Fougerousse A Bouznad C Bulai Livideanu A Brun F Amelot F Maccari F Aubin F Benhadou C Paul Source Type: research
Real-life management of psoriasis with biological agents during pregnancy
DISCUSSION: The majority of practitioners do not follow recommendations on discontinuation of biologic agents before the planning of pregnancy by patients.PMID:38554588 | DOI:10.1016/j.annder.2024.103254 (Source: Annales de Dermatologie et de Venereologie)
Source: Annales de Dermatologie et de Venereologie - March 30, 2024 Category: Dermatology Authors: C Tran E Mah é M Beylot-Barry D Jullien M-A Richard A-C Fougerousse A Bouznad C Bulai Livideanu A Brun F Amelot F Maccari F Aubin F Benhadou C Paul Source Type: research
Modelling Treatment Sequences in Immunology: Optimizing Patient Outcomes
CONCLUSIONS: Prescribing more efficacious treatments earlier provides a greater opportunity to improve patient outcomes and minimizes treatment failures.PMID:38554238 | DOI:10.1007/s12325-023-02766-w (Source: Adv Data)
Source: Adv Data - March 30, 2024 Category: Epidemiology Authors: Rose J Hart Fareen Hassan Sarah Alulis Karl W Patterson Jennifer Norma Barthelmes Jennifer H Boer Dawn Lee Source Type: research
Real-life management of psoriasis with biological agents during pregnancy
DISCUSSION: The majority of practitioners do not follow recommendations on discontinuation of biologic agents before the planning of pregnancy by patients.PMID:38554588 | DOI:10.1016/j.annder.2024.103254 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - March 30, 2024 Category: Dermatology Authors: C Tran E Mah é M Beylot-Barry D Jullien M-A Richard A-C Fougerousse A Bouznad C Bulai Livideanu A Brun F Amelot F Maccari F Aubin F Benhadou C Paul Source Type: research
Real-life management of psoriasis with biological agents during pregnancy
DISCUSSION: The majority of practitioners do not follow recommendations on discontinuation of biologic agents before the planning of pregnancy by patients.PMID:38554588 | DOI:10.1016/j.annder.2024.103254 (Source: Annales de Dermatologie et de Venereologie)
Source: Annales de Dermatologie et de Venereologie - March 30, 2024 Category: Dermatology Authors: C Tran E Mah é M Beylot-Barry D Jullien M-A Richard A-C Fougerousse A Bouznad C Bulai Livideanu A Brun F Amelot F Maccari F Aubin F Benhadou C Paul Source Type: research
Real-life management of psoriasis with biological agents during pregnancy
DISCUSSION: The majority of practitioners do not follow recommendations on discontinuation of biologic agents before the planning of pregnancy by patients.PMID:38554588 | DOI:10.1016/j.annder.2024.103254 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - March 30, 2024 Category: Dermatology Authors: C Tran E Mah é M Beylot-Barry D Jullien M-A Richard A-C Fougerousse A Bouznad C Bulai Livideanu A Brun F Amelot F Maccari F Aubin F Benhadou C Paul Source Type: research
Real-life management of psoriasis with biological agents during pregnancy
DISCUSSION: The majority of practitioners do not follow recommendations on discontinuation of biologic agents before the planning of pregnancy by patients.PMID:38554588 | DOI:10.1016/j.annder.2024.103254 (Source: Annales de Dermatologie et de Venereologie)
Source: Annales de Dermatologie et de Venereologie - March 30, 2024 Category: Dermatology Authors: C Tran E Mah é M Beylot-Barry D Jullien M-A Richard A-C Fougerousse A Bouznad C Bulai Livideanu A Brun F Amelot F Maccari F Aubin F Benhadou C Paul Source Type: research
Real-life management of psoriasis with biological agents during pregnancy
DISCUSSION: The majority of practitioners do not follow recommendations on discontinuation of biologic agents before the planning of pregnancy by patients.PMID:38554588 | DOI:10.1016/j.annder.2024.103254 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - March 30, 2024 Category: Dermatology Authors: C Tran E Mah é M Beylot-Barry D Jullien M-A Richard A-C Fougerousse A Bouznad C Bulai Livideanu A Brun F Amelot F Maccari F Aubin F Benhadou C Paul Source Type: research
Real-life management of psoriasis with biological agents during pregnancy
DISCUSSION: The majority of practitioners do not follow recommendations on discontinuation of biologic agents before the planning of pregnancy by patients.PMID:38554588 | DOI:10.1016/j.annder.2024.103254 (Source: Annales de Dermatologie et de Venereologie)
Source: Annales de Dermatologie et de Venereologie - March 30, 2024 Category: Dermatology Authors: C Tran E Mah é M Beylot-Barry D Jullien M-A Richard A-C Fougerousse A Bouznad C Bulai Livideanu A Brun F Amelot F Maccari F Aubin F Benhadou C Paul Source Type: research
Real-life management of psoriasis with biological agents during pregnancy
DISCUSSION: The majority of practitioners do not follow recommendations on discontinuation of biologic agents before the planning of pregnancy by patients.PMID:38554588 | DOI:10.1016/j.annder.2024.103254 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - March 30, 2024 Category: Dermatology Authors: C Tran E Mah é M Beylot-Barry D Jullien M-A Richard A-C Fougerousse A Bouznad C Bulai Livideanu A Brun F Amelot F Maccari F Aubin F Benhadou C Paul Source Type: research
Real-life management of psoriasis with biological agents during pregnancy
DISCUSSION: The majority of practitioners do not follow recommendations on discontinuation of biologic agents before the planning of pregnancy by patients.PMID:38554588 | DOI:10.1016/j.annder.2024.103254 (Source: Annales de Dermatologie et de Venereologie)
Source: Annales de Dermatologie et de Venereologie - March 30, 2024 Category: Dermatology Authors: C Tran E Mah é M Beylot-Barry D Jullien M-A Richard A-C Fougerousse A Bouznad C Bulai Livideanu A Brun F Amelot F Maccari F Aubin F Benhadou C Paul Source Type: research
Real-life management of psoriasis with biological agents during pregnancy
DISCUSSION: The majority of practitioners do not follow recommendations on discontinuation of biologic agents before the planning of pregnancy by patients.PMID:38554588 | DOI:10.1016/j.annder.2024.103254 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - March 30, 2024 Category: Dermatology Authors: C Tran E Mah é M Beylot-Barry D Jullien M-A Richard A-C Fougerousse A Bouznad C Bulai Livideanu A Brun F Amelot F Maccari F Aubin F Benhadou C Paul Source Type: research
