UPLC/Q-TOF-MS-based metabolomics and molecular docking analysis of Bifidobacterium adolescentis exposure to levofloxacin
Biomed Chromatogr. 2024 Apr 29:e5862. doi: 10.1002/bmc.5862. Online ahead of print.ABSTRACTAntibiotic-associated diarrhea is a common adverse reaction caused by the widespread use of antibiotics. The decrease in probiotics is one of the reasons why antibiotics cause drug-induced diarrhea. However, few studies have addressed the intrinsic mechanism of antibiotics inhibiting probiotics. To investigate the underlying mechanism of levofloxacin against Bifidobacterium adolescentis, we used a metabolomics mass spectrometry-based approach and molecular docking analysis for a levofloxacin-induced B. adolescentis injury model. The ...
Source: Biomedical Chromatography : BMC - April 29, 2024 Category: Biomedical Science Authors: Shisui Feng Yue Guo Qianyi Wang Mingwei Meng Xi Liu Chi Zhang Hua Zheng Hongwei Guo Rigang Lu Danfeng Li Zhiheng Su Hui Song Yonghong Liang Source Type: research
In vitro evaluation of inhibitory effect of Lactobacillus reuteri supernatant on the replication of herpes simplex virus type 1 and expression of UL54, UL52 and UL27 genes
CONCLUSION: The study findings indicated that the supernatant of L. reuteri has a potent anti-HSV-1 effect especially if it is incubated with the virus before inoculation into the cell. Its possible antiviral mechanism is to inhibit the virus by binding to it or changing the surface structure of the virus. Metabolites of L. reuteri can be considered as a novel inhibitor of HSV-1 infection.PMID:38682053 | PMC:PMC11055432 | DOI:10.18502/ijm.v16i1.14877 (Source: Herpes)
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Faezeh Ebneali Mohammad Shayestehpour Ahmad Piroozmand Hossein Sedaghat Shaghayegh Yazdani Zahrasadat Fateminasab Source Type: research
Probiotics: Shaping the gut immunological responses
World J Gastroenterol. 2024 Apr 21;30(15):2096-2108. doi: 10.3748/wjg.v30.i15.2096.ABSTRACTProbiotics are live microorganisms exerting beneficial effects on the host's health when administered in adequate amounts. Among the most popular and adequately studied probiotics are bacteria from the families Lactobacillaceae, Bifidobacteriaceae and yeasts. Most of them have been shown, both in vitro and in vivo studies of intestinal inflammation models, to provide favorable results by means of improving the gut microbiota composition, promoting the wound healing process and shaping the immunological responses. Chronic intestinal c...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Eirini Filidou Leonidas Kandilogiannakis Anne Shrewsbury George Kolios Katerina Kotzampassi Source Type: research
Probiotics: Shaping the gut immunological responses
World J Gastroenterol. 2024 Apr 21;30(15):2096-2108. doi: 10.3748/wjg.v30.i15.2096.ABSTRACTProbiotics are live microorganisms exerting beneficial effects on the host's health when administered in adequate amounts. Among the most popular and adequately studied probiotics are bacteria from the families Lactobacillaceae, Bifidobacteriaceae and yeasts. Most of them have been shown, both in vitro and in vivo studies of intestinal inflammation models, to provide favorable results by means of improving the gut microbiota composition, promoting the wound healing process and shaping the immunological responses. Chronic intestinal c...
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Eirini Filidou Leonidas Kandilogiannakis Anne Shrewsbury George Kolios Katerina Kotzampassi Source Type: research
Effects of Multi-species Synbiotic Supplementation on Circulating miR-27a, miR-33a Levels, and Lipid Parameters in Adult Men with Dyslipidemia; A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
This study aimed to investigate the effects of synbiotic supplementation on circulating miR-27a, miR-33a, and lipid parameters in patients with dyslipidemia. Fifty-six eligible participants were randomly allocated to receive either synbiotic or placebo sachets twice a day for 12 weeks. Each synbiotic sachet contained 3×1010 CFU six species of probiotic microorganisms and 5 grams of inulin and fructooligosaccharide (FOS) as prebiotics. Serum miR-27a and miR-33a expression levels, serum lipids, and apolipoproteins, the fecal concentration of short-chain fatty acids (SCFAs), and Firmicutes and Bacteroidetes phyla were assess...
Source: The British Journal of Nutrition - April 29, 2024 Category: Nutrition Authors: Shekoufeh Salamat Alireza Jahan-Mihan Mohammad Reza Tabandeh Anahita Mansoori Source Type: research
< em > In vitro < /em > evaluation of inhibitory effect of < em > Lactobacillus reuteri < /em > supernatant on the replication of herpes simplex virus type 1 and expression of < em > UL54, UL52 < /em > and < em > UL27 < /em > genes
CONCLUSION: The study findings indicated that the supernatant of L. reuteri has a potent anti-HSV-1 effect especially if it is incubated with the virus before inoculation into the cell. Its possible antiviral mechanism is to inhibit the virus by binding to it or changing the surface structure of the virus. Metabolites of L. reuteri can be considered as a novel inhibitor of HSV-1 infection.PMID:38682053 | PMC:PMC11055432 | DOI:10.18502/ijm.v16i1.14877 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Faezeh Ebneali Mohammad Shayestehpour Ahmad Piroozmand Hossein Sedaghat Shaghayegh Yazdani Zahrasadat Fateminasab Source Type: research
Investigating the therapeutic potential of < em > Bifidobacterium breve < /em > and < em > Lactobacillus rhamnosus < /em > postbiotics through apoptosis induction in colorectal HT-29 cancer cells
CONCLUSION: Our research suggests that postbiotic metabolites may be effective biological products for the prevention and treatment of cancer.PMID:38682058 | PMC:PMC11055435 | DOI:10.18502/ijm.v16i1.14873 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Nafiseh Erfanian Hossein Safarpour Tahmineh Tavakoli Mohammad Ali Mahdiabadi Saeed Nasseri Mohammad Hassan Namaei Source Type: research
Therapeutic effects of probiotics and herbal medications on oxalate nephrolithiasis: a mini systematic review
CONCLUSION: Several strains of probiotics and herbal extracts confer protective effects against kidney stone/nephrolithiasis, indicating their promising nature for being considered as elements of preventive / adjuvant therapeutic strategies.PMID:38682062 | PMC:PMC11055440 | DOI:10.18502/ijm.v16i1.14866 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Hamed Taheri Mohammad Mehdi Feizabadi Reza Keikha Rouhi Afkari Source Type: research
Probiotics: truths and illusions
Iran J Microbiol. 2024 Feb;16(1):1-3. doi: 10.18502/ijm.v16i1.14865.NO ABSTRACTPMID:38682066 | PMC:PMC11055431 | DOI:10.18502/ijm.v16i1.14865 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Sogol Tavanaeian Mohammad Mehdi Feizabadi Source Type: research
UPLC/Q-TOF-MS-based metabolomics and molecular docking analysis of Bifidobacterium adolescentis exposure to levofloxacin
Biomed Chromatogr. 2024 Apr 29:e5862. doi: 10.1002/bmc.5862. Online ahead of print.ABSTRACTAntibiotic-associated diarrhea is a common adverse reaction caused by the widespread use of antibiotics. The decrease in probiotics is one of the reasons why antibiotics cause drug-induced diarrhea. However, few studies have addressed the intrinsic mechanism of antibiotics inhibiting probiotics. To investigate the underlying mechanism of levofloxacin against Bifidobacterium adolescentis, we used a metabolomics mass spectrometry-based approach and molecular docking analysis for a levofloxacin-induced B. adolescentis injury model. The ...
Source: Biomedical Chromatography : BMC - April 29, 2024 Category: Biomedical Science Authors: Shisui Feng Yue Guo Qianyi Wang Mingwei Meng Xi Liu Chi Zhang Hua Zheng Hongwei Guo Rigang Lu Danfeng Li Zhiheng Su Hui Song Yonghong Liang Source Type: research
< em > In vitro < /em > evaluation of inhibitory effect of < em > Lactobacillus reuteri < /em > supernatant on the replication of herpes simplex virus type 1 and expression of < em > UL54, UL52 < /em > and < em > UL27 < /em > genes
CONCLUSION: The study findings indicated that the supernatant of L. reuteri has a potent anti-HSV-1 effect especially if it is incubated with the virus before inoculation into the cell. Its possible antiviral mechanism is to inhibit the virus by binding to it or changing the surface structure of the virus. Metabolites of L. reuteri can be considered as a novel inhibitor of HSV-1 infection.PMID:38682053 | PMC:PMC11055432 | DOI:10.18502/ijm.v16i1.14877 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Faezeh Ebneali Mohammad Shayestehpour Ahmad Piroozmand Hossein Sedaghat Shaghayegh Yazdani Zahrasadat Fateminasab Source Type: research
Investigating the therapeutic potential of < em > Bifidobacterium breve < /em > and < em > Lactobacillus rhamnosus < /em > postbiotics through apoptosis induction in colorectal HT-29 cancer cells
CONCLUSION: Our research suggests that postbiotic metabolites may be effective biological products for the prevention and treatment of cancer.PMID:38682058 | PMC:PMC11055435 | DOI:10.18502/ijm.v16i1.14873 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Nafiseh Erfanian Hossein Safarpour Tahmineh Tavakoli Mohammad Ali Mahdiabadi Saeed Nasseri Mohammad Hassan Namaei Source Type: research
Therapeutic effects of probiotics and herbal medications on oxalate nephrolithiasis: a mini systematic review
CONCLUSION: Several strains of probiotics and herbal extracts confer protective effects against kidney stone/nephrolithiasis, indicating their promising nature for being considered as elements of preventive / adjuvant therapeutic strategies.PMID:38682062 | PMC:PMC11055440 | DOI:10.18502/ijm.v16i1.14866 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Hamed Taheri Mohammad Mehdi Feizabadi Reza Keikha Rouhi Afkari Source Type: research
Probiotics: truths and illusions
Iran J Microbiol. 2024 Feb;16(1):1-3. doi: 10.18502/ijm.v16i1.14865.NO ABSTRACTPMID:38682066 | PMC:PMC11055431 | DOI:10.18502/ijm.v16i1.14865 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Sogol Tavanaeian Mohammad Mehdi Feizabadi Source Type: research
Effects of Multi-species Synbiotic Supplementation on Circulating miR-27a, miR-33a Levels, and Lipid Parameters in Adult Men with Dyslipidemia; A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
This study aimed to investigate the effects of synbiotic supplementation on circulating miR-27a, miR-33a, and lipid parameters in patients with dyslipidemia. Fifty-six eligible participants were randomly allocated to receive either synbiotic or placebo sachets twice a day for 12 weeks. Each synbiotic sachet contained 3×1010 CFU six species of probiotic microorganisms and 5 grams of inulin and fructooligosaccharide (FOS) as prebiotics. Serum miR-27a and miR-33a expression levels, serum lipids, and apolipoproteins, the fecal concentration of short-chain fatty acids (SCFAs), and Firmicutes and Bacteroidetes phyla were assess...
Source: The British Journal of Nutrition - April 29, 2024 Category: Nutrition Authors: Shekoufeh Salamat Alireza Jahan-Mihan Mohammad Reza Tabandeh Anahita Mansoori Source Type: research
