Optimization of Spore Production in Bacillus coagulans Using Response Surface Methodology Approach
This study investigated the spore densities and formation efficiency of B. coagulans. The optimal medium formulation consisted of yeast extract (1.00 g L-1), potassium acetate (20.00 g L-1), and MnSO4 (0.01 g L-1 and 0.03 g L-1). After reaching the optimal medium, a response surface regression equation was established based on the results of central composite design (CCD) experimental designs to optimize time, temperature, and pH parameters. The predicted results thus obtained were in good agreement (R2 = 95.19%) with the results obtained by performing experiments. Multiple regression analysis and analysis of variance (ANO...
Source: Applied Biochemistry and Biotechnology - March 25, 2024 Category: Biochemistry Authors: Seyedeh Habibeh Mirmajidi Cambyz Irajie Amir Savardashtaki Navid Nezafat Mohammad Hossein Morowvat Younes Ghasemi Source Type: research
Photopolymerizable and Antibacterial Hydrogels Loaded with Metabolites from < em > Lacticaseibacillus rhamnosus GG < /em > for Infected Wound Healing
This study provides a facile strategy and insights into the functional design of hydrogels from the perspective of wound microenvironment regulation.PMID:38527924 | DOI:10.1021/acs.biomac.4c00124 (Source: Biomacromolecules)
Source: Biomacromolecules - March 25, 2024 Category: Biochemistry Authors: Yanting Han Zhe Yin Yilin Wang Yuanzhang Jiang Jianming Chen Zhonghua Miao Fang He Ruyue Cheng Lin Tan Ka Li Source Type: research
Investigation of the probiotic supplement ’s effect on obese adults demonstrated a reduction in fasting insulin levels: a double-blind randomized clinical trial
ConclusionThis study may suggest the potential of this combined probiotic supplement for treating obesity and related metabolic disorders. However, further researches are warranted for a definitive determination of its properties. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - March 25, 2024 Category: Endocrinology Source Type: research
Lactobacillus bulgaricus-loaded and chia mucilage-rich gum arabic/pullulan nanofiber film: An effective antibacterial film for the preservation of fresh beef
Int J Biol Macromol. 2024 Mar 21:131000. doi: 10.1016/j.ijbiomac.2024.131000. Online ahead of print.ABSTRACTIn recent years, the development of probiotic film by incorporating probiotics into edible polymers has attracted significant research attention in the field of active packaging. However, the influence of the external environment substantially reduces the vitality of probiotics, limiting their application. Therefore, to improve the probiotic activity, this study devised a novel nanofiber film incorporating chia mucilage protection solution (CPS), gum arabic (GA), pullulan (PUL), and Lactobacillus bulgaricus (LB). SEM...
Source: International Journal of Biological Macromolecules - March 23, 2024 Category: Biochemistry Authors: Xiaowei Huang Liuzi Du Zhihua Li Zhikun Yang Jin Xue Jiyong Shi Shen Tingting Xiaodong Zhai Junjun Zhang Esra Capanoglu Ning Zhang Wei Sun Xiaobo Zou Source Type: research
Diversity, distribution, and bioprospecting potentials of carotenogenic yeast from mangrove ecosystem
This study focuses on 47 red-pigmented yeasts isolated from sediments and plant parts of 13 species of mangrove trees. The relative abundance and distribution of these yeasts varied with plant species and plant parts. The highest number of red yeasts was associated with the mangrove plant Avicennia officinalis (32%). Notably, the leaves harbored the highest percentage (45%) of carotenogenic yeasts, and definite compartmentalization of these yeast species was noticed in mangrove plant parts. All the isolates were molecularly identified and they belonged to the genera of Rhodotorula, Rhodosporidiobolus, and Cryptococcus. The...
Source: Archives of Microbiology - March 23, 2024 Category: Microbiology Authors: K A Nimsi K Manjusha M N Farzana Source Type: research
Lactobacillus bulgaricus-loaded and chia mucilage-rich gum arabic/pullulan nanofiber film: An effective antibacterial film for the preservation of fresh beef
Int J Biol Macromol. 2024 Mar 21:131000. doi: 10.1016/j.ijbiomac.2024.131000. Online ahead of print.ABSTRACTIn recent years, the development of probiotic film by incorporating probiotics into edible polymers has attracted significant research attention in the field of active packaging. However, the influence of the external environment substantially reduces the vitality of probiotics, limiting their application. Therefore, to improve the probiotic activity, this study devised a novel nanofiber film incorporating chia mucilage protection solution (CPS), gum arabic (GA), pullulan (PUL), and Lactobacillus bulgaricus (LB). SEM...
Source: International Journal of Biological Macromolecules - March 23, 2024 Category: Biochemistry Authors: Xiaowei Huang Liuzi Du Zhihua Li Zhikun Yang Jin Xue Jiyong Shi Shen Tingting Xiaodong Zhai Junjun Zhang Esra Capanoglu Ning Zhang Wei Sun Xiaobo Zou Source Type: research
Diversity, distribution, and bioprospecting potentials of carotenogenic yeast from mangrove ecosystem
This study focuses on 47 red-pigmented yeasts isolated from sediments and plant parts of 13 species of mangrove trees. The relative abundance and distribution of these yeasts varied with plant species and plant parts. The highest number of red yeasts was associated with the mangrove plant Avicennia officinalis (32%). Notably, the leaves harbored the highest percentage (45%) of carotenogenic yeasts, and definite compartmentalization of these yeast species was noticed in mangrove plant parts. All the isolates were molecularly identified and they belonged to the genera of Rhodotorula, Rhodosporidiobolus, and Cryptococcus. The...
Source: Archives of Microbiology - March 23, 2024 Category: Microbiology Authors: K A Nimsi K Manjusha M N Farzana Source Type: research
Clostridium butyricum inhibits the inflammation in children with primary nephrotic syndrome by regulating Th17/Tregs balance via gut-kidney axis
This study was d... (Source: BMC Microbiology)
Source: BMC Microbiology - March 23, 2024 Category: Microbiology Authors: Ting Li, Xiaolong Ma, Ting Wang, Wenyan Tian, Jian Liu, Wenke Shen, Yuanyuan Liu, Yiwei Li, Xiaoxu Zhang, Junbai Ma, Xiaoxia Zhang, Jinhai Ma and Hao Wang Tags: Research Source Type: research
Human-derived bacterial strains mitigate colitis via modulating gut microbiota and repairing intestinal barrier function in mice
Unbalanced gut microbiota is considered as a pivotal etiological factor in colitis. Nevertheless, the precise influence of the endogenous gut microbiota composition on the therapeutic efficacy of probiotics in... (Source: BMC Microbiology)
Source: BMC Microbiology - March 23, 2024 Category: Microbiology Authors: Juanjuan Dai, Mingjie Jiang, Xiaoxin Wang, Tao Lang, Leilei Wan and Jingjing Wang Tags: Research Source Type: research
Compensation in Neonatal Clinical Trials: A Perspective
This article examines the challenges in determining the quantum of compensation in neonatal clinical trials using the current formula, which is a corollary to the challenges faced by the authors in procuring clinical trial insurance for the Probiotic supplementation for Prevention of Neonatal Sepsis (ProSPoNS) trial. Further, it suggests a template for a differential formula using birthweight of infants, which is one of the many important factors impacting neonatal mortality.PMID:38517006 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 22, 2024 Category: Pediatrics Authors: Apoorva Mathur Dilip Raja Anju Sinha Subodh S Gupta Y K Gupta Anand S Kawade Ramesh Poluru The ProSPoNS Trial Group Source Type: research
Intranasal administration of Escherichia coli Nissle expressing the spike protein of SARS-CoV-2 induces long-term immunization and prevents spike protein-mediated lung injury in mice
Biomed Pharmacother. 2024 Mar 21;174:116441. doi: 10.1016/j.biopha.2024.116441. Online ahead of print.ABSTRACTWhile current anti-Spike protein (SP) vaccines have been pivotal in managing the pandemic, their limitations in delivery, storage, and the inability to provide mucosal immunization (preventing infections) highlight the ongoing necessity for research and innovation. To tackle these constraints, our research group developed a bacterial-based vaccine using a non-pathogenic E. coli Nissle 1917 (EcN) strain genetically modified to express the SARS-CoV-2 spike protein on its surface (EcN-pAIDA1-SP). We intranasally deliv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 22, 2024 Category: Drugs & Pharmacology Authors: Giovanni Sarnelli Alessandro Del Re Irene Palenca Silvia Basili Franzin Jie Lu Luisa Seguella Aurora Zilli Marcella Pesce Sara Rurgo Giovanni Esposito Walter Sanseverino Giuseppe Esposito Source Type: research
Compensation in Neonatal Clinical Trials: A Perspective
This article examines the challenges in determining the quantum of compensation in neonatal clinical trials using the current formula, which is a corollary to the challenges faced by the authors in procuring clinical trial insurance for the Probiotic supplementation for Prevention of Neonatal Sepsis (ProSPoNS) trial. Further, it suggests a template for a differential formula using birthweight of infants, which is one of the many important factors impacting neonatal mortality.PMID:38517006 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 22, 2024 Category: Pediatrics Authors: Apoorva Mathur Dilip Raja Anju Sinha Subodh S Gupta Y K Gupta Anand S Kawade Ramesh Poluru The ProSPoNS Trial Group Source Type: research
Intranasal administration of Escherichia coli Nissle expressing the spike protein of SARS-CoV-2 induces long-term immunization and prevents spike protein-mediated lung injury in mice
Biomed Pharmacother. 2024 Mar 21;174:116441. doi: 10.1016/j.biopha.2024.116441. Online ahead of print.ABSTRACTWhile current anti-Spike protein (SP) vaccines have been pivotal in managing the pandemic, their limitations in delivery, storage, and the inability to provide mucosal immunization (preventing infections) highlight the ongoing necessity for research and innovation. To tackle these constraints, our research group developed a bacterial-based vaccine using a non-pathogenic E. coli Nissle 1917 (EcN) strain genetically modified to express the SARS-CoV-2 spike protein on its surface (EcN-pAIDA1-SP). We intranasally deliv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 22, 2024 Category: Drugs & Pharmacology Authors: Giovanni Sarnelli Alessandro Del Re Irene Palenca Silvia Basili Franzin Jie Lu Luisa Seguella Aurora Zilli Marcella Pesce Sara Rurgo Giovanni Esposito Walter Sanseverino Giuseppe Esposito Source Type: research
Compensation in Neonatal Clinical Trials: A Perspective
This article examines the challenges in determining the quantum of compensation in neonatal clinical trials using the current formula, which is a corollary to the challenges faced by the authors in procuring clinical trial insurance for the Probiotic supplementation for Prevention of Neonatal Sepsis (ProSPoNS) trial. Further, it suggests a template for a differential formula using birthweight of infants, which is one of the many important factors impacting neonatal mortality.PMID:38517006 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 22, 2024 Category: Pediatrics Authors: Apoorva Mathur Dilip Raja Anju Sinha Subodh S Gupta Y K Gupta Anand S Kawade Ramesh Poluru The ProSPoNS Trial Group Source Type: research
Compensation in Neonatal Clinical Trials: A Perspective
This article examines the challenges in determining the quantum of compensation in neonatal clinical trials using the current formula, which is a corollary to the challenges faced by the authors in procuring clinical trial insurance for the Probiotic supplementation for Prevention of Neonatal Sepsis (ProSPoNS) trial. Further, it suggests a template for a differential formula using birthweight of infants, which is one of the many important factors impacting neonatal mortality.PMID:38517006 (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 22, 2024 Category: Pediatrics Authors: Apoorva Mathur Dilip Raja Anju Sinha Subodh S Gupta Y K Gupta Anand S Kawade Ramesh Poluru The ProSPoNS Trial Group Source Type: research
